Abstract:Leucovorin (LCV) acts as an essential coenzyme for nucleic acid synthesis and also it is an active metabolite of folic acid. LCV can be used to selectively "rescue" cells from the adverse effects of methotrexate (MTX). Here, we report a case of LCV-induced hypersensitivity reaction when used in combination with high dose MTX (HDMTX). We describe a 2-yearsold female baby diagnosed with B-cell acute lymphoblastic leukemia on chemotherapy with pediatric berlin-frankfurtmunster protocol; she is on HDMTX and inject… Show more
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