Leukocyte filtration to decrease the number of adherent leukocytes in the cerebral microcirculation after a period of deep hypothermic circulatory arrest

Alaoja, Hanna; Niemelä, Eija; Anttila, Vesa; Dahlbacka, Sebastian; Mäkelä, Jussi; Kiviluoma, Kai; Laurila, Päivi; Kaakinen, Timo; Juvonen, Tatu

doi:10.1016/j.jtcvs.2006.08.041

Cited by 16 publications

(12 citation statements)

References 19 publications

(19 reference statements)

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“…Darling et al [ 13 ] used zero balance ultrafiltration (Z-BUF), a technique that aims to fix the water balance generated by CPB through infusion of saline solution simultaneously to filtration, demonstrating increased arterial partial pressure of oxygen (PaO 2 ), decreased tissue edema and reduced histologic injury. Alaoja et al [ 14 ] studied the filtration of leukocytes, demonstrating reduction in activated leukocytes adhered to tissues.…”

Section: Resultsmentioning

confidence: 99%

Managing the inflammatory response after cardiopulmonary bypass: review of the studies in animal models

Liguori¹,

Kanas²,

Moreira³

2014

Revista Brasileira De Cirurgia Cardiovascular

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ObjectiveTo review studies performed in animal models that evaluated therapeutic interventions to inflammatory response and microcirculatory changes after cardiopulmonary bypass.MethodsIt was used the search strategy ("Cardiopulmonary Bypass" (MeSH)) and ("Microcirculation" (MeSH) or "Inflammation" (MeSH) or "Inflammation Mediators" (MeSH)). Repeated results, human studies, non-English language articles, reviews and studies without control were excluded.ResultsBlood filters, system miniaturization, specific primers regional perfusion, adequate flow and temperature and pharmacological therapies with anticoagulants, vasoactive drugs and anti-inflammatories reduced changes in microcirculation and inflammatory response.ConclusionDemonstrated efficacy in animal models establishes a perspective for evaluating these interventions in clinical practice.

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Section: Resultsmentioning

confidence: 99%

Managing the inflammatory response after cardiopulmonary bypass: review of the studies in animal models

Liguori¹,

Kanas²,

Moreira³

2014

Revista Brasileira De Cirurgia Cardiovascular

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“…With increasing reports on platelet transfusion refractoriness, the necessity of leukocyte filtration has recently attracted considerable attention (McGettrick et al, 2007;Boodram and Evans, 2008;Singh and Kumar, 2009;Miyaji et al, 2010). Clinical evaluation of the performance of the platelet-specific leukocyte filter merely includes leukocyte removal rate, platelet recoveries, and other indicators (Alaoja et al, 2006;Ott et al, 2006). However, few studies consider whether leukocyte filtration disrupts platelet activation.…”

Section: Discussionmentioning

confidence: 99%

Effect of leukocyte filtration on the P-selectin expression of apheresis platelets

Chen

Zhang

et al. 2015

Genet. Mol. Res.

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ABSTRACT. The aim of this study was to investigate the effect of leukocyte filtration on the P-selectin (CD62P) surface expression of apheresis platelets during the retention period. Ten bags of apheresis platelets stored for 1 day (0-24 h) and 10 bags of apheresis platelets stored for 2 days (24-48 h) were used for leukocyte filtration (experimental group). Ten bags of apheresis platelets with the corresponding retention periods but without filtration were used as a negative control (control group). Thereafter, 100 μL of platelet suspensions from apheresis platelets with or without leukocyte filtration were sampled before and after leukocyte filtration for the detection of CD62P surface expression by flow cytometry. No statistical difference in the CD62P (2015) surface expression of apheresis platelets was observed before and after leukocyte filtration (P > 0.05), neither did the CD62P surface expression exhibit any change among the different retention periods. Leukocyte filtration does not affect the CD62P surface expression of apheresis platelets stored for up to 2 days, which indicates that leukocyte filtration does not damage the activation of apheresis platelets within the retention period.

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“…The leukocyte filters used herein were the same as in our previous study to allow for comparison. The filters should be adequate according to [23][24][25]; however, according to Allen/Buckberg [26], the use of a single filter may have been inadequate. It is plausible that the leukocyte filtration could become more efficient, and this should be further evaluated.…”

Section: Limitationsmentioning

confidence: 99%

Mechanical Reperfusion Following Prolonged Global Cerebral Ischemia Attenuates Brain Injury

Lindblom

Tovedal

Norlin

et al. 2020

J. of Cardiovasc. Trans. Res.

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Previous experiments demonstrated improved outcome following prolonged cerebral ischemia given controlled brain reperfusion using extracorporeal circulation. The current study further investigates this. Young adult pigs were exposed to 30 min of global normothermic cerebral ischemia, achieved through intrathoracic clamping of cerebral arteries, followed by 20 min of isolated mechanical brain reperfusion. Leukocyte-filtered blood was delivered by a roller-pump at fixed pressure and flow. One experimental group additionally had a custom-made buffer solution delivered at 1:8 ratio with the blood. Hemodynamics including intracranial pressure were monitored. Blood gases were from peripheral arteries and the sagittal sinus, and intraparenchymal brain microdialysis was performed. The brains were examined by a neuropathologist. The group with the added buffer showed lower intracranial pressure as well as decreased intraparenchymal glycerol and less signs of excitotoxicity and ischemia, although histology revealed similar degrees of injury. A customized mechanical reperfusion improves multiple parameters after prolonged normothermic global cerebral ischemia.

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Leukocyte filtration to decrease the number of adherent leukocytes in the cerebral microcirculation after a period of deep hypothermic circulatory arrest

Abstract: The leukocyte-depleting filter succeeded in reducing the number of adherent leukocytes during the reperfusion period in an experimental operation with deep hypothermic circulatory arrest. Such a filter thus could mitigate cerebral reperfusion injury after cardiac surgery.

Cited by 16 publications

References 19 publications

Managing the inflammatory response after cardiopulmonary bypass: review of the studies in animal models

Managing the inflammatory response after cardiopulmonary bypass: review of the studies in animal models

Effect of leukocyte filtration on the P-selectin expression of apheresis platelets

Mechanical Reperfusion Following Prolonged Global Cerebral Ischemia Attenuates Brain Injury

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