Leucocyte function in children with kwashiorkor.

Rosen, Eric; Geefhuysen, J; Joffe, Max I.; Rabson, Arthur R.

doi:10.1136/adc.50.3.220

Cited by 34 publications

(11 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is possible that both infection and undernutrition contribute to this impairment, though the role of the former was obviously much more significant since well nourished children with infection (group III) also showed a marked reduction in chemotactic migration (table IV). Data from another group are in conformity with our observations on chemotaxis (Rosen et al, 1975). The kinetics of the chemotactic response are significantly altered in kwashiorkor (Steven Douglas, personal communication).…”

Section: Discussionsupporting

confidence: 86%

Chemotaxis, random mobility, and mobilization of polymorphonuclear leucocytes in malnutrition.

Chandra¹,

Chandra²,

Op³

1976

J Clin Pathol

View full text Add to dashboard Cite

SYNOPSIS Neutrophil mobilization following administration of Pseudomonas polysaccharide was significantly reduced in malnutrition, especially during infection. The random mobility of polymorphonuclear leucocytes (PMNs) was slightly decreased in undernutrition. Chemotactic migration of PMNs was depressed and correlated more with the presence of infection than with nutritional deficiency. It is possible that these abnormalities of PMN mobilization and mobility in malnourished individuals contribute to suboptimal amount, kinetics, and pattern of tissue inflammatory response to bacteraemic challenge.

show abstract

Section: Discussionsupporting

confidence: 86%

Chemotaxis, random mobility, and mobilization of polymorphonuclear leucocytes in malnutrition.

Chandra¹,

Chandra²,

Op³

1976

J Clin Pathol

View full text Add to dashboard Cite

show abstract

“…Bacterial infections are a major determinant of morbidity and mortality in severe protein-energy malnutrition (1)(2)(3). Parameters contributing to this increased susceptibility to, and poor outcome of, infections in these children include thymolymphatic deficiency and subsequently deranged cellular immunity (4, 5 ) , depressed leukocyte count, chemotaxis and bactericidal capacity (6, 7), and a host of humoral derangements, including transferrin, (8) complement factor B, C3 and fibronectin (9) deficiencies.…”

mentioning

confidence: 99%

Serum C‐reactive protein and C3 complement protein levels in severely malnourished Nigerian children with and without bacterial infections

Ekanem

Raykundalia

et al. 1997

Acta Paediatrica

View full text Add to dashboard Cite

Bacterial infections are the major determinants of fatality in severe protein-energy malnutrition (PEM). Unfortunately, these infections are difficult to diagnose clinically. C-reactive protein (CRP) levels were determined in 17 infected and 10 non-infected Nigerian children with severe PEM and compared with age/sex-matched apparently healthy controls. The aim was to study the response of this acute phase protein to bacterial infections as well as to assess its value in the diagnosis of infections in severe PEM. C3 complement protein levels were also determined in the same group of subjects. The major organisms isolated in samples from these subjects were S. aureus and the coliforms. Mean CRP level in the non-infected children with severe PEM was 13.8 +/- 6.21 mg/l and rose to 159.83 +/- 124.07 mg/l in the presence of infection. The mean value in healthy non-infected controls was 2.01 +/- 0.96 mg/l. The difference in the mean CRP levels between the infected and non-infected PEM children was statistically significant at p < 0.01. The mean difference between the non-infected and the control subjects was not significant. Using a diagnostic level of 20.00 mg/l of CRP gave a sensitivity of 85.0% and a specificity of 80.0%. This CRP level is a useful index of bacterial infections in severe PEM. C3 complement protein was low in the non-infected malnourished group, but rose significantly in the presence of infection to values similar to that of the healthy controls. C3 protein thus behaves as an acute phase reactant in the presence of infection in severe PEM, and does not appear to be consumed, probably due to a deficiency in the early components of the complement cascade. This suggests a role for C3 measurement in the monitoring of bacterial infections in severe PEM.

show abstract

“…Abnormalities of phagocyte cell function in these patients are thus subtle. Often they appear to be a consequence of infection per se, rather than of the malnutrition per se (Douglas and Schopfer, 1974;Jose et at., 1975;Keusch et at., 1977a;Rosen et at., 1975;Seth and Chandra, 1972). Even in otherwise normal hosts, infections lead to quantitative defects in phagocytic cell function, perhaps because of mobilization of younger, functionally immature cells (McCall et at., 1969(McCall et at., , 1971.…”

Section: Effects Of Malnutrition On Susceptibility and Response To Inmentioning

confidence: 92%

Malnutrition and Infection

Keusch

Katz

1979

Nutrition

View full text Add to dashboard Cite

Leucocyte function in children with kwashiorkor.

Cited by 34 publications

References 13 publications

Chemotaxis, random mobility, and mobilization of polymorphonuclear leucocytes in malnutrition.

Chemotaxis, random mobility, and mobilization of polymorphonuclear leucocytes in malnutrition.

Serum C‐reactive protein and C3 complement protein levels in severely malnourished Nigerian children with and without bacterial infections

Malnutrition and Infection

Contact Info

Product

Resources

About