Leukocyte cell population data (volume conductivity scatter) in postprandial leukocyte activation

Klop, Boudewijn; Geijn, Gert Jan M. van de; Njo, Tjin L.; Janssen, Hans W.; Rietveld, A.P.; Miltenburg, Addy van; Fernández-Sender, Laura; Elte, J.W.F.; Cabezas, Manuel Castro

doi:10.1111/ijlh.12103

Cited by 19 publications

(20 citation statements)

References 22 publications

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“…As reported previously, an increase in CR1 expression by monocytes and neutrophils occurs upon the ingestion of a fat meal (35). On average, monocytes and neutrophils express 20,000 to 140,000 CR1 molecules per cell (36,37).…”

Section: Discussionsupporting

confidence: 70%

Differential Complement Activation Pathways Promote C3b Deposition on Native and Acetylated LDL thereby Inducing Lipoprotein Binding to the Complement Receptor 1

Klop

Pol²,

Bruggen

et al. 2014

Journal of Biological Chemistry

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Section: Discussionsupporting

confidence: 70%

Differential Complement Activation Pathways Promote C3b Deposition on Native and Acetylated LDL thereby Inducing Lipoprotein Binding to the Complement Receptor 1

Klop

Pol²,

Bruggen

et al. 2014

Journal of Biological Chemistry

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“…In addition to identifying peripheral leukocyte subsets, automated hematology analyzers also generate data in identifiable patterns that correspond to numerous pathologic conditions. Algorithms that identify patients with bacterial infections , viral infections , malaria , asthma , myocardial infarction , postprandial leukocyte activation , and chronic lymphoproliferative disorders have been described on numerous commercially available hematology analyzers. These algorithms routinely generate data to predict whether patients have the condition in question.…”

Section: Introductionmentioning

confidence: 99%

Automated screening for myelodysplastic syndromes through analysis of complete blood count and cell population data parameters

et al. 2014

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The diagnosis of myelodysplastic syndromes (MDS) requires a high clinical index of suspicion to prompt bone marrow studies as well as subjective assessment of dysplastic morphology. We sought to determine if data collected by automated hematology analyzers during complete blood count (CBC) analysis might help to identify MDS in a routine clinical setting. We collected CBC parameters (including those for research use only and cell population data) and demographic information in a large (>5,000), unselected sequential cohort of outpatients. The cohort was divided into independent training and test groups to develop and validate a random forest classifier that identifies MDS. The classifier effectively identified MDS and had a receiver operating characteristic area under the curve (AUC) of 0.942. Platelet distribution width and the standard deviation of red blood cell distribution width were the most discriminating variables within the classifier. Additionally, a similar classifier was validated with an additional, independent set of >200 patients from a second institution with an AUC of 0.93. This retrospective study demonstrates the feasibility of identifying MDS in an unselected outpatient population using data routinely collected during CBC analysis with a classifier that has been validated using two independent data sets from different institutions.

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“…However, the studies that investigated the effect of glucose on leukocytes' markers of activation have shown conflicting results in T2D [ 45 – 48 ]. On the other hand, postprandial studies reported that leukocytes are activated by lipids [ 38 , 49 , 50 ]. The expression of leukocytes' markers of activation (i.e., CD11b, CD11c) increased on monocytes or neutrophils after a high fat meal [ 50 , 51 ].…”

Section: Discussionmentioning

confidence: 99%

Relationship between the Peroxidation of Leukocytes Index Ratio and the Improvement of Postprandial Metabolic Stress by a Functional Food

Peluso

Manafikhi

Reggi

et al. 2015

Oxidative Medicine and Cellular Longevity

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For the first time, we investigated the relationship between postprandial dysmetabolism and the Peroxidation of Leukocytes Index Ratio (PLIR), a test that measures the resistance of leukocytes to exogenous oxidative stress and their functional capacity of oxidative burst upon activation. Following a blind, placebo controlled, randomized, crossover design, ten healthy subjects ingested, in two different occasions, a high fat and high carbohydrates meal with Snello cookie (HFHCM-S) or with control cookies (HFHCM-C). Snello cookie, a functional food covered by dark chocolate and containing glucomannan, inulin, fructooligosaccharides, and Bacillus coagulans strain GanedenBC30, significantly improved postprandial metabolic stress (insulin, glucose, and triglycerides) and reduced the postprandial increase of uric acid. HFHCM-S improved PLIR of lymphocytes, but not of monocytes and granulocytes. Both meals increased granulocytes' count and reduced the lipoperoxidation induced by both exogenous free radicals and reactive oxygen species (ROS) produced by oxidative burst. Our results suggest that the healthy status of the subjects could be a limitation of this pilot study for PLIR evaluation on cells that produce ROS by oxidative burst. In conclusion, the relationship between PLIR and postprandial dysmetabolism requires further investigations.

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Leukocyte cell population data (volume conductivity scatter) in postprandial leukocyte activation

Abstract: Postprandial leukocyte activation is accompanied by temporary changes in leukocyte cell population data, similar to changes observed during various infections, but to a lesser extent.

Cited by 19 publications

References 22 publications

Differential Complement Activation Pathways Promote C3b Deposition on Native and Acetylated LDL thereby Inducing Lipoprotein Binding to the Complement Receptor 1

Differential Complement Activation Pathways Promote C3b Deposition on Native and Acetylated LDL thereby Inducing Lipoprotein Binding to the Complement Receptor 1

Automated screening for myelodysplastic syndromes through analysis of complete blood count and cell population data parameters

Relationship between the Peroxidation of Leukocytes Index Ratio and the Improvement of Postprandial Metabolic Stress by a Functional Food

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