Leukocyte migration from a fish eye's view

Deng, Qing; Huttenlocher, Anna

doi:10.1242/jcs.093633

Cited by 47 publications

(36 citation statements)

References 74 publications

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“…Interestingly, neutrophil rTEM following ischemia-reperfusion injury has been associated with dissemination of systemic inflammation (Woodfin et al, 2011), and rTEM could be involved in dissemination of pathogens from a primary site of infection to distant organs (Duffy et al, 2012). Furthermore, based on findings in zebra fish embryos where neutrophils have been seen to migrate away from the site of injury, leukocyte reverse motility has also been proposed as a means of resolving an inflammatory response (Deng and Huttenlocher, 2012).…”

Section: Box 3 a Role For Antigenic Signals In T Cell Diapedesis Andmentioning

confidence: 99%

Leukocyte Migration into Inflamed Tissues

2014

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Leukocyte migration through activated venular walls is a fundamental immune response that is prerequisite to the entry of effector cells such as neutrophils, monocytes, and effector T cells to sites of infection, injury, and stress within the interstitium. Stimulation of leukocytes is instrumental in this process with enhanced temporally controlled leukocyte adhesiveness and shape-changes promoting leukocyte attachment to the inner wall of blood vessels under hydrodynamic forces. This initiates polarized motility of leukocytes within and through venular walls and transient barrier disruption facilitated sequentially by stimulated vascular cells, i.e., endothelial cells and their associated pericytes. Perivascular cells such as macrophages and mast cells that act as tissue inflammatory sentinels can also directly and indirectly regulate the exit of leukocytes from the vascular lumen. In this review, we discuss current knowledge and open questions regarding the mechanisms involved in the interactions of different effector leukocytes with peripheral vessels in extralymphoid organs.

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Section: Box 3 a Role For Antigenic Signals In T Cell Diapedesis Andmentioning

confidence: 99%

Leukocyte Migration into Inflamed Tissues

2014

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“…peripheral blood [26,27]. On the other hand, systemic neutrophil activation preceding the infiltration of cells cannot be ruled out.…”

Section: Mrp-14 In the Peripheral Blood Of Patients With Infection Anmentioning

confidence: 99%

Neutrophil-derived MRP-14 is up-regulated in infectious osteomyelitis and stimulates osteoclast generation

Dapunt

Giese

Maurer

et al. 2015

Journal of Leukocyte Biology

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Bone infections of patients with joint replacement by endoprosthesis (so called “periprosthetic joint infection”) pose a severe problem in the field of orthopedic surgery. The diagnosis is often difficult, and treatment is, in most cases, complicated and prolonged. Patients often require an implant exchange surgery, as the persistent infection and the accompanying inflammation lead to tissue damage with bone degradation and consequently, to a loosening of the implant. To gain insight into the local inflammatory process, expression of the proinflammatory cytokine MRP-14, a major content of neutrophils, and its link to subsequent bone degradation was evaluated. We found MRP-14 prominently expressed in the affected tissue of patients with implant-associated infection, in close association with the chemokine CXCL8 and a dense infiltrate of neutrophils and macrophages. In addition, the number of MRP-14-positive cells correlated with the presence of bone-resorbing osteoclasts. MRP-14 plasma concentrations were significantly higher in patients with implant-associated infection compared with patients with sterile inflammation or healthy individuals, advocating MRP-14 as a novel diagnostic marker. A further biologic activity of MRP-14 was detected: rMRP-14 directly induced the differentiation of monocytes to osteoclasts, thus linking the inflammatory response in implant infections with osteoclast generation, bone degradation, and implant loosening.

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“…In recent years, studies of leukocyte migration in vivo in the zebrafish model, which set a collection of advantages both mammalian and cell lines, have gained widespread attention [5][6][7][8]. The use of in vivo imaging of transgenic zebrafish whose neutrophils express green fluorescence protein (GFP), as well as increased real-time tracking of immune cell migration, provides a new perspective on how chemicals and genetic interference operate on neutrophils' chemotactic response.…”

Section: Introductionmentioning

confidence: 99%

Myeloperoxidase Inactivation Affects Neutrophil Recruitment in Zebrafish Injury-Induced Model

Li¹,

Dl²,

Chen³

et al. 2017

Fish Aquac J

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Uncontrolled migration and excess recruitment of neutrophils can lead to persistent inflammation, tissue damage and disease. Myeloperoxidase is a remarkable target for further understanding the immune cell migration. This study tests the hypothesis that myeloperoxidase may regulate the immune cell activity and provides a new perspective on the treatment of immune diseases by exploring the mechanism of neutrophil migration. Studies of leukocyte migration in vivo in the zebrafish model, which set a collection of advantages both mammalian and cell lines, have gained widespread attention. In this study, we used tg (coro1a: eGFP; lyz: dsred2) and tg (lyz: eGFP) lines labelling both macrophages and neutrophils to study the effect of mpx on neutrophil chemo taxis to wounds. We found that myeloperoxidase was required for neutrophil migration to the wound site in injury-induced inflammation, but not required for neutrophil migration to the infection site in the infection-induced inflammation. Further, the regulation of myeloperoxidase was specific to neutrophil migration to wound inflammation, but was not necessary for macrophage migration. Thus, myeloperoxidase activity shows therapeutic potential for inflammatory disease related to neutrophil migration.

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Leukocyte migration from a fish eye's view

Cited by 47 publications

References 74 publications

Leukocyte Migration into Inflamed Tissues

Leukocyte Migration into Inflamed Tissues

Neutrophil-derived MRP-14 is up-regulated in infectious osteomyelitis and stimulates osteoclast generation

Myeloperoxidase Inactivation Affects Neutrophil Recruitment in Zebrafish Injury-Induced Model

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