Leuconostoc bacteremia in a patient with amyloidosis secondary to rheumatoid arthritis and tuberculosis arthritis

Abstract

Leuconostoc infections are rare and usually occur in immunocompromised patients. This report describes a case of Leuconostoc lactis bacteremia in a patient with coexisting rheumatoid arthritis and tuberculosis arthritis. A disrupted gastrointestinal barrier due to gastrointestinal amyloidosis in long-standing rheumatoid arthritis and tuberculosis arthritis could be a risk factor for Leuconostoc bacteremia. Despite aggressive antibiotic treatment, the patient progressed to septic shock and multi-organ failure. The fatal course might have been caused by rapid progression of gastrointestinal pathology, which could be a risk factor for Leuconostoc bacteremia.

Bacteremia Due to Vancomycin-Resistant Leuconostoc lactis in a Patient With Pneumonia and Abdominal Infection

“…In the past, L lactis was not thought to be pathogenic to humans, but occasional cases of infections caused by this organism such as ventriculitis,3 osteomyelitis,4 and bloodstream infection2,5,6 have been reported in recent years. We have found only 3 cases of bacteremia caused by L lactis .…”

“…The identity was confirmed as L lactis by 16S rRNA gene partial sequencing. Universal bacterial primers 27F and 1494R were used for amplification 2. Purified DNA from the PCR was sequenced with BigDye Terminator Cycle sequencing kit (Applied Biosystems, Foster City, CA) and Applied Biosystems ABI PRISM 3730 genetic analyzer (Applied Biosystems Division).…”

“…Purified DNA from the PCR was sequenced with BigDye Terminator Cycle sequencing kit (Applied Biosystems, Foster City, CA) and Applied Biosystems ABI PRISM 3730 genetic analyzer (Applied Biosystems Division). All sequences were compared with those of similar strains using BLAST and EzTaxon 2. The isolates showed 98% sequence similarity to L lactis (GenBank Accession No.…”

“…Risk factors for infection by L lactis include central venous catheters, parenteral nutrition, surgery, liver failure, chronic renal insufficiency treated with hemodialysis, extensive burns, compromised immunity, and previous antibiotic therapy, particularly with vancomycin 2. The skin and digestive tract are believed to play important roles as routes of entry into the body.…”

Leuconostoc spp. Associated with Root Rot in Sugar Beet and Their Interaction with Rhizoctonia solani

“…Another advantage of using a DNAbased microarray approach may be to limit one's exposure to Leuconostoc spp. Leuconostoc spp., including L. mesenteroides and L. pseudomesenteroides, are emerging as human pathogens that can lead to severe infections, particularly in immunocompromised individuals (Albanese et al 2006;Bou et al 2008;Deng et al 2012;Kumudhan and Mars 2004;Shin et al 2011;Taneja et al 2005;Tas ‚kapilioglu et al 2011;Tholpady et al 2010;Wong et al 2012;Yang et al 2015). However, considering the rarity of Leuconostoc infections in people and the large presence of Leuconostoc spp.…”