Leukocyte Immunoglobulin-Like Receptor (LILR)

Abstract

Historical BackgroundThe leukocyte immunoglobulin (Ig)-like receptor (LILR) multigene family consists of two pseudogenes (LILRP1 and LILRP2) and 11 functional genes that encode five activating (LILRA1, LILRA2, LILRA4, LILRA5, and LILRA6), five inhibitory (LILRB1, LILRB2, LILRB3, LILRB4, and LILRB5), and one soluble (LILRA3) form. The LILR gene family was independently discovered by different investigators around the same time. Immunoglobulin-like transcripts 1 and 2 (ILT1 and ILT2), which correspond to LILRA2 and LILRB1, respectively, were

Genetics and Epigenetics of Atopic Dermatitis: An Updated Systematic Review

“…This may be due to different causes, as because of little knowledge about some genes or because they are not properly curated yet. This might be the cases of CARD14, with similar functions to CARD11 [163]; VSTM1, which behaves as a cytokine [164]; LILRA6, a member of the leukocyte immunoglobulin-like receptor family [165]; mutations in DOCK8 are responsible for an immunodeficiency syndrome [166]; NLRP2 is involved in inflammatory processes [167,168]; RTEL1, a helicase involved in telomere maintenance, has also been found associated to severe dyskeratosis congenita [169]; LT-α (also known as TNF-β), which is a cytokine produced by lymphocytes [170]. Additionally, ADCY10, CUX2, MAST2, MTF1, PANX3, PHLDB1, and SCAND3 have been associated to AD in a single study of exome sequencing [81].…”