Leukocyte function in Down's syndrome quantitative NBT reduction and bactericidal capacity

Systemic disease and periodontitis: manifestations of neutrophil dysfunction

“…Reduced bacteriocidal capacity has been reported for a number of organisms, including S. aureus, Escherichia coli, and C. albicans (43,74). In contrast was the report by Kretschmer et al that found the intracellular killing of Streptococcus pyogenes in Down's syndrome neutrophils to be normal, and a wide range of bacteriocidal capacity of these neutrophils toward S. aureus (104). Results of nitroblue tetrazolium reduction testing in neutrophils of Down's syndrome patients has also been mixed, with lower than expected values found by Tan et al and Kretschmer et al and normal values noted by Seger and Barkin (9,104,155,164).…”

Neutrophil Chemotaxis and Periodontal Status in Down's Syndrome Patients.

“…In DS, susceptibility to infection is increased as a result of both specific and non-specific abnormalities of the immune system [3][4][5][6][7][8]. It has also been demonstrated that in DS patients, the prevalence and severity of advanced periodontal disease are increased [9][10][11][12].…”

Reduced Number of Peripheral Blood Granulocytic Progenitor Cells in Patients with Down's Syndrome

“…With respect to function, several leucocyte enzymes are increased, namely, acid phosphatase, alkaline phosphatase and glucose-6-phosphate dehydrogenase (Mellman et al, 1964;Rosner et all 1964). Neutrophils from patients with Down's syndrome also have a defect in nitrobluetetrazolium reducing capacity and a decrease in the ability to kill staphylococci (Kretschmer et al, 1974).…”