Leucocalocybe, a new genus for Tricholoma ongolicum (Agaricales, Basidiomycota)

Yu, Xiaodan

doi:10.5897/ajmr11.1228

Cited by 6 publications

(8 citation statements)

References 8 publications

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“…Yao (LM) is a wild mushroom that is of food value throughout East Asia and for medicine on account of its natural pharmaceutical products, such as ergosterol, ergosterol peroxide, polysaccharide, and lectins [1][2][3][4][5][6] . Recently, Yu et al 7 excluded this species from genus Tricholoma (L.) P.Kumm. and assigned it to a new monotypic genus Leucocalocybe X.D.…”

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Analyses of transcriptomes and the first complete genome of Leucocalocybe mongolica provide new insights into phylogenetic relationships and conservation

Duan

Bao

Bau

2021

Sci Rep

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In this study, we report a de novo assembly of the first high-quality genome for a wild mushroom species Leucocalocybe mongolica (LM). We performed high-throughput transcriptome sequencing to analyze the genetic basis for the life history of LM. Our results show that the genome size of LM is 46.0 Mb, including 26 contigs with a contig N50 size of 3.6 Mb. In total, we predicted 11,599 protein-coding genes, of which 65.7% (7630) could be aligned with high confidence to annotated homologous genes in other species. We performed phylogenetic analyses using genes form 3269 single-copy gene families and showed support for distinguishing LM from the genus Tricholoma (L.) P.Kumm., in which it is sometimes circumscribed. We believe that one reason for limited wild occurrences of LM may be the loss of key metabolic genes, especially carbohydrate-active enzymes (CAZymes), based on comparisons with other closely related species. The results of our transcriptome analyses between vegetative (mycelia) and reproductive (fruiting bodies) organs indicated that changes in gene expression among some key CAZyme genes may help to determine the switch from asexual to sexual reproduction. Taken together, our genomic and transcriptome data for LM comprise a valuable resource for both understanding the evolutionary and life history of this species.

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Analyses of transcriptomes and the first complete genome of Leucocalocybe mongolica provide new insights into phylogenetic relationships and conservation

Duan

Bao

Bau

2021

Sci Rep

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“…And in Chinese, we call it "Baimo" or "Kou-mo." But following phylogenetic analysis, the researcher Yao reclassified it as "Leucocalocybe mongolica" (Dong & Bau, 2013;Yu et al, 2011). L. mongolica is distributed in grassland of Inner Mongolia of China and it always form the fairy ring as shown in Figure 1 (Lu & Bau, 2017).…”

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confidence: 99%

Investigation of the possible mechanism of polysaccharides extracted from Leucocalocybe mongolica in exerting antitumor effects in H22 tumor‐bearing mice

2021

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A response surface method was used to optimize the extraction of polysaccharides from Leucocalocybe mongolica. Moreover, the preliminary structural characteristics and antitumor activity of L. mongolica polysaccharide (LMP) were investigated. The results showed that the optimized extraction technological parameters for LMP were 93°C extraction temperature, 5 hr extraction time, and 30 ml/g liquid-to-solid ratio. The LMP content extracted under the optimal conditions was 6.64%. LC-MS/ MS results indicated that LMP is a neutral polysaccharide composed of d-fructose, d-mannose, dextrose anhydrate, d-xylose, trehalose, and galactose. The tumor inhibition rate was significantly improved by LMP treatment. LMP had minimal toxicity based on the significant decrease in AST and BUN levels; VEGF protein levels were also significantly decreased. In contrast, the levels of IFNγ, IL-2, IL-6, and TNFα were improved. The results of ELISA, H&E staining, TUNEL assay, immunohistochemistry, and western blotting indicated that the LMP exhibited antitumor activity in vivo by promoting apoptosis, mediating inflammatory responses, and inhibiting angiogenesis. Practical applicationsAs one of the main bioactive components, fungal polysaccharide has always been a hot research topic. Fungal polysaccharides are carbohydrate polymers composed of monosaccharide units bound together by glycosidic linkages, which have been found to be involved in many biological processes. In this research, the LMP structure was analyzed, and the immunohistochemical and western blot analysis confirmed that, LMP could effectively reduce the generation of tumor angiogenesis, promote apoptosis of tumor cell sand inhibit tumor growth. The results of this study can effectively provide a basis for clinical research and development of antitumor drugs, and lay a foundation for the study of the antitumor effects of wild edible and medicinal fungi.

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“…Staude (Agaricales Basidiomycota) [2]. In the last decades, Tricholoma mongolicum S. Imai was moved from the genus Tricholoma to a newly established genus called Leucocalocybe, based on its molecular and morphological features [3]. L. mongolica has a short thick stem and white tiny spiny spores, the average size of spores (6.0 to 9.0 × 5.0 to 7.0 μM) ( Fig.…”

Section: Introductionmentioning

confidence: 99%

“…L. mongolica has a short thick stem and white tiny spiny spores, the average size of spores (6.0 to 9.0 × 5.0 to 7.0 μM) ( Fig. 1) [3]. However, L. mongolica consumes as edible food because it combines exquisite flavor and high nutritional value, which means this mushroom could be considered a cheap nutritional food source as a feasible alternative to meat for many countries.…”

Section: Introductionmentioning

confidence: 99%

Bioactive Compounds in <em>Leucocalocybe mongolica</em> Pharmacological and Therapeutic Applications

Haiying¹,

Mt²,

Ah³

2021

Preprint

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Medicinal mushrooms have got much attention from biologists in the last decades. Leucocalocybe mongolica Imai remains one of the famous clinical and edible mushrooms used in traditional Chinese medicine and Mongolian medicine to treat various diseases. It also commonly consumes in Chinese and Mongolian daily dishes. Numerous biochemical components exist in L. mongolica, especially in the fruiting bodies include; polysaccharides, sterol, lectins, laccase, amino acids, terpenes, volatile compounds, and so on. These biomedical components possess a lot of medicinal properties and provide diverse therapeutical effects for human health, such as anti-tumor activity, antiproliferative activity, anti-diabetes properties, hypotensive effect, hepatoprotective effect, antioxidant activity, cardioprotective effect, and so on. However, this review's main objectives are to illustrate some basics about the bioactive components in L. mongolica and its pharmacological effects on the human body. In addition to giving forward some suggestions for future research on this medicinal mushroom.

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Leucocalocybe, a new genus for Tricholoma ongolicum (Agaricales, Basidiomycota)

Cited by 6 publications

References 8 publications

Analyses of transcriptomes and the first complete genome of Leucocalocybe mongolica provide new insights into phylogenetic relationships and conservation

Analyses of transcriptomes and the first complete genome of Leucocalocybe mongolica provide new insights into phylogenetic relationships and conservation

Investigation of the possible mechanism of polysaccharides extracted from Leucocalocybe mongolica in exerting antitumor effects in H22 tumor‐bearing mice

Bioactive Compounds in <em>Leucocalocybe mongolica</em> Pharmacological and Therapeutic Applications

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