Leukemia and cancer in the same patient

Gunz, F. W.; Angus, Helen

doi:10.1002/1097-0142(196502)18:2<145::aid-cncr2820180204>3.0.co;2-a

Cited by 95 publications

(25 citation statements)

References 14 publications

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“…Previous studies have indicated an increased incidence of skin malignancies and NHL in the same patient (Gunz and Angus, 1965;Berg, 1967;Fraser ef al., 1971;Fletcher, 1973;Boland et al, 1976;Bellet el al., 1977;Travis et ai., 1992). Our study reports an increased incidence of skin cancers following NHL, and vice versa.…”

Section: Discussionmentioning

confidence: 93%

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Non‐Hodgkin's lymphoma and skin malignancies‐shared etiology?

Hall

Rosendahl

Mattsson

et al. 1995

Intl Journal of Cancer

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The Stockholm-Gotland Cancer Register was used to evaluate the clinical observation that patients with non-Hodgkin's lymphoma (NHL) had an increased risk of malignant melanoma or squamous-cell carcinoma of the skin (SCCS) and vice versa. During 1958-1992, NHL was diagnosed in a total of 6,176 patients. Of these patients, 504 developed a second primary cancer of any type except NHL, compared to 301.9 expected, giving a standardized incidence ratio (SIR) of 1.7 [95% confidence interval (CI) 1.5-1.8]. The risk of SCCS and malignant melanoma in patients with NHL was 4.8 (95% CI 3.6-6.2; n = 54) and 1.7 (95% CI 0.8-3.1; n = 10), respectively. The hazard risk for a second malignancy was relatively constant over time, whereas the skin malignancies revealed the highest risks 3-10 years after initial diagnosis. Similarly, the risk of a secondary NHL was studied in patients with malignant melanoma and SCCS during the same period and found to be 1.3 (95% CI 0.8-2.1; n = 17) and 1.8 (95% CI 1.2-2.5; n = 34), respectively. The highest risk for NHL following malignant melanoma was seen 3-10 years after first diagnosis, while the highest risk following SCCS was observed 0-2 years after initial diagnosis. One of several possible explanations or the development of NHL and a skin malignancy in the same patient is an immunological defect caused by sun exposure.

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Section: Discussionmentioning

confidence: 93%

“…It has previously been reported that the risk of a patient with non-Hodgkin's lymphoma (NHL) developing skin neoplasms later in life is increased (Gunz and Angus, 1965;Berg, 1967;McKinney et al, 1990;Travis et al, 1992). A similar increase in the risk of NHL in patients previously suffering from skin neoplasms has also been reported (Boland et at, 1976).…”

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confidence: 86%

Non‐Hodgkin's lymphoma and skin malignancies‐shared etiology?

Hall

Rosendahl

Mattsson

et al. 1995

Intl Journal of Cancer

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“…Prior studies of patients with CLL have documented increased risks of various forms of skin cancer, including malignant melanoma, 2,[8][9][10][11] probably resulting from the immune perturbations. 12 Risk of malignant melanoma is elevated in patients with therapeutic immune suppression associated with organ transplantation, and this risk is further enhanced by increases in sunlight exposure.…”

Section: Resultsmentioning

confidence: 99%

Solid tumors after chronic lymphocytic leukemia

Hisada

Biggar

Greene

et al. 2001

Blood

163

133

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“…Chronic lymphocytic leukemia (CLL) and acute granulocytic leukemia were the two types of malignant tumor of the hematopoietic system related to the highest incidence of second PMT—22.6 per cent and 17.6 per cent, respectively. The excessive incidence of cancer in patients with CLL is statistically significant, and cancers are not as prevalent with other leukemias or with lymphon 3–5,31–35 . The most frequent PMTs occurring with CLL are epitheliomas of the skin and lips.…”

Section: Discussionmentioning

confidence: 99%

Multiple Primary Malignant Tumors (MPMT): Study of 68 Autopsy Cases (1963–1980)

Lee

Myers

Scharyj

et al. 1982

J American Geriatrics Society

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Review of 8428 autopsies (1870 for known cancer) showed that 68 patients had had multiple primary malignant tumors (MPMT). Those 68 cases represented 0.8 per cent of all autopsies done, 3.6 per cent of all cancer autopsies. Diagnosis of MPMT was made only at autopsy in 24 cases (35.3 per cent). Thirty-six patients were male, 32 female. Their average age was 64 +/- 2.3 years. Cancers were "synchronous" (diagnosed within a six-month period) in 15 patients, "metachronous" (diagnosed at greater than six-month intervals) in 49, and "combined" in four. Metastatic foci were seen in 53 patients. Fifty-nine patients had two primary malignant tumors (PMTs); seven had three PMTs; one had four PMTs; and one had five PMTs, for a total of 148 tumors. Over half (53.1 per cent) of the second PMTs occurred within five years of the first PMTs. First PMTs were most common in the hematopoietic system and the cervix; second PMTs were most common in the lungs and the hematopoietic system. Second PMTs were less well differentiated than index PMTs. Forty-four deaths had not been directly tumor-related. Nineteen patients with metachronous MPMT lived more than ten years. Of 23 patients with one pulmonary PMT, 22 died within two years. Concomitant findings of pulmonary artery embolism, gallstone(s), thyroid or prostatic hyperplasia, and benign tumor were common in these patients. It is hoped that accumulation of data from this and other series of MPMT will provide insight into the clinicopathologic characteristics, the causes, and the interrelationships of these lesions that constitute primarily a disease of the elderly.

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Leukemia and cancer in the same patient

Cited by 95 publications

References 14 publications

Non‐Hodgkin's lymphoma and skin malignancies‐shared etiology?

Non‐Hodgkin's lymphoma and skin malignancies‐shared etiology?

Solid tumors after chronic lymphocytic leukemia

Multiple Primary Malignant Tumors (MPMT): Study of 68 Autopsy Cases (1963–1980)

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