Leucoreduction for preventing parasite transfusion‐transmission: an overlooked strategy

Jimenez‐Marco, Teresa; Girona-Llobera, Enrique

doi:10.1111/vox.12769

Cited by 3 publications

(1 citation statement)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two main strategies are being implemented to prevent the TTM in non-endemic and endemic areas including donor selection and laboratory screening [24]. Furthermore, the pathogen inactivation techniques and leukoreduction by filtration of whole blood (WB) and blood components could be efficient and safe technologies to reduce the risk of TTM [25][26][27][28][29].…”

Section: Malariamentioning

confidence: 99%

Prevention strategies of transfusion‐transmitted parasitic infections (TTPIs) in Iran, an endemic area for malaria, toxoplasmosis and leishmaniasis

Mardani

2019

ISBT Science Series

View full text Add to dashboard Cite

Background and Objectives Parasitic infections are one of the most important adverse reactions of blood transfusion. Several strategies are being implemented in blood transfusion centers of the world to prevent the transfusion-transmitted parasitic infections (TTPIs). The objective of this work was to clarify and describe the strategies to minimize the transmission risk of endemic parasitic agents in Iran via blood transfusion. Materials and MethodsThis study was conducted in the Iranian blood transfusion organization (IBTO). The data were extracted from the latest version of the "medical interview" standard operating procedure (SOP) and then recorded in the prepared sheets. ResultsThe donor selection is the first and only step to reduce the risk of TTPIs in endemic and non-endemic areas of Iran. In all blood transfusion centers of the IBTO, the blood donation volunteers with a previous history of malaria, Chagas disease, visceral leishmaniasis (VL), muco-cutaneous leishmaniasis and babesiosis, as well as those with toxoplasmosis, cutaneous leishmaniasis (CL) and with a history of residence in, or travel to, malaria-endemic areas are permanently or temporarily deferred from the blood donation. ConclusionFor some reasons, including the prevalence of malaria, toxoplasmosis and VL in parts of Iran, the donor selection strategy is not sufficient to prevent the TTPIs. Therefore, the changing of donor selection process and the use of other common preventive strategies are recommended to reduce the risk of TTPIs, especially for high-risk groups of toxoplasmosis and VL.

show abstract

Section: Malariamentioning

confidence: 99%

Prevention strategies of transfusion‐transmitted parasitic infections (TTPIs) in Iran, an endemic area for malaria, toxoplasmosis and leishmaniasis

Mardani

2019

ISBT Science Series

View full text Add to dashboard Cite

show abstract

Prevention strategies of transfusion-transmitted parasitic infections (TTPIs): Strengths and challenges of current approaches, and evaluation of the strategies implemented in Iran

Mardani

2020

Parasite Epidemiology and Control

View full text Add to dashboard Cite

Failure to Detect Leishmania in the Blood of Patients with Old-World Cutaneous Leishmaniasis: Implications for Blood Donation

Solomon

Gimple

Fuchs

et al. 2022

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Cutaneous leishmaniasis (CL) is endemic in Israel, caused mainly by Leishmania major (L. major) and L. tropica. In addition, returning travelers import another leishmanial species such as L. braziliensis. Although we are dealing with a skin disease, the blood bank in Israel does not accept blood donations from people infected with CL in cases of multiple lesions due to the possibility of transfusion. Our purpose was to investigate the prevalence of Leishmania in the blood of patients with active or previous CL. This pilot study screened patients with active or previous CL for parasites in their blood. All patients were infected in Israel or were returning travelers with leishmaniasis acquired in Latin America. Patients were seen at the Sheba Medical Center. In addition, patients were seen at their homes in L. tropica and L. major endemic regions in Israel. Blood samples were taken from each patient for culture and polymerase chain reaction (PCR). Altogether 62 blood samples were examined (L. tropica = 26, L. major = 33, and L. braziliensis = 3). Twenty-seven patients had an active disease and 35 were recovered. All blood cultures and PCR were negative for parasites except one blood sample that was PCR positive for L. braziliensis. The findings of our study, although a small sample, suggest that people with active or recent CL caused by L. major and L. tropica, do not harbor parasites in their blood. Thus, their exclusion from blood donation should be revisited. Further studies are needed with larger sample size and highly sensitive tests.

show abstract

Leucoreduction for preventing parasite transfusion‐transmission: an overlooked strategy

Cited by 3 publications

References 5 publications

Prevention strategies of transfusion‐transmitted parasitic infections (TTPIs) in Iran, an endemic area for malaria, toxoplasmosis and leishmaniasis

Prevention strategies of transfusion‐transmitted parasitic infections (TTPIs) in Iran, an endemic area for malaria, toxoplasmosis and leishmaniasis

Prevention strategies of transfusion-transmitted parasitic infections (TTPIs): Strengths and challenges of current approaches, and evaluation of the strategies implemented in Iran

Failure to Detect Leishmania in the Blood of Patients with Old-World Cutaneous Leishmaniasis: Implications for Blood Donation

Contact Info

Product

Resources

About