“…Reduced bacteriocidal capacity has been reported for a number of organisms, including S. aureus, Escherichia coli, and C. albicans (43,74). In contrast was the report by Kretschmer et al that found the intracellular killing of Streptococcus pyogenes in Down's syndrome neutrophils to be normal, and a wide range of bacteriocidal capacity of these neutrophils toward S. aureus (104). Results of nitroblue tetrazolium reduction testing in neutrophils of Down's syndrome patients has also been mixed, with lower than expected values found by Tan et al and Kretschmer et al and normal values noted by Seger and Barkin (9,104,155,164).…”