Leucemia cutis. Serie de 17 casos y revisión de la literatura

Martínez-Leboráns, L.; Victoria-Martínez, Ana Mercedes; Torregrosa-Calatayud, J.L.; Miquel, Víctor Alegre de

doi:10.1016/j.ad.2016.02.015

Cited by 29 publications

(20 citation statements)

References 12 publications

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“…1 The literature on LC has primarily been limited to studies that are largely descriptive, with small sample sizes, and/or with a histopathologic rather than a clinical focus. 2,[4][5][6][7][8][9][10][11][12][13] We therefore conducted this propensity score (PS)-matched cohort study to examine the patient factors associated with LC and the prognostic significance of LC in a patient's leukemic course, specifically in AML.…”

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Association of Leukemia Cutis With Survival in Acute Myeloid Leukemia

2019

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IMPORTANCE Leukemia cutis (LC) is an important yet understudied extramedullary manifestation of leukemia. Previous reports have suggested poor prognosis for patients with LC, but these reports have largely consisted of descriptive studies with a limited number of patients. OBJECTIVES To identify patient factors associated with LC and characterize the association of LC with the course of acute myeloid leukemia (AML). DESIGN, SETTING, AND PARTICIPANTS This retrospective, matched-cohort study included 1683 patients with AML diagnosed from January 1, 2005, to April 1, 2017, with and without biopsy-proven LC seen at a single-center, tertiary care hospital in St Louis, Missouri. To specifically evaluate differences in survival, propensity scoring was used to match patients with AML with LC to patients with AML without LC off the logit of propensity score based on age, race/ethnicity, sex, and leukemia type. Kaplan-Meier methods were used to compare cumulative probability survival. Matched survival analysis was performed with extended Cox regression to determine factors associated with leukemia-specific and overall survival. MAIN OUTCOMES AND MEASURES Leukemia-specific survival and overall survival. RESULTS A total of 1683 patients were reviewed, including 78 patients with biopsy-proven LC of the AML type and 1605 patients with AML without LC. A total of 62 of the patients with AML and LC (mean [SD] age, 58.2 [11.7] years; 33 [53.2%] male) were matched in a 1:3 ratio to 186 patients with AML without LC (mean [SD] age, 58.2 [13.5] years; 103 [55.4%] male). The 5-year survival among the 62 patients with AML with LC was 8.6%, shorter than the 28.3% among the 186 matched patients with AML without LC. Matched survival analysis revealed that patients with AML and LC compared with those without LC had hazard ratios of 2.06 (95% CI, 1.26-3.38; P = .004) for leukemia-specific death and of 1.66 (95% CI, 1.06-2.60; P = .03) for all-cause death. In addition, matched patients with LC had greater odds of extramedullary organ burden (odds ratio, 3.48; 95% CI, 1.72-7.05; P < .001). CONCLUSIONS AND RELEVANCE The results suggest that the presentation of LC in patients with AML is associated with decreased overall survival and leukemia-specific survival. Patients with AML presenting with LC may require more intensive treatment and monitoring of their leukemic disease.

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Association of Leukemia Cutis With Survival in Acute Myeloid Leukemia

2019

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“…La infiltración de la piel por células leucémicas se conoce como Leucemia cutis (LC) 1,2 . Aunque es difícil su diagnóstico hay que diferenciarla de la clínica cutá-nea secundaria a la pancitopenia, reacciones adversas a fármacos, síndromes paraneoplásicos, etc.…”

Section: Discusión Y Conclusionesunclassified

“…Aunque es difícil su diagnóstico hay que diferenciarla de la clínica cutá-nea secundaria a la pancitopenia, reacciones adversas a fármacos, síndromes paraneoplásicos, etc. (sin necesidad de infiltración por células leucémicas) 1 .…”

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“…La LC es una entidad poco frecuente, oscilando del 3-30% en función de la leucemia de base presentada. A pesar de la mayor prevalencia de leucemias linfoides crónicas (LLC), la infiltración cutánea es más habitual en la leucemia mieloide aguda (LMA), hasta un 10-15% de los casos, principalmente las monocíticas y mielomonocíticas agudas 1-3 y en la edad pediátrica 1 . Su fisiopatología aún está por determinar.…”

Section: Discusión Y Conclusionesunclassified

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Leucemia cutis. No todos los edemas son insuficiencia cardíaca

González-Merodio

Valle-González

Quera³

et al. 2022

Rev Esp Casos Clin Med Intern

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La leucemia cutis es una infiltración muy poco frecuente de células leucémicas de la piel. Su presentación clínica es muy variable y, en general, aparece posteriormente al compromiso de sangre periférica. Se asocia más frecuentemente con las leucemias monocíticas o mielomonocíticas y constituye un signo de enfermedad diseminada. Puede ser un marcador  de recidiva condicionando un mal pronóstico y una disminución de la supervivencia a corto y a largo plazo. La biopsia cutánea muestra infiltrados dérmicos perivasculares/perianexiales de linfocitos pequeños y monótonos, con inmunofenotipo característico de leucemia linfática crónica (CD20+, CD5+, CD23+, CD43+, CD10-, ciclina D1-).

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“…Acute myelomonocytic leukemia (AML M4) is a malignant-hematopoietic clonal sickness of bone marrow and disrupts production of normal blood cells [4]. Although there are many and various dermatological findings in AML, they are mostly due to cytopenia and haemostasis disorders and skin metastasis is not frequent [5].…”

Section: Introductionmentioning

confidence: 99%

Multiple skin metastases in a patient with acute myelomonocytic leukemia

Daye¹

2019

Our Dermatol Online

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Metastatic skin tumors may occur before or at any time before the diagnosis of malignancy. Skin metastases are thought to be indicative of advanced stage malignancy or non-treatment response. Cutaneous metastases are a worse prognostic mark, especially in patients with cancer of the lung, ovary, upper respiratory tract, or upper digestive tract. Acute myelomonocytic leukemia is a malignant-hematopoietic clonal sickness of bone marrow and disrupts production of normal blood cells. Although there are many and various dermatological findings in acute leukemia, they are mostly due to cytopenia and haemostasis disorders and skin metastasis is not frequent. Here, we present a case of skin involvement with a diagnosis of acute myelomonocytic leukemia, which is uncommon in the literature and nodules on the whole body.

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Leucemia cutis. Serie de 17 casos y revisión de la literatura

Cited by 29 publications

References 12 publications

Association of Leukemia Cutis With Survival in Acute Myeloid Leukemia

Association of Leukemia Cutis With Survival in Acute Myeloid Leukemia

Leucemia cutis. No todos los edemas son insuficiencia cardíaca

Multiple skin metastases in a patient with acute myelomonocytic leukemia

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