Leukocyte Adhesion Molecule Expression in Scleritis

Sangwan, Veena; Merchant, Amyna; Maza, Maite Sainz de la; Foster, C. Stephen

doi:10.1001/archopht.116.11.1476

Cited by 15 publications

(7 citation statements)

References 28 publications

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“…The same results were shown by previous studies in the literature (Vorkauf et al 1993;Abu El-Asrar et al 1997;Sangwan et al 1998). Absence of immunoreactivity in controls reflects the absence of all signs of activation or cellular changes, especially in endothelial cells.…”

Section: Discussionsupporting

confidence: 92%

Adhesion molecules (ICAM-1 and VCAM-1) and diabetic retinopathy in type 2 diabetes

2007

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The expression of intercellular adhesion molecule (ICAM-1) and vascular cell adhesion molecule (VCAM-1) were studied in the conjunctiva of diabetic patients with and without retinopathy. All patients underwent a complete ophthalmic examination including ocular fundus and retinal fluorescein angiography. The indirect immunoperoxidase method was performed on 15 normal conjunctivas taken during cataract surgery (group 1), on 40 eyes of 40 patients with type 2 diabetes without diabetic retinopathy (DR) (group 2) and 13 eyes of 13 patients with DR (group 3). ICAM-1 and VCAM-1 are located in epithelial cells, vascular endothelial cells and in stromal cells. Our results show a statistically significant increase in the immunohistochemical expression of these proteins in the conjunctiva of diabetic patients with and without DR in comparison with normal conjunctiva (P = 0.001). Noteworthy, ICAM-1 and VCAM-1 are upregulated in the conjunctiva of diabetic patients with and without retinopathy, reflecting the inflammatory nature of this condition and suggesting a possible role for these mediators in the pathogenesis of diabetic microangiopathy.

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Section: Discussionsupporting

confidence: 92%

Adhesion molecules (ICAM-1 and VCAM-1) and diabetic retinopathy in type 2 diabetes

2007

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“…Inflammatory cell extravasation at sites of inflammation is controlled, at least in part, through the expression of adhesion molecules, such as lymphocyte function associated antigen 1 (LFA‐1) in scleral tissue, and intercellular adhesion molecule 1 (ICAM‐1) and endothelial (E)‐selectin in endothelial cells, which play a major role in this process (Sangwan et al. ). However, the role of circulating cytokines in active scleritis remains unknown.…”

Section: Discussionmentioning

confidence: 99%

“…Immunopathologically, there is a predominance of macrophages, T helper (Th) lymphocytes, and B lymphocytes (Fong et al 1991;Bernauer et al 1994;Usui et al 2008) which may release matrix metalloproteinases causing tissue destruction in necrotizing scleritis (Di Girolamo et al 1997a,b, 1998. Inflammatory cell extravasation at sites of inflammation is controlled, at least in part, through the expression of adhesion molecules, such as lymphocyte function associated * p = 0.012 antigen 1 (LFA-1) in scleral tissue, and intercellular adhesion molecule 1 (ICAM-1) and endothelial (E)-selectin in endothelial cells, which play a major role in this process (Sangwan et al 1998). However, the role of circulating cytokines in active scleritis remains unknown.…”

Section: Discussionmentioning

confidence: 99%

Interleukin‐22 serum levels are elevated in active scleritis

Maza

Molins

Mesquida

et al. 2016

Acta Ophthalmologica

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“…Increased levels of inflammatory adhesion molecules and the presence of cells on the ocular surface are not findings specific to pterygium; these have also been demonstrated in several other ocular conditions such as chronic allergic eye disease, vernal keratoconjunctivitis, scleritis, corneal disease and ocular rosaceous keratoconjunctivitis sicca [35,36,37,38,39,40]. …”

Section: Discussionmentioning

confidence: 99%

Flow Cytometrical Analysis of Adhesion Molecules, T-Lymphocyte Subpopulations and Inflammatory Markers in Pterygium

Tekelioğlu¹,

Türk

Avunduk

et al. 2006

Ophthalmologica

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Background/Aim: Pterygium is a relatively frequent ocular surface disease with an unexplained etiopathogenesis. Our study was carried out with the aim to identify the presence of inflammatory cells and mediators such as T-lymphocyte subgroups (CD4 and CD8), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and human leukocyte antigen-DR (HLA-DR) in pterygium tissue. Methods: Pterygium tissue, obtained from 24 patients, and normal conjunctival tissue, from the nasal bulbar conjunctiva obtained from 14 patients operated for ocular perforations or vitrectomy, were separated into epithelial and stromal components under the microscope and suspended with phosphate-buffered saline solution to form a suspension. Cell suspensions were treated with specific antibodies for ICAM-1, VCAM-1, and HLA-DR and T-lymphocyte subgroups and evaluated with flow cytometry. The obtained data were compared statistically. Results: When compared to the control tissue samples, higher rates of ICAM-1-positive cells, VCAM-1-positive cells and HLA-DR-positive cells were recorded in pterygium tissue samples. CD4 and CD8 lymphocytes were also found to be at higher levels when compared to the control group. There was a statistically significant difference between the two groups. Conclusion: When compared with normal conjunctival tissue, pterygium tissue had increased levels of T-lymphocyte infiltration and inflammatory markers demonstrating the possible contribution of cellular immunity to the pathogenesis.

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Leukocyte Adhesion Molecule Expression in Scleritis

Cited by 15 publications

References 28 publications

Adhesion molecules (ICAM-1 and VCAM-1) and diabetic retinopathy in type 2 diabetes

Adhesion molecules (ICAM-1 and VCAM-1) and diabetic retinopathy in type 2 diabetes

Interleukin‐22 serum levels are elevated in active scleritis

Flow Cytometrical Analysis of Adhesion Molecules, T-Lymphocyte Subpopulations and Inflammatory Markers in Pterygium

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