Leukemia

McKenna, S.J.

doi:10.1067/moe.2000.102386

Cited by 36 publications

(19 citation statements)

References 4 publications

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“…ALL is the predominant leukaemia of childhood that runs an aggressive course and causes death within a few months if untreated 8 . The incidence of ALL in adults is relatively low 6 . The aetiology of most leukaemia is uncertain, although they are thought to be caused by a combination of environmental and genetic factors 2 .…”

Section: Discussionmentioning

confidence: 99%

Osteolytic mandible presenting as an initial manifestation of an adult acute lymphoblastic leukaemia

Chung

Kim

Choi

et al. 2011

International Journal of Oral and Maxillofacial Surgery

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Section: Discussionmentioning

confidence: 99%

Osteolytic mandible presenting as an initial manifestation of an adult acute lymphoblastic leukaemia

Chung

Kim

Choi

et al. 2011

International Journal of Oral and Maxillofacial Surgery

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“…1,2,3 During the conditioning regimen for haematopoietic stem cell transplantation (which includes total body irradiation or high-dose chemotherapy), and immediately after the transplant, patients may present a variety of symptoms, one of the most frequent and debilitating 4,5,6 of which is oral mucositis. The armamentarium for the management of oral mucositis consists of prophylactic and therapeutic measures, including topically and systemically applied non-pharmacological agents, as well as pharmacotherapeutics.…”

Section: Introductionmentioning

confidence: 99%

Clinical effectiveness of palifermin in prevention and treatment of oral mucositis in children with acute lymphoblastic leukaemia: a case–control study

et al. 2013

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The aim of this study was to evaluate the efficacy of palifermin, an N-terminal truncated version of endogenous keratinocyte growth factor, in the control of oral mucositis during antiblastic therapy. Twenty patients undergoing allogeneic stem-cell transplantation for acute lymphoblastic leukaemia were treated with palifermin, and compared to a control group with the same number of subjects and similar inclusion criteria. Statistical analysis were performed to compare the outcomes in the treatment vs. control groups. In the treatment group, we found a statistically significant reduction in the duration of parenteral nutrition (P=0.002), duration of mucositis (P=0.003) and the average grade of mucositis (P=0.03). The statistical analysis showed that the drug was able to decrease the severity of mucositis. These data, although preliminary, suggest that palifermin could be a valid therapeutic adjuvant to improve the quality of life of patients suffering from leukaemia.

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“…Untreated, acute leukemia has an aggressive course, with death occurring within 6 months or less. [1] The patient died in spite of our immediate referral because valuable time had been lost until the patient visited our department.…”

Section: Discussionmentioning

confidence: 99%

“…Leukemic cell multiplication at the expense of normal HP cell lines causes marrow failure, depressed blood cell count (cytopenia), and death as a result of infection, bleeding, or both. [1]…”

Section: Introductionmentioning

confidence: 99%

An undiagnosed case of acute myeloid leukemia

Babu¹,

Kashyap²,

Sivaranjani³

et al. 2014

J Indian Soc Periodontol

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Leukemia is a neoplastic disease characterized by an excessive proliferation of immature white blood cells and their precursors. Oral lesions may be the presenting feature of acute leukemia, which can be rapidly fatal if left untreated. Although many cases of gingival enlargement in patients with acute myeloid leukemia's have been reported in the literature, cases diagnosed by the oral manifestations in India are very few. This report describes the case of a 43-year-old female who presented with gingival bleeding and gingival enlargement. Within a month she developed signs and symptoms of systemic disease such as, and splenomegaly, and upon further investigation, she was diagnosed with acute myeloid leukemia to which she succumbed within 10 days after diagnosis. The need for early diagnosis and referral of this fatal disease are also underline.

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Leukemia

Cited by 36 publications

References 4 publications

Osteolytic mandible presenting as an initial manifestation of an adult acute lymphoblastic leukaemia

Osteolytic mandible presenting as an initial manifestation of an adult acute lymphoblastic leukaemia

Clinical effectiveness of palifermin in prevention and treatment of oral mucositis in children with acute lymphoblastic leukaemia: a case–control study

An undiagnosed case of acute myeloid leukemia

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