Leukemogenic Activity of Filtrates from Radiation-Induced Lymphoid Tumors of Mice

Lieberman, Miriam; Kaplan, Henry S.

doi:10.1126/science.130.3372.387

Cited by 344 publications

(132 citation statements)

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“…The successful isolation of a filterable MIuLV' from chemically iinduiced lvympho- mata (Haren-Ghera, 1967;Toth, 1963;Irino, Ota and Sezaki, 1963;Ball and McCarter, 1971) and radiation induced lymphomata (Leiberman and Kaplan, 1959;Kaplan, 1967;Latarjet and Duplan, 1962) has been reported before. MuLV from oestrogen induced lymphomata has been successfully isolated for the first time by Kunii, Takemoto and Furth (1965 (Lilly, 1970;McDevitt and Bodmer, 1972).…”

Section: D1iscrssionmentioning

confidence: 76%

Activation of murine leukaemia virus under different physiological conditions

Karande¹,

Taskar²,

Ranadive³

1975

Br J Cancer

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Summary.-The leukaemic lesions in intact and ovariectomized mice of strain ICRC, induced with 20-methylcholanthrene (20-MCA) in combination with or without hormones were investigated for the presence of mouse leukaemia virus (MuLV) by (i) bioassays and (ii) electron microscopy. The different experimental groups treated with 20-MCA were (i) intact females, (ii) ovariectomized females, (iii) ovariectomized females with pituitary graft, (iv) ovariectomized females with 10 jg oestradiol/day for 30 days and (v) ovariectomized females with 1 ,g oestradiol together with 1 mg progesterone/day for 30 days. It was possible to trahismit nearly all these experimentally induced leukaemias to syngeneic mice thtough acellular extracts, compared with very poor transmissibility of spontaneous leukaemias in the ICRC strain, indicating functional activation of viral agents on combined treatment with carcinogen and hormones. Potency of the acellular leukaemic extract from the mice of group (ii) without the ovarian hormones was much weaker than that from mice of the other experimental groups. The leukaemogenic activity of MuLV was enhanced on serial transmission in syngeneic hosts. Leukaemic lesions of ovariectomized mice treated with 20-MCA and oestradiol were also transmissible to the sucklings of allogeneic mice of strain C3H-MTV, C57-BL and Dba-MTV. The cell-free supernatant medium of the cultures of these leukaemic lesions induced leukaemias on back inoculation into syngeneic mice. Electron microscopic studies of lesions induced with carcinogen and oestradiol consistently showed abundant intracytoplasmic type A particles. Numerous intracytoplasmic type A particles as well as some type B particles were found in the leukaemic tissues of ovariectomized females treated with MCA and oestradiol combined with progesterone. Type C particles, characteristic of MuLV were seen in the leukaemic tissues of all other experimental groups. These findings indicate a significant influence of the physiological condition of the host, particularly the hormonal make up, on expression and activity of specific viral agents.

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Section: D1iscrssionmentioning

confidence: 76%

Activation of murine leukaemia virus under different physiological conditions

Karande¹,

Taskar²,

Ranadive³

1975

Br J Cancer

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“…C57BL/Ka is a substrain of strain C57BL (H-2 b) maintained by Dr. Henry S. Kaplan at Stanford University. This substrain is characterized by 90-100% lymphoma incidence after whole body irradiation (9,10). Briefly, thymus, spleen, and lymph nodes were removed, pooled, homogenized in phosphate-buffered saline (PBS) to make a 20% suspension (vol/vol), and centrifuged at 10,000 rpm for 15 rain.…”

Section: Methodsmentioning

confidence: 99%

“…RadLV preparations were cell-free extracts obtained from virus-induced lymphoid tumors of C57BL/Ka mice as previously described (9,10). C57BL/Ka is a substrain of strain C57BL (H-2 b) maintained by Dr. Henry S. Kaplan at Stanford University.…”

Section: Methodsmentioning

confidence: 99%

Genetic control of radiation leukemia virus-induced tumorigenesis. I. Role of the major murine histocompatibility complex, H-2.

Meruelo¹,

Leiberman²,

Ginzton³

et al. 1977

The Journal of Experimental Medicine

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Resistance to radiation leukemia virus-induced leukemogenesis is associated with the H-2D region of the H-2 complex, or with closely linked loci. The H-2Dd allele confers resistance ot the disease, while the H-2D-Q and H-2Ds alleles are associated with susceptibility. It is not clear whether Ir genes, or an alternative mechanism are responsible for the observed H-2-linked resistance to the disease.

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“….. -A f i 1 terabl e and transmissible virus is01 ated from radiation induced leukemia i n mice has been passed s e r i a l l y by c e l l -free f i l t r a t e s (89,52). This viral ,agent induces leukemia in susceptible non i r r a d i a t e d mice and r a t s .…”

Section: Granulocytic Leukemia -This S I T U a T I O N I S Similar mentioning

confidence: 99%

Detection of virus-like particles from radiation-induced leukemia in swine.

Frazier¹

1972

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commission DISCLAIMER This report was prepared as an account of work sponsored by an agency of the United States Government. Neither the United States Government nor any agency Thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise does not necessarily constitute or imply its endorsement, recommendation, or favoring by the United States Government or any agency thereof. The views and opinions of authors expressed herein do not necessarily state or reflect those of the United States Government or any agency thereof. DISCLAIMERPortions of this document may be illegible in electronic image products. Images are produced from the best available original document. Marvin E. F r a z i e r M.S .; U n i v e r s i t y ' of Oregon Medical School , 1967 Presented i n p a r t i a l f u l f i l l m e n t o f t h e requirements f o r t h e degree o f Flow Chart f o r t h e I s o l a t i o n o f Viruses t h a t CauseCytopathic E f f e c t s i n C e l l C u l t u r e . . . . . . . . . In a 12-year study, Holzworth stated t h a t 19% of cats necropsied were affected by neoplasms of the blood forming organs (58,59). . The transmission of f e l i n e leukemia by cell-free f i l t r a t e s (72) has given a fresh impetus t o the study of virus i nduced 1 eu kemi as. Radiation from certain deposited internal emitters also appears t o be a potent lelrke~nugenic factor. I t i s well known t h a t bone seeking radi onucl i des are particularly effective in The preval ence of 1 eu kemi a in various experimental groups ranged from a low of 4% in control animals t o .nearly 80% i n animals exposed t o ' O S~ --i n utero and l a t e r t o 1.25 pCi of ' Osr per day throughout' thei r l i fetime (Table 1.1 ) .Possibly the single most i n t e r e s t i n g r e s u l t of the B a t t e l l e studies was the d i v e r s i t y of the hemopoietic disorders encountered. I.Aging mini-swine have an undetermined incidence of spontaneous -- F1 SF2* Removed from gOSr' feeding a t 3 months o f age.t Fed 90Sr 31 months. Held u n t i l 105 t o 108 months o f age.. . . I t could be argued t h a t swine leukemia i s not a spontaneous disease, b u t one caused by highly a r t i f i c i a l conditions . Analysis I of the information available from radiation-induced leukemia of mice and man, however, suggests t h a t t h i s system i s not a laboratory a r t i f a c t . For example i t has been reported t h a t the type of leukemia produced in mice or humans by irradiation i s similar t o the naturally occurring disease of each species (95). The only differences a r e an increased overall incidence of disease due t o the action of the radiation or a decreased incubation period before th...

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Leukemogenic Activity of Filtrates from Radiation-Induced Lymphoid Tumors of Mice

Cited by 344 publications

References 4 publications

Activation of murine leukaemia virus under different physiological conditions

Activation of murine leukaemia virus under different physiological conditions

Genetic control of radiation leukemia virus-induced tumorigenesis. I. Role of the major murine histocompatibility complex, H-2.

Detection of virus-like particles from radiation-induced leukemia in swine.

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