Leukemia Cutis Amidst a Psoriatic Flare

Abstract

Leukemia Cutis (LC) has many clinical morphologies that present a diagnostic challenge. This case report of a 58-year-old man experiencing a flare of psoriasis elucidates the need for clinical suspicion when a history of leukemia is present. A skin biopsy revealed histopathologic findings of psoriasis and an infiltrate of mononuclear cells consistent with LC. Upon review of the literature, 2 additional cases were reported of concurrent psoriasis and LC.

Salvage chemotherapy for the treatment of Leukemia cutis in a patient with acute monocytic leukemia

“…One of the well-known manifestations of extramedullary AML is leukemia cutis that occurs due to the infiltration of malignant neoplastic leukocytes originated from the bone marrow into different skin layers such as dermis, epidermis, and subcutis 7 . In patients with LC, clinical symptoms are variable which include macules, papules, neoformation with the nodular aspect, ulcers and plaques [8][9][10] . According to the literature, the most common lesions are macula and neoformation with nodular character 10 .…”