Leukemic Reticulosis and Allied Disorders

Fukuda, Takao

doi:10.1620/tjem.87.1

Tohoku J. Exp. Med.

1965

DOI: 10.1620/tjem.87.1

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Leukemic Reticulosis and Allied Disorders

Takao Fukuda

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1968

1979

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Cited by 8 publications

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Malignant histiocytosis: A case of generalized histiocytosis with infiltration of Langerhans' granule-containing histiocytes

Imamura

Sakamoto

Hanazono

1971

Cancer

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A 9‐year‐old girl with leukemic infiltration of cells characterized by indented nuclei and abundant faintly acidophilic cytoplasm was autopsied. Electron microscopic studies of the cervical lymph nodes and tumor nodules in the liver and kidney (fixed in formalin solution for 3 years) together with the specimens taken from the cutaneous eruptions at autopsy demonstrated that the proliferating cells frequently contained Langerhans' granules in the cytoplasm. Accordingly, this case was thought to be a disease with systemic, progressive, and malignant proliferation of Langerhans' granule‐containing histiocytes (LGH). The intimate relationship between Letterer‐Siwe's disease and LGH has recently been recognized. Inasmuch as the present case satisfied both the clinicopathologic criteria of Letterer‐Siwe's disease and malignant histiocytosis, the proliferating histiocytes in both of them could be the same type of cell (LGH).

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Malignant histiocytosis: A case of generalized histiocytosis with infiltration of Langerhans' granule-containing histiocytes

Imamura

Sakamoto

Hanazono

1971

Cancer

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Neoplastic reticulosis associated with chronic myelogenous leukemia

Fukuda

1968

Virchows Arch. Abt. A Path. Anat.

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Histiocytic Medullary Reticulosis

Toyoda

Kawaguchi

Akai

1979

Acta Pathologica Japonica

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An autopsy case of histiocytic medullary reticulosis (HMR) in a 55‐year‐old man is presented. The initial complaint of the patient was an unusual skin lesion on the right upper arm, and subsequently developed generalized erythematous skin lesions which regressed during the course of the illness. The clinical symptoms and course of the disease were those of HMR. The affected organs were lymph nodes, spleen, liver and bone marrow as well as the skin, in which erythrophagocytic histiocytes predominated in abnormal cells of the histiocytic series. Phagocytic histiocytes had large amounts of cholesterol and small amounts of phospholipids which might be originated from the ingested erythrocytes. The electron microscopy suggested the presence of phospholipid‐cholesterol interaction in the phagocytic histiocytes.

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Leukemic Reticulosis and Allied Disorders

Cited by 8 publications

References 8 publications

Malignant histiocytosis: A case of generalized histiocytosis with infiltration of Langerhans' granule-containing histiocytes

Malignant histiocytosis: A case of generalized histiocytosis with infiltration of Langerhans' granule-containing histiocytes

Neoplastic reticulosis associated with chronic myelogenous leukemia

Histiocytic Medullary Reticulosis

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