Leukemia with malaria: An unusual presentation

Thapliyal, Naveen; Rawat, Vikram Singh; Singh, Suvir; Jha, RS

doi:10.4103/0019-509x.82889

Cited by 2 publications

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“…Currently, the coumarinic reasons are used in the field of biotechnologies (fluorescent probes) [6] and likely to have very varied biological effects. The molecule 7-hydroxy-4-methylcoumarine is thus used like ligand fluorescent [7] and starting product for the insecticidal preparation of derivative of hymerocromone [8].…”

Section: Introductionmentioning

confidence: 99%

Comparative Studies of Chromen Derivatives by Using Numerical Methods

Mesli¹,

Ghalem²

2017

Asian J. Chem.

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This study consists to develop program of molecular dynamics and to setup a method for calculations combined with ab initio (DFT and HF) to undertake theoretical investigations on products 4-hydroxy-chromen-2-one, 5,7-dihydroxy-4-methyl coumarin and 7-hydroxy-4-methyl coumarin. Studies were undertaken through a use of molecular program of dynamics for various both isothermal-isobaric NPT and canonical NVT of these products. It is showed that the classical approach gives good performances by means of simulation by molecular dynamics. Density functional theory calculations, B3LYP/6-31G, was performed for the determination of geometrical structure and vibrational assignment for the three systems. Full discussion of the framework vibrational modes was done using as criteria the study of the distorted geometric structures generated for each one of the vibrational modes in the low energy region. As results of this research we have obtained and characterized a novel 4-hydroxy-chromen-2-one, 5,7-dihydroxy-4-methyl coumarin, 7-hydroxy-4-methyl coumarin and we deduced the most probable structure using the experimental data of the infrared spectrum in conjunction with the theoretical DFT procedures. The calculated DFT spectra in the high and low energy regions agree well with the observed ones. The 4-hydroxy-chromen-2-one, 5,7-dihydroxy-4-methyl coumarin and 7-hydroxy-4-methyl coumarin were characterized by elemental analysis, IR, 1 H NMR and mass spectrometry. It is hoped that this model with a intermolecular reaction could be an effective starting material for studying the properties of complex system in polar solvent and apolaire.Keywords: Coumarin, Chromen, Biological activity, Molecular dynamics. Chemistry; Vol. 29, No. 7 (2017), 1405-1412 Coumarin present is in many perfumes and one finds the skeleton of coumarin in certain drugs such as the warfarin which is an anticoagulant. Several methods of synthesis are employed for the preparation of coumarins. We find in the literature the following reactions: Perkin [9], Pechmann [10], Knovennagel [11], Reformatsky [12] and Wittig [13]. The simplest cyclic coumarin is obtained mainly by the reaction of Pechmann. The latter consists of three stages: Reaction of cross esterification, followed by an intra-molecular reaction of hydroxy alkylation and ends in a reaction of dehydration. As the reaction is catalyzed, the acids most employed are of Brønsted. Coumarins are benzopyran derivatives. Naturally occurring coumarins have been isolated from over 800 species of plants and microorganisms [14] and many of these natural products exhibit useful drug like activity [15,16]. Moreover, coumarins are a group of compounds that play important roles as food constituents, antioxidants, stabilizers and immunomodulatory substances, as fluorescent markers for use in analyses, in stains and in clinical use [17,18]. Innovative frameworks are needed to integrate these data rich and diverse new for a systematic investigation of the determinants of the toxicity test, including chemical, biologic...

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Section: Introductionmentioning

confidence: 99%

Comparative Studies of Chromen Derivatives by Using Numerical Methods

Mesli¹,

Ghalem²

2017

Asian J. Chem.

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“…Malaria complicating hematological malignancies, such as leukemias and lymphomas, has been reported. [23] Although malaria is a recognized cofactor in the genesis of endemic Burkitt lymphoma, its role in acute leukemia is not known. [4]…”

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“…Malaria complicating hematological malignancies, such as leukemias and lymphomas, has been reported. [2,3] Although malaria is a recognized cofactor in the genesis of endemic Mixed Malarial Infection with Pancytopenia in a Child with Acute Lymphoblastic Leukemia: An Unusual Presentation…”

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confidence: 99%