Leucoplasie verruqueuse proliférative : trois observations et revue de la littérature

Ottavioli, A.; Campana, F.; Catherine, Jean-Hugues; Massereau, E.; Grande, Jean Del; Ordioni, U.

doi:10.1016/j.annder.2015.12.010

Cited by 8 publications

(2 citation statements)

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“…After phase-1, 42 studies were assessed in full, of which 25 studies were excluded (Appendix S2), and 17 studies were included after phase 2 (Bagan, Murillo-Cortes, Leopoldo-Rodado, et al, 2019;Borgna et al, 2017;Favia et al, 2020;Fettig et al, 2000;Gandolfo et al, 2009;Garcia-Chias et al, 2014;Garcia-Pola et al, 2016;Kahn et al, 1994;McParland & Warnakulasuriya, 2020;Mehrotra et al, 2012;Ottavioli et al, 2016;Owosho et al, 2015;Saito et al, 1999;Thennavan et al, 2015;Upadhyaya et al, 2018;Villa et al, 2018;Zakrzewska et al, 1996) (Figure 1).…”

Section: Study Selectionmentioning

confidence: 99%

Malignant transformation of oral proliferative verrucous leukoplakia: A systematic review and meta‐analysis

et al. 2021

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Objectives:To investigate the available evidence on the malignant transformation (MT) of oral proliferative verrucous leukoplakia (PVL). Material and Methods:We searched six main electronic and three grey literature databases in a two-phase process. Cohort studies investigating MT of PVL were eligible for inclusion. The risk of bias (RoB) was assessed using a specific tool developed by the Joanna Briggs Institute. Proportion meta-analyses were performed using a random-effects model. Results:Study selection resulted in the inclusion of 17 studies. The pooled proportion of MT was 43.87% (95% CI = 31.93-56.13). Females (64.02%, 95% CI = 54.87-72.75) were more affected by PVL than males (35.98%, 95% CI = 27.25-45.13). Gingiva (39.6%) and buccal mucosa (21.6%) were the most frequent PVL sites. No conclusive results were found between MT and sex or age distribution, tobacco, or alcohol consumption. Gingiva was the most common site for MT (39.9%), and the most frequent histopathological subtype was conventional squamous cell carcinoma (62.1%). Four studies were classified as low, nine as moderate, and four as high RoB. Conclusion:The MT pooled proportion was 43.87%. Among OPMDs, PVL has the highest risk to transform to malignancy. Development and agreement on diagnostic criteria for PVL would reduce the heterogeneity among future studies.

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Section: Study Selectionmentioning

confidence: 99%

Malignant transformation of oral proliferative verrucous leukoplakia: A systematic review and meta‐analysis

et al. 2021

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“…32-34). Finally, 23 studies were included in the systematic review's final sample-23 for qualitative evaluation and 21 for quantitative meta-analysis- [5][6][7]22,[37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55].…”

Section: Results Of the Literature Searchmentioning

confidence: 99%

Prognosis Parameters of Oral Carcinomas Developed in Proliferative Verrucous Leukoplakia: A Systematic Review and Meta-Analysis

González‐Moles

Warnakulasuriya

Ramos‐García

2021

Cancers

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Proliferative verrucous leukoplakia (PVL) is contemplated by the World Health Organization (WHO) as an oral potentially malignant disorder (OPMD) with a high the highest malignant transformation ratio among all OPMD (approximately 50%). Our aim was to evaluate the current evidence in relation to the prognosis of oral carcinoma developed in patients with proliferative verrucous leukoplakia (PVL-OC). We searched PubMed, Embase, Web of Science and Scopus for published studies (upper date limit = June 2021). We evaluated the quality of studies (QUIPS tool). We carried out meta-analyses, examined inter-study heterogeneity through subgroup and meta-regression analyses, and performed sensitivity and small-study effects analyses to test the stability and reliability of results. 23 studies met inclusion criteria (505 patients with PVL, of which 288 developed a total of 504 carcinomas). The meta-analyzed overall mortality rate was 21.29% (pooled proportions [PP] = 95% confidence intervals [CI] = 8.77–36.36) for PVL-OC, clearly lower than the 34.7–50% mortality rate for conventional oral cancer reported in previous studies. In comparison with a single study reporting on conventional oral cancers, mortality was significantly lower for PVL-OC (hazard ratio = 0.29 [95%CI = 0.10–0.89], p = 0.03). Univariable meta-regression verified that case series that presented higher proportions of verrucous carcinomas showed a better survival of PVL-OC (p = 0.05), but not with higher proportion of oral squamous cell carcinomas (p = 0.74). Significant differences were not found for other relevant variables such as follow up period (p = 0.44) or multiple tumor development (p = 0.74). In conclusion, PVL-OC show favorable prognostic parameters, especially with regard to the mortality rate.

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Les lésions précancéreuses épithéliales buccales

Renaud-Vilmer

Cavelier‐Balloy

2017

Annales de Dermatologie et de Vénéréologie

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Leucoplasie verruqueuse proliférative : trois observations et revue de la littérature

Cited by 8 publications

References 49 publications

Malignant transformation of oral proliferative verrucous leukoplakia: A systematic review and meta‐analysis

Malignant transformation of oral proliferative verrucous leukoplakia: A systematic review and meta‐analysis

Prognosis Parameters of Oral Carcinomas Developed in Proliferative Verrucous Leukoplakia: A Systematic Review and Meta-Analysis

Les lésions précancéreuses épithéliales buccales

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