Leukocyte-technetium-99m uptake in Crohn’s disease: Does it show subclinical disease?

Mota, Luciene G.; Coelho, Luiz Gonzaga Vaz; Simal, Carlos J. R.; Ferrari, Maria Luisa; Toledo, Clodomiro; Martín-Comín, J.; Diniz, S.A.; Cardoso, Valbert Nascimento

doi:10.3748/wjg.v16.i3.365

Cited by 5 publications

(8 citation statements)

References 17 publications

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“…Some authors aimed to quantify the severity of IBD by means of different parameters, like in-house validated scintigraphic indices (SI) at 99m Tc-HMPAO-WBC scan[13] or the stool radioactivity (defined as the disappearance of 111 In-radiolabelled leukocytes from the spleen[14] or from the whole body retention[14,15], as they migrates toward regions of inflammation). As a matter of fact, such semi-quantitative methods for the assessment of the severity of disease could be important for an objective evaluation of treatment response, although a more extensive demonstration of their usefulness lacks in the literature.…”

Section: Resultsmentioning

confidence: 99%

Role of molecular imaging in the management of patients affected by inflammatory bowel disease: State-of-the-art

Caobelli

Evangelista

Quartuccio

et al. 2016

WJR

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AIMTo present the current state-of-the art of molecular imaging in the management of patients affected by inflammatory bowel disease (IBD).METHODSA systematic review of the literature was performed in order to find important original articles on the role of molecular imaging in the management of patients affected by IBD. The search was updated until February 2016 and limited to articles in English.RESULTSFifty-five original articles were included in this review, highlighting the role of single photon emission tomography and positron emission tomography.CONCLUSIONTo date, molecular imaging represents a useful tool to detect active disease in IBD. However, the available data need to be validated in prospective multicenter studies on larger patient samples.

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Section: Resultsmentioning

confidence: 99%

Role of molecular imaging in the management of patients affected by inflammatory bowel disease: State-of-the-art

Caobelli

Evangelista

Quartuccio

et al. 2016

WJR

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“…In fact, it is well known that the uptake mechanism of HIG is non-specific and it relies on pathophysiological changes occurring at the inflammation site such as the enhanced vascular permeability, blood flow, and transudation of plasma proteins in absence of inflammation leukocyte-mediated [20]. On the other hand, WBCs have been widely used in the study of Crohn's disease both for the evaluation of the extent and inflammatory activity of the disease, and for the study of abscesses and abdominal fistulas that can complicate the disease [21]. In fact, WBC uptake depends on the enhanced influx of granulocytes to the infection/inflammation site mediated via immunological binding to cellular antigens and chemotactic peptides (f-Met-Leu-Phe) [22,23], cytokines (interleukin 1 (IL-1), IL-8, Platelet factor 4 PF-4) [24][25][26], and complement factors (C5a, C5adR) [27].…”

Section: Discussionmentioning

confidence: 99%

The Usefulness of Scintigraphic Studies in the Assessment of Asymptomatic Bowel Disease in Patients with Primary Antibody Diseases

Milito

Cinetto

Megna

et al. 2020

JCM

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Enteropathy may be the first presentation of immunodeficiency or it may occur during the course of the disease and in association with malabsorption in patients affected by primary antibody diseases. For these patients, immunoglobulin G (IgG) replacement therapy prevents infectious and non-infectious complications. Nonetheless some patients cannot achieve optimal IgG trough levels, even when treated with high Ig doses in absence of protein-losing syndromes. We investigated seven patients affected by common variable immunodeficiencies (CVIDs) and treated with high Ig doses (600–800 mg/kg/month) showing low IgG trough level. Patients underwent abdominal scintigraphy with human polyclonal immunoglobulin G labeled with 99mTc and with white blood cells labeled by 111 Indium-oxinate to investigate asymptomatic bowel inflammation. A concentration of labeled leukocytes in abdominal segments greater than that observed with human polyclonal immunoglobulin G was evident only in one patient. In five patients a slight concentration of both radiopharmaceuticals was reported, due to mild intestinal inflammatory response. These data might be related to mild increase of capillary permeability in the absence of inflammation leukocyte mediated. This study discloses a new cause of IgG-accelerated catabolism due to inflammatory bowel conditions without diarrhea in CVID patients.

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“…Patienten chens auf die Therapie und zum Nachweis einer subklinischen entzündlichen Aktivität zu eignen [12,19,26,73]. In der S1-Leitlinie der DGN werden zur Diagnostik entzündlicher Darmerkrankungen primär 99m Tc-markierte Leukozyten empfohlen, ersatzweise 111 In-markierte Leukozyten oder FDG [69].…”

Section: Methodeunclassified

Nuklearmedizinische Entzündungsdiagnostik: Update 2017

Ivančević

2017

Nuklearmediziner

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ZusammenfassungDie Szintigrafie mit radioaktiv markierten Leukozyten und Antigranulozytenantikörpern bildet den Eckpfeiler der nuklearmedizinischen Diagnostik entzündlicher und infektiöser Erkrankungen. Obwohl sich die FDG-PET/CT in der Diagnostik entzündlicher Erkrankungen in immer mehr Indikationen etabliert, bleibt die Szintigrafie mit markierten Leukozyten und Antigranulozytenantikörpern – auch wegen eingeschränkter Verfügbarkeit der FDG – bei entzündlichen Erkrankungen, die mit hoher Wahrscheinlichkeit erregerbedingt sind, die nuklearmedizinische Bildgebung der Wahl. In dieser Übersichtsarbeit werden die Entwicklung und der derzeitige Stellenwert der Leukozyten- und Antigranulozytenantikörperszintigrafie bei den wichtigsten dafür geeigneten Fragestellungen beleuchtet. Abschließend wird auch der aktuelle Kenntnisstand zum Beitrag der Hybridbildgebung SPECT/CT in der Diagnostik entzündlicher Erkrankungen wiedergegeben.

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Leukocyte-technetium-99m uptake in Crohn’s disease: Does it show subclinical disease?

Abstract: The results suggest that 99mTc-HMPAO-labeled leukocyte scintigraphy could be important for determining inflammatory activity in CD even in the absence of clinical symptoms.

Cited by 5 publications

References 17 publications

Role of molecular imaging in the management of patients affected by inflammatory bowel disease: State-of-the-art

Role of molecular imaging in the management of patients affected by inflammatory bowel disease: State-of-the-art

The Usefulness of Scintigraphic Studies in the Assessment of Asymptomatic Bowel Disease in Patients with Primary Antibody Diseases

Nuklearmedizinische Entzündungsdiagnostik: Update 2017

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