Leukemia Inhibitory Factor (LIF) induziert STAT3 DNA-Bindungsaktivität in JEG-3 Choriocarcinom Zellen

Fitzgerald, JS; Corvinus, Florian; Berod, Luciana; Pöhlmann, Tobias; Schleußner, E; Friedrich, Karlheinz; Markert, UR

doi:10.1055/s-2003-818184

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Intracellular Immunoregulatory Factors1

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2004

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“…STAT3 is present in a broad variety of cells and displays a wide range of functions. In T lymphocytes it is involved in the transcription of Th1 interleukins, in NK cells in perforin transcription and in invasive cells including trophoblast in their invasive behavior Fitzgerald et al, 2003). In T lymphocytes, the expression of Th1 related JAK and STAT molecules can be regulated through soluble substances from Jeg-3 choriocarcinoma cells, which represent the malignant transformation of trophoblast cells (Kilic et al, 1999).…”

Section: Intracellular Immunoregulatory Factorsmentioning

confidence: 99%