Leucine-enkephalin-like immunoreactivity is localized in luteinizing hormone-producing cells in the axolotl (Ambystoma mexicanum) pituitary

Suzuki, Hirohumi; Yamamoto, Toshiharu

doi:10.1016/j.tice.2013.08.002

Tissue and Cell

2014

DOI: 10.1016/j.tice.2013.08.002

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Leucine-enkephalin-like immunoreactivity is localized in luteinizing hormone-producing cells in the axolotl (Ambystoma mexicanum) pituitary

Hirohumi Suzuki

Toshiharu Yamamoto

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Cited by 3 publications

(1 citation statement)

References 34 publications

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“…Tyrβ-Ala-Phe-Gly can be recognized by antisera 18 . Tyr-Gly-Gly-Phe-Leu was cyclic prodrug of the opioid peptide, which was shown to have high lipophilicity and low hydrogen bonding potential 19 . According to the above study, six peptides sequences Tyr-β-Ala, Tyr-β-Ala-Phe-Gly, Tyr-Gly-Gly-Phe-Leu, Tyr-Gly-Gly-Phe-Lys, Tyr-Gly-Gly-Phe-Leu-β-Ala and Tyr-Gly-Gly-Phe-Leu-Lys were chosen.…”

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confidence: 99%

Synthesis and Properties of Enkephalin Oligonucleotide Conjugates

Ma¹,

Zhu²,

Yao³

et al. 2014

Asian J. Chem.

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Oligonucleotide derivatives constitute a class of potential therapeutic agents that can be used to target double-stranded DNA, mRNA sequences and even proteins through specific recognition of base sequences and paired with the target sequence. However, the systemic therapeutic use of oligonucleotide is hindered by their poor cellular uptake, lack of stability in intracellular fluid, lack of target specificity and low binding affinity to the target 1-4. Overcoming these obstacles can be realized by many different ways. One approach is conjugation of the oligonucleotide to a peptide that has been suggested as cell delivery vehicles 5-8. Significantly, the oligonucleotides were shown to be taken up by cells when they functioned as noncovalent complexes or covalent conjugates of suitable peptides. Peptide fragments also gain some advantages upon conjugation to oligonucleotides, such as improvement of a certain peptide's ability to fine-tune the oligonucleotide cleavage activity 9. The chosen oligonucleotide CGCACACACGC was a synthetic apurinic undecamer contain 11-basepair, the welldefined system for structural studies 10. Among the miscellaneous peptides, the selected opioidenkephalin has many important physiological functions in animals, such as increase the resistance of immune system and antitoxic of lymphocytes 11-14. Tyrosine was the main amino acid residue for the degradation of enkephalin. Of the degraded

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confidence: 99%

Synthesis and Properties of Enkephalin Oligonucleotide Conjugates

Ma¹,

Zhu²,

Yao³

et al. 2014

Asian J. Chem.

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Localization of amylin-like immunoreactivity in melanocyte-stimulating hormone-containing cells of the pars intermedia but not those of the pars distalis in the axolotl (Ambystoma mexicanum) pituitary

Suzuki

Yamamoto

2016

Acta Histochemica

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Endogenous opiates and behavior: 2014

Bodnar

2016

Peptides

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Leucine-enkephalin-like immunoreactivity is localized in luteinizing hormone-producing cells in the axolotl (Ambystoma mexicanum) pituitary

Cited by 3 publications

References 34 publications

Synthesis and Properties of Enkephalin Oligonucleotide Conjugates

Synthesis and Properties of Enkephalin Oligonucleotide Conjugates

Localization of amylin-like immunoreactivity in melanocyte-stimulating hormone-containing cells of the pars intermedia but not those of the pars distalis in the axolotl (Ambystoma mexicanum) pituitary

Endogenous opiates and behavior: 2014

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