Leucine supplementation of a low-protein mixed macronutrient beverage enhances myofibrillar protein synthesis in young men: a double-blind, randomized trial

Churchward‐Venne, Tyler A.; Breen, Leigh; Donato, Danielle M. Di; Hector, Amy J.; Mitchell, Cameron J.; Moore, Daniel R.; Stellingwerff, Trent; Breuillé, Denis; Offord, Elizabeth; Baker, Steven K.; Phillips, Stuart M.

doi:10.3945/ajcn.113.068775

Cited by 245 publications

(250 citation statements)

References 46 publications

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“…The effect of the supplementation of a beverage with varying doses of leucine or a mixture of branched chain amino acids on myofibrillar protein synthesis after resistance exercise was assessed. Results showed that low-protein (6.25 g) beverage can be as effective as a high-protein dose (25 g) at stimulating myofibrillar protein synthesis rates when supplemented with a high (5 g) leucine content (Churchward-Venne et al 2014). As leucine comprises 10 % of the total whey amino acid, the latter appears important for augmenting muscle hypertrophy.…”

Section: Resistance Exercise and Muscle Synthesismentioning

confidence: 85%

Emerging trends in nutraceutical applications of whey protein and its derivatives

Patel

2015

J Food Sci Technol

129

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The looming food insecurity demands the utilization of nutrient-rich residues from food industries as valueadded products. Whey, a dairy industry waste has been characterized to be excellent nourishment with an array of bioactive components. Whey protein comprises 20 % of total milk protein and it is rich in branched and essential amino acids, functional peptides, antioxidants and immunoglobulins. It confers benefits against a wide range of metabolic diseases such as cardiovascular complications, hypertension, obesity, diabetes, cancer and phenylketonuria. The protein has been validated to boost recovery from resistance exercise-injuries, stimulate gut physiology and protect skin against detrimental radiations. Apart from health invigoration, whey protein has proved its suitability as fat replacer and emulsifier. Further, its edible and antimicrobial packaging potential renders its highly desirable in food as well as pharmaceutical sectors. Considering the enormous nutraceutical worth of whey protein, this review emphasizes on its established and emerging biological roles. Present and future scopes in food processing and dietary supplement formulation are discussed. Associated hurdles are identified and how technical advancement might augment its applications are explored. This review is expected to provide valuable insight on whey protein-fortified functional foods, associated technical hurdles and scopes of improvement.

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Section: Resistance Exercise and Muscle Synthesismentioning

confidence: 85%

Emerging trends in nutraceutical applications of whey protein and its derivatives

Patel

2015

J Food Sci Technol

129

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“…One can speculate whether MPS reached a ceiling effect in the current study. Consequently, reducing the protein dose to a suboptimal level could be a stronger design to investigate these differences [22,35]. A greater initial MPS after intake of whey would be considered an advantage for a quick recovery; however, this advantage might be short lived as the MPS after casein intake catches up after the first hours of recovery [8].…”

Section: Discussionmentioning

confidence: 99%

Native whey induces higher and faster leucinemia than other whey protein supplements and milk: a randomized controlled trial

et al. 2017

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Background: Resistance exercise and protein intake are both strong stimuli for muscle protein synthesis. The potential for a protein to acutely increase muscle protein synthesis seems partly dependent on absorption kinetics and the amino acid composition. The aim of this double-blinded randomized cross-over study was to compare time dependent changes in blood amino acid concentrations after ingesting 20 g of five distinct high quality dairy protein supplements (native whey, whey protein concentrate 80, hydrolysed whey, microparticulated whey, and milk proteins). Furthermore, we investigated whether differences in time dependent changes in blood amino acid concentrations affected acute blood glucose and urea responses, and recovery of muscle function after a bout of strength training. Methods: Ten young healthy, recreationally active men ingested different milk protein supplements after a whole-body strength training session on five occasions in a randomized manner. Blood concentrations of amino acids, glucose and urea was measured before and 0, 30, 45, 60, 90, 120 min, and 22 and 30 h post-exercise. Maximal voluntary isometric knee extension and counter movement jump were assessed before, immediately after, 6, 22 and 30 h after exercise.

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“…Son muchas las investigaciones que han estudiado los posibles efectos asociados a los suplementos de proteína y/o BCAAs en torno a la ganancia de masa muscular [16][17][18][19] , fuerza 20,21 , composición corporal de los sujetos [20][21][22] , atenuación de la fatiga 23,24 , reducción del dolor y daño muscular [25][26][27] y el efecto de la respuesta anabólica mediante la activación de una serie de enzimas que permiten el aumento de la síntesis de proteí-nas [28][29][30][31][32] .…”

Section: Materials Y Métodosunclassified

Efectos de los suplementos de proteína y aminoácidos de cadena ramificada en entrenamiento de fuerza: revisión bibliográfica

Rabassa-Blanco¹,

Palma-Linares²

2017

Rev Esp Nutr Hum Diet

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Introducción: Los suplementos de proteína y aminoácidos de cadena ramificada (BCAAs) son consumidos por la población buscando una serie de efectos fisiológicos y metabólicos sobre el rendimiento y recuperación, entre otros. Objetivo: Revisar las publicaciones más recientes que estudien los efectos del consumo de suplementos de proteína y BCAAs en entrenamiento de fuerza en diferentes parámetros fisiológicos y metabólicos. Material y Métodos:Estudio descriptivo de revisión bibliográfica. Se realizó una búsqueda específica de palabras clave en la base de datos PubMed y estrategia de bola de nieve. Criterios de inclusión: estudios realizados en humanos de ≥18 años sin patología, metaanálisis, revisiones sistemáticas y ensayos clínicos controlados aleatorizados en inglés y español relacionados con el consumo de suplementos de proteína y/o BCAAs en entrenamiento de fuerza y sus efectos sobre el daño muscular, respuesta anabólica en la recuperación muscular, ganancia de masa muscular y fuerza, composición corporal y fatiga.Resultados: 64 estudios identificados mediante la ecuación de búsqueda, 20 cumplieron con los criterios de inclusión. La media aritmética de los sujetos participantes fue igual a (30,59±24,47). Conclusiones:Los suplementos de proteína podrían tener un efecto positivo en el aumento del rendimiento y la masa muscular, pero hacen falta más estudios para esclarecer su posible beneficio sobre la composición corporal, la fatiga, la atenuación y reducción del dolor y daño muscular. La leucina tiene efecto en el aumento de la masa muscular y su función en población de edad avanzada. Los BCAAs podrían actuar sobre la atenuación de la fatiga central y en la mejora del rendimiento. PALABRAS CLAVE Introduction:The protein supplements and branched-chain amino acids (BCAAs) are consumed by all kinds of people to obtain a number of physiological and metabolic effects reversing improvements in performance and fast recovery among others. Objective: To perform an exhaustive review of the most recent scientific publications where it has studied the effects of consuming protein supplements and BCAAs in resistance training in different physiological and metabolic parameters. Material and Methods:Descriptive literature review. A specific keyword search was conducted in the PubMed database and snowball strategy. Inclusion criteria: studies in humans of ≥18 without pathology, meta-analysis, systematic reviews and randomized controlled trials in English and Spanish related to the consumption of protein supplements and/or BCAAs in resistance training and its effects on muscle damage, anabolic response in muscle recovery, gain muscle mass and strength, body composition and fatigue.Results: Out of the 64 studies identified by the search equation, 20 met the inclusion criteria. The arithmetic mean of the participating subjects is equal to (30.59±24.47). Conclusions:Protein supplements may have a positive effect on increasing muscle mass and performance, but further studies are needed to clarify their potential benefit on body ...

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Leucine supplementation of a low-protein mixed macronutrient beverage enhances myofibrillar protein synthesis in young men: a double-blind, randomized trial

Cited by 245 publications

References 46 publications

Emerging trends in nutraceutical applications of whey protein and its derivatives

Emerging trends in nutraceutical applications of whey protein and its derivatives

Native whey induces higher and faster leucinemia than other whey protein supplements and milk: a randomized controlled trial

Efectos de los suplementos de proteína y aminoácidos de cadena ramificada en entrenamiento de fuerza: revisión bibliográfica

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