Leukaemic small cell variant anaplastic large cell lymphoma during pregnancy

Lesesve, Jean‐François; Buisine, J.; Grégoire, Marie-Josée; Raby, P; Léderlin, P.; Béné, Marie‐Christine; Froment, Nicolas; Labouyrie, Eric

doi:10.1046/j.1365-2257.2000.00144.x

Cited by 25 publications

(14 citation statements)

References 16 publications

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“…As previously described in literature (Kinney et al , ; Bayle et al , ; Lesesve et al , ), most cases in our series (6/9) included the presence of a small cell variant component. The presence of a small cell component, which may be recognized in 20–25% of ALK+ ALCL, has already been shown to be associated with a worse outcome (Lamant et al , ).…”

Section: Discussionsupporting

confidence: 69%

“…Bone marrow involvement in anaplastic large cell lymphoma (ALCL) is detected in about 10–14% of cases using standard analyses(Le Deley et al , ; Brugieres et al , ), but its detection increases to 30% following staining for CD30+, epithelial membrane antigen (EMA) and/or anaplastic lymphoma kinase (ALK) on bone marrow biopsy specimens (Fraga et al , ) and reaches 50% at diagnosis with techniques such as qualitative or quantitative polymerase chain reaction (PCR) for NPM1‐ALK , designed to detect minimal disseminated disease (Mussolin et al , ; Damm‐Welk et al , ,b). On the contrary, massive bone marrow involvement is rare and only a few cases of ALCL with leukaemic presentation have previously been published in children and adults (Bayle et al , ; Lesesve et al , ; Onciu et al , ; Grewal et al , ; Takahashi et al , ; Nguyen et al , ; Gadage et al , ; Kolenova et al , ; He & Viswanatha, ; Imamura et al , ). Although the 2‐year overall survival rate is about 90% in ALK‐positive ALCL (Brugieres et al , ), the prognosis of leukaemic ALCL seems to be unfavorable (Bayle et al , ; Onciu et al , ; Grewal et al , ; Takahashi et al , ; Nguyen et al , ; Gadage et al , ).…”

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confidence: 99%

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Paediatric anaplastic large cell lymphoma with leukaemic presentation in children: a report of nine French cases

et al. 2014

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Summary This study aimed to describe the clinical features and outcome of anaplastic large cell lymphoma (ALCL) with leukaemic presentation in children. Among 267 patients included in the French paediatric ALCL database between 1989 and 2012, nine (3%) were described as having cytologically detectable circulating tumour cells. Clinical features combined fever (8/9), nodal and extra‐nodal disease (9/9), including hepato‐splenic (9/9) and lung involvement (7/9). The level of hyperleucocytosis ranged from 30 to 120 × 109/l, with 12–90% of tumour cells. Diagnosis relied on a lymph node biopsy, with a positive ALK+ antibody immunostain in all nine cases, a T‐cell immunophenotype in 7/9 cases and CD3 positivity in 5/9 cases. A small cell component was present in 6/9 cases. Only four patients achieved a complete remission with first‐line therapy and 3/4 relapsed. Four patients are alive with a median follow‐up of 31 months, two of them after allogeneic haematopoietic stem cell transplantation (HSCT), and five patients died, two of them of disease. In conclusion, ALCL with leukaemic presentation is very unusual and should be considered as high‐risk lymphoma requiring new therapeutic strategies. The respective role of new agents and allogeneic HSCT in first complete remission still has to be assessed.

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Section: Discussionsupporting

confidence: 69%

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confidence: 99%

Paediatric anaplastic large cell lymphoma with leukaemic presentation in children: a report of nine French cases

et al. 2014

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“…Indeed, involvement of peripheral blood is rare in ALCL, whereas the small-cell variant, which represents only 8% (31/410) of ALCL (G Delsol, personal observations, 2003), may be more frequently associated with a leukemic phase. 5,[19][20][21][22][23] With the exception of 3 cases reported by Kinney et al, 5 the blood smears show predominantly small-to medium-sized lymphocytes with nuclear irregularities and basophilic cytoplasm. However, these cells may be extremely rare and are easily overlooked on superficial examination as in the present case.…”

Section: Discussionmentioning

confidence: 99%

Establishment of a novel anaplastic large-cell lymphoma-cell line (COST) from a ‘small-cell variant’ of ALCL

et al. 2004

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Anaplastic large-cell lymphoma (ALCL) is a distinct biological and cytogenetic entity with a broad spectrum of morphological features (common type, small-cell variant and lymphohistiocytic variant). Few cell lines of ALCL are available and they all originate from primary tumors demonstrating the common type morphology (ie large-sized lymphoma cells). We established a new ALCL cell line (COST) from the peripheral blood of a patient with a small-cell variant of ALCL, at diagnosis. Cells growing in vitro and in SCID mice consisted of two populations, that is, small-and large-sized cells as seen in the patient's tumor. Both large and small malignant cells were positive for CD43/MT1 T-cell associated antigen, perforin, granzyme B and TIA-1, but negative for CD2, CD3, CD5, CD7, CD4 and CD8 antigens. Standard cytogenetic studies as well as multiplex FISH confirmed the presence of the canonical t(2;5)(p23;q35) translocation, but also revealed additional numerical and structural abnormalities. The COST cell line is the first ALCL small-cell variant cell line, and thus provides a potentially useful tool for further functional and molecular studies that should improve our understanding of the small-cell variant of ALCL, which is more frequently complicated by a leukemic phase.

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“…In 2000, Lesesve et al 9 reported ALCL with leukaemic presentation and bone marrow involvement during the patient’s first trimester of pregnancy. In this case, therapeutic abortion was done followed by chemotherapy with CHOP.…”

Section: Discussionmentioning

confidence: 99%

Anaplastic large cell lymphoma in a pregnant Filipino woman successfully treated with prepartum and postpartum chemotherapy

2018

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Diagnosis of a malignancy during pregnancy presents a dilemma regarding the work-up and treatment of the patient. This report presents a 42-year-old woman on her 23rd week of pregnancy with multiple enlarging fungating violaceous skin masses. Biopsy of the dominant mass revealed anaplastic large cell lymphoma. Due to the progressive enlargement and increase in number of the masses, the patient was given two cycles of chemotherapy (doxorubicin, vincristine, cyclophosphamide and prednisone) before delivering a live baby boy via spontaneous vaginal delivery, Apgar 9.9, at 37 4/7 weeks. After delivery, she completed four more cycles of treatment. A full-body positron emission tomography scan done 2 months after the last chemotherapy showed no evidence of disease. The patient is doing well with no evidence of disease 9 months after treatment. Her baby is thriving and has no gross deformities and no developmental delays.

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Leukaemic small cell variant anaplastic large cell lymphoma during pregnancy

Cited by 25 publications

References 16 publications

Paediatric anaplastic large cell lymphoma with leukaemic presentation in children: a report of nine French cases

Paediatric anaplastic large cell lymphoma with leukaemic presentation in children: a report of nine French cases

Establishment of a novel anaplastic large-cell lymphoma-cell line (COST) from a ‘small-cell variant’ of ALCL

Anaplastic large cell lymphoma in a pregnant Filipino woman successfully treated with prepartum and postpartum chemotherapy

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