Leukemia‐related transcription factor TEL/ETV6 expands erythroid precursors and stimulates hemoglobin synthesis

Eguchi‐Ishimae, Minenori; Eguchi, M.; Maki, Kazuhiro; Porcher, Catherine; Shimizu, Ritsuko; Yamamoto, Masayuki; Mitani, Kinuko

doi:10.1111/j.1349-7006.2009.01097.x

Cited by 14 publications

(11 citation statements)

References 40 publications

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“…20 However, other data have demonstrated that overexpression of ETV6 enhanced erythroid differentiation in cell models, 49 as well as leading to increased erythroid precursors, accelerated differentiation and augmented globin expression in mice transgenic for ETV6. 21 Our data are consistent with the latter studies, with etv6 morphants showing an initial decrease in gata1 expression, followed by a sustained increase in expression. However, despite this increase in early erythroid cells (and a parallel induction of epo) etv6 morphants remained anemic, with decreased β-e-g expression and increased erythroblasts in the blood.…”

Section: Discussionsupporting

confidence: 93%

“…20 In contrast, transgenic mice expressing human ETV6 under control of the Gata1 promoter showed accelerated proliferation of early erythroid progenitors, and increased erythroid differentiation. 21 Zebrafish is an established model for the study of hematopoiesis, showing broad conservation with mammalian species, including distinct primitive and definitive waves of development. 22 Zebrafish primitive hematopoietic progenitors are initially derived from hemangioblasts within the lateral plate mesoderm, 22 …”

Section: Introductionmentioning

confidence: 99%

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ETV6 (TEL1) regulates embryonic hematopoiesis in zebrafish

Rasighaemi¹,

Onnebo²,

Liongue³

et al. 2014

Haematologica

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

ETV6 (TEL1) regulates embryonic hematopoiesis in zebrafish

Rasighaemi¹,

Onnebo²,

Liongue³

et al. 2014

Haematologica

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“…Genes in this category are probably to be those which are more highly expressed during earlier developmental stages, being enriched for Hematologic System Development and Function (24 associated transcripts, P ϭ 1.55 ϫ 10 Ϫ5 ; Figure 2C). These include Ets variant 6 (ETV6), which has a role in expanding erythroid precursors and accumulating hemoglobin, 45 and hematopoietically expressed homeobox (HHEX) which regulates proliferation and differentiation of hemangioblasts and endothelial cells during ES cell differentiation. 46 The mouse homologue, Hhex, was rapidly down-regulated when erythroid differentiation was induced by GATA1 in G1ER cells.…”

Section: Org Frommentioning

confidence: 99%

Global gene expression analysis of human erythroid progenitors

Merryweather‐Clarke

Atzberger

Soneji

et al. 2011

Blood

120

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Understanding the pattern of gene expression during erythropoiesis is crucial for a synthesis of erythroid developmental biology. Here, we isolated 4 distinct populations at successive erythropoietindependent stages of erythropoiesis, including the terminal, pyknotic stage. The transcriptome was determined using Affymetrix arrays. First, we demonstrated the importance of using defined cell populations to identify lineage and temporally specific patterns of gene expression. Cells sorted by surface expression profile not only express significantly fewer genes than unsorted cells but also demonstrate significantly greater differences in the expression levels of particular genes between stages than unsorted cells. Second, using standard software, we identified more than 1000 transcripts not previously observed to be differentially expressed during erythroid maturation, 13 of which are highly significantly terminally regulated, including RFXAP and SMARCA4. Third, using matched filtering, we identified 12 transcripts not previously reported to be continuously upregulated in maturing human primary

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“…Over-expression of ETV6 was reported to suppress (29, 44, 45) or enhance (46) the megakaryocyte program different systems, the latter more easy to reconcile with the recent clinical findings. Disruption of ETV6 after the HSC commitment to the megakarycyte/erythroid lineage utilizing Gata1-Cre resulted in consistent, marked reduction of platelet counts (42).…”

Section: Etv6 In Megakaryocytic Developmentmentioning

confidence: 88%

ETV6 in hematopoiesis and leukemia predisposition

Hock

Shimamura

2017

Seminars in Hematology

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The ETV6 (also known as TEL) gene encodes a transcriptional repressor that plays a critical role in hematopoiesis and in embryonic development. While somatic ETV6 translocations and missense mutations are frequently observed in human cancers, the role of ETV6 in malignant transformation was unclear. Recently, autosomal dominant germline ETV6 mutations were discovered in families with inherited thrombocytopenia and a propensity to develop hematological malignancy, unequivocally demonstrating a role for ETV6 in leukemogenesis. Studies of germline ETV6 mutations also uncovered an important function of ETV6 in megakaryocyte development. Here we discuss our current understanding of the role of ETV6 in malignancy and in hematopoiesis.

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Leukemia‐related transcription factor TEL/ETV6 expands erythroid precursors and stimulates hemoglobin synthesis

Cited by 14 publications

References 40 publications

ETV6 (TEL1) regulates embryonic hematopoiesis in zebrafish

ETV6 (TEL1) regulates embryonic hematopoiesis in zebrafish

Global gene expression analysis of human erythroid progenitors

ETV6 in hematopoiesis and leukemia predisposition

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