Leukemic Corneal Infiltrates

Eiferman, Richard A.; Levartovsky, Shumel; Schulz, John C.

doi:10.1016/0002-9394(88)90019-0

Cited by 6 publications

(3 citation statements)

References 2 publications

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“…Occasionally there can be ring-shaped corneal ulcers, subepithelial limbal infiltrates and peripheral ulcers. (Taylor, 1997;Rosenthal, 1983;Eiferman et al, 1988).…”

Section: Corneamentioning

confidence: 99%

Ophthalmological Manifestations in Acute Lymphoblastic Leukemia

Mateo¹,

Ascaso²,

Núñez³

et al. 2011

Novel Aspects in Acute Lymphoblastic Leukemia

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“…Occasionally there can be ring-shaped corneal ulcers, subepithelial limbal infiltrates and peripheral ulcers. (Taylor, 1997;Rosenthal, 1983;Eiferman et al, 1988).…”

Section: Corneamentioning

confidence: 99%

Ophthalmological Manifestations in Acute Lymphoblastic Leukemia

Mateo¹,

Ascaso²,

Núñez³

et al. 2011

Novel Aspects in Acute Lymphoblastic Leukemia

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“…Diffuse or focal corneal immunoprotein deposits are a relatively uncommon manifestation of several systemic illnesses, including multiple myeloma, 1 monoclonal gammopathy of unknown significance, 2 Waldenstrom macroglobulinemia, 3 certain lymphoproliferative disorders, 4 and leukemia. 5 The deposits can be initial or early manifestations of these systemic illnesses. 1,[3][4][5] Deposits generally develop gradually 1-5 and involve both eyes.…”

Section: Commentmentioning

confidence: 99%

“…5 The deposits can be initial or early manifestations of these systemic illnesses. 1,[3][4][5] Deposits generally develop gradually 1-5 and involve both eyes. [1][2][3][4] Although some patients experience no reduction in visual acuity, many require treatment of the underlying disease with cytotoxic chemotherapy or corticosteroids to restore visual function, and penetrating keratoplasty may be required in severe cases.…”

Section: Commentmentioning

confidence: 99%

Acute Unilateral Corneal Immunoprotein Deposition in IgM Monoclonal Gammopathy

Schelonka¹,

Ogawa²,

O’Brien

et al. 2000

Arch Ophthalmol

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A healthy 43-year-old officer of a merchant ship at sea developed pain, redness, and photophobia in his right eye. During the next 2 weeks, he noted the presence of a band of opacity spreading from his temporal limbus toward his central cornea. His episcleral vessels were engorged in a distribution contiguous with the peripheral, sectorial, flecklike corneal opacities. The opacity had progressed during topical and systemic antibiotic therapy, but halted with use of topical corticosteroids. Systemic evaluation showed mild IgM monoclonal gammopathy. Transmission electron microscopy of a corneal biopsy specimen revealed electrondense fibrils identified as immunoprotein. To our knowledge, this is the first report of a case of acute unilateral deposition of corneal immunoprotein in a patient with monoclonal gammopathy. Clinicians should begin with a broad differential diagnosis when evaluating patients with corneal opacity.

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