Leucogenenol a thymothyroid hormone

Abstract

Thymectomy and, to a lesser extent, thyroidectomy cause a significant decrease in the serum leucogenenol levels of rats. Daily injections of neonatally thymectomized mice with leucogenenol causes the mice to maintain a normal level of neutrophils and lymphocytes in their circulation. The thymus and thyroid are the only tissues in rats and mice that afford radioactive leucogenenol when incubated in a medium containing radioactive D-glucose. It is concluded that the thymus and possibly the thyroid are responsible for the normal biosynthesis of leucogenenol in animals.

Chemistry of (glycidyloxy)propiolactones. An intramolecular transfer of alkoxy group in the alcoholysis and reduction reactions

“…(Glycidyloxy)propiolactones are a new group of organic compounds which can be obtained by the reaction of amethyl derivatives of glycidaldehyde 1 with aluminum alkoxides or alkylaluminium compounds.1"1 *3 45(See Figure 1).…”

“…7,8 The reduction of monosubstituted oxiranes yields a mixture of secondary and primary alcohols. The yields and proportions of products are, however, dependent upon the type of oxirane used and also on the type and concentration of the reducing agent employed.9,10 Epoxy aldehydes are reduced in the presence of sodium borohydride to epoxy alcohols, whereas in the presence of an excess of (1) Jedliñski, Z.; Kowalczuk, M. J. Org. Chem.…”