Leuko-Araiosis on Magnetic Resonance Imaging and Speed of Mental Processing

Junqué, Carme; Pujol, Jesús; Vendrell, Pere; Bruna, Olga; Jódar, Mercé; Ribas, Joan; Viñas, Jaume; Capdevila, Antoni; Martí-Vilalta, J L

doi:10.1001/archneur.1990.00530020047013

Cited by 254 publications

(143 citation statements)

References 34 publications

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“…40 In patients with multiple infarcts or with subcortical arteriosclerotic encephalopathy the accompanying dilatation of the ventricular system is thought to be secondary to the white matter changes resulting from ischemia. 15 -' 8 However, this does not explain why several studies found, as we did, that the relation between ventricular enlargement and cognitive function, or subsequent development of dementia, was independent of the effect of white matter lesions and infarcts. 161719 Our results suggest that the two measures to some extent reflect different underlying processes.…”

contrasting

confidence: 68%

“…Most previous studies that investigated nondemented subjects did not show a clear relation between white matter lesions on MRI and cognitive function. However, small sample sizes 6 -9 -10 or restricted sampling of the population (including only subjects with cerebrovascular events 8 or, conversely, excluding subjects with vascular risk factors, 9 or selecting volunteers on the basis of good performance 7 ) may have resulted in too little power to detect existing differences.…”

Section: Discussionmentioning

confidence: 99%

“…Most previous studies that investigated whether these lesions are related to cognitive impairment suffered from methodological drawbacks that limited the interpretation of their results; eg, they mainly included demented patients, 67 were based on highly selective samples of volunteers, 8 ' 11 or had very small sample sizes. 8 - 10 It is of major importance to know whether these lesions truly reflect the early stages of vascular dementia because potential measures of intervention are available. 12 -13 Another frequent finding in elderly persons that also has been related to cognitive decline is an increase in ventricular volume.…”

mentioning

confidence: 99%

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Cognitive correlates of ventricular enlargement and cerebral white matter lesions on magnetic resonance imaging. The Rotterdam Study.

Breteler¹,

Amerongen²,

Swieten³

et al. 1994

Stroke

319

200

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Background and Purpose Ventricular enlargement and white matter lesions are frequent findings on cerebral magnetic resonance imaging scans of elderly subjects. In demented subjects they seem related to the severity of the dementia, but in nondemented subjects their clinical significance is less clear. We investigated the relation of size of the lateral ventricles and white matter lesions with cognitive function in a population-based random sample of nondemented elderly persons.Methods The study population consisted of 90 subjects, aged 65 to 84 years, who were randomly selected from the cohort of the Rotterdam Study, and who were not demented. The presence of white matter lesions and the ventricle-tobrain ratio were assessed on magnetic resonance scans. Participants were tested with a neuropsychological battery that covered a broad range of cognitive functions.Results Ventricular enlargement and white matter lesions were both and independently associated with poorer performance on all tests. After adjustment for age and sex, ventric-

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contrasting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Cognitive correlates of ventricular enlargement and cerebral white matter lesions on magnetic resonance imaging. The Rotterdam Study.

Breteler¹,

Amerongen²,

Swieten³

et al. 1994

Stroke

319

200

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“…1 Such white matter changes are seen as white matter hyperintensities (WMH) on T2-weighted MRI, and are frequently associated with poorer performance on tests of cognitive and motor skills in numerous cross-sectional studies. [2][3][4][5] The natural history of WMH change and its contribution to CNS decline in cognitively intact elderly is unclear. While some have reported differing etiologies of periventricular (PV) WMH from subcortical WMH, 6,7 there is evidence from others 8 that a clear distinction between the two is not warranted.…”

mentioning

confidence: 99%

Impact of white matter hyperintensity volume progression on rate of cognitive and motor decline

Silbert¹,

Nelson²,

Howieson³

et al. 2008

Neurology

225

216

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“…[59][60][61][62][63][64] Evidence of WMHs within brain pathways known to support mobility, cognition, or voiding confirms this association. 63,64 Details seen on MRI of the brain have allowed localization and quantification of the disseminated WMHs.…”

Section: 58mentioning

confidence: 78%

Small Vessel Disease of the Brain and Stroke: Association with Clinic and Ambulatory Blood Pressure

Gupta¹,

White²,

Ram³

2016

Hypertension Journal

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Several potential vascular risk factors exist for the development and accumulation of small vessel disease of the brain and stroke in older people. In older people followed up for several years, we and others have reported that white matter hyperintensity lesions on magnetic resonance imaging nearly doubled in volume and were associated with alterations in neurologic function. In this article, we review blood pressure (BP) as a risk factor for the development and pathogenesis of small vessel disease and stroke in older persons. The research efforts have focused on ambulatory BP measurements, which have proven to be a stronger indicator than clinic pressures for the progression of small vessel disease in older people as well as the development of stroke. Based on relations among 24 hours systolic BP levels, the accrual of small vessel disease, and relations with cognitive function and mobility, we have designed the INFINITY trial, a novel interventional study that uses ambulatory BP to guide antihypertensive therapy addressed at improving functional decline.

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Leuko-Araiosis on Magnetic Resonance Imaging and Speed of Mental Processing

Cited by 254 publications

References 34 publications

Cognitive correlates of ventricular enlargement and cerebral white matter lesions on magnetic resonance imaging. The Rotterdam Study.

Cognitive correlates of ventricular enlargement and cerebral white matter lesions on magnetic resonance imaging. The Rotterdam Study.

Impact of white matter hyperintensity volume progression on rate of cognitive and motor decline

Small Vessel Disease of the Brain and Stroke: Association with Clinic and Ambulatory Blood Pressure

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