Leukemia, Lymphoma, and Myeloma

Rosmarin, Alan G.

doi:10.1002/9781119645214.ch16

Cited by 5 publications

(1 citation statement)

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“…These include endothelial factors, platelets, coagulation cascade proteins, the fibrinolytic pathway, lymphoid and myeloid lineage cells, and various molecules associated with signaling pathways. These elements collectively contribute to the interplay between vascular biology and HL [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Potential Associations between Vascular Biology and Hodgkin’s Lymphoma: An Overview

Rodrigues,

Miguel,

Abreu

et al. 2023

Cancers

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Hodgkin’s lymphoma (HL) is a lymphatic neoplasm typically found in the cervical lymph nodes. The disease is multifactorial, and in recent years, the relationships between various vascular molecules have been explored in the field of vascular biology. The connection between vascular biology and HL is intricate and the roles of several pathways remain unclear. This review summarizes the cellular and molecular relationships between vascular biology and HL. Proteins associated with various functions in vascular biology, including cytokines (TNF-α, IL-1, IL-13, and IL-21), chemokines (CXCL10, CXCL12, and CCL21), adhesion molecules (ELAM-1/VCAM-1), and growth factors (BDNF/NT-3, platelet-derived growth factor receptor-α), have been linked to tumor activity. Notable tumor activities include the induction of paracrine activation of NF-kB-dependent pathways, upregulation of adhesion molecule regulation, genome amplification, and effective loss of antigen presentation mediated by MHC-II. Preclinical study models, primarily those using cell culture, have been optimized for HL. Animal models, particularly mice, are also used as alternatives to complex biological systems, with studies primarily focusing on the physiopathogenic evaluation of the disease. These biomolecules warrant further study because they may shed light on obscure pathways and serve as targets for prevention and/or treatment interventions.

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Section: Introductionmentioning

confidence: 99%