Leucemia cutis desarrollada en la zona de inoculación de una dosis de recuerdo de la vacuna del tétanos

Guinovart, R.M.; Carrascosa, J.M.; Ferrándiz, Carlos

doi:10.1016/j.ad.2010.03.017

Cited by 4 publications

(7 citation statements)

References 9 publications

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“…The diagnosis is confirmed by skin biopsy and immunohistochemistry [2]. In most cases, there are perivascular or diffuse infiltrate, which affect dermis and subcutaneous tissue, but don't affect the upper part of papillary dermis [3]. Nevertheless, histological findings can be very variable and don't always correlate with clinical findings [2,4].…”

Section: Discussionmentioning

confidence: 99%

“…Acute myeloid leukemia is the type of leukemia where this clinical manifestation is more often found, with an incidence between 2.9 and 3.7%. This incidence can be increased to 10-50% in case of myelomonocytic leukemia (AML-M4) and monocytic leukemia (AML-M5); which are also associated with gingival and meningeal infiltration [1,3,[6][7][8]. Some studies suggest that monocytes have biological characteristics that provide them with greater adhesive, phagocytic and deformable capacity, compared to other white blood cells.…”

Section: Discussionmentioning

confidence: 99%

“…Leukemia cutis is associated with extramedullary involvement in other locations, and also with specific cytogenetic mutations. It is a sign of poor prognosis, with a life expectancy between 1.3 and 3.6 months after its diagnosis [2][3][4][5][6]8]. It is also associated with a higher rate of recurrence, which suggests that skin lesions can be used as a reservoir for neoplastic cells, as a way to protect themselves from various treatments [1,5].…”

Section: Discussionmentioning

confidence: 99%

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A Case of Leukemia Cutis in an Inguinal Herniorraphy Scar

Duarte¹,

Nieto²,

Estruch³

et al. 2020

SCR

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Leukemia cutis refers to the infiltration of the skin with leukemia cells. It is a rare extramedullary manifestation of leukemia, but it is a specific sign of disease progression and bad prognosis. Cases of leukemia cutis in sites of skin trauma or surgical scars have been described, but there are very few cases reported in literature. We report a case of a 65-year-old male previously diagnosed with chronic myelomonocytic leukemia that was showing clinical signs of progression to acute myeloid leukemia. He underwent right inguinal herniorrhaphy three months before and was showing poor wound healing. Surgical site infection was suspected, since blood tests showed prolonged neutropenia, so surgical wound debridement was performed. Pathological findings of removed tissue indicated infiltration by leukemic cells, which led to the diagnosis of leukemia cutis, not suspected until that moment. Therefore, we conclude that an exhaustive skin examination (especially in the presence of skin trauma or surgical scars), should be performed in patients with confirmed or suspected diagnosis of leukemia. Moreover, the possible diagnosis of leukemia cutis should be considered in leukemia patients who present cutaneous infectious complications or suboptimal healing following accidental skin trauma or surgery. In these cases, complementary anatomopathological studies should be performed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A Case of Leukemia Cutis in an Inguinal Herniorraphy Scar

Duarte¹,

Nieto²,

Estruch³

et al. 2020

SCR

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“…El pronóstico de la LMMC empeora en relación a la intensidad de la anemia, el grado de leucocitosis y la afectación de diferentes órganos y tejidos pudiendo evolucionar a leucemia aguda en un 15-30% de casos [1] Se denomina "leucemia cutis" a la infiltración cutánea por células malignas de origen hematopoyético [6][7][8][9]. Los primeros casos de infiltración cutánea por LMMC fueron descritos por Duguid et al en 1983 [10].…”

Section: Comentariounclassified

“…La leucemia mielomonocítica crónica (LMMC) es un proceso oncohematológico con características mieloproliferativas y mielodisplásicas [1][2][3][4]. La infiltración cutánea específica por células malignas hematopoyéticas de la LMMC denominada "leucemia cutis" es un signo de mal pronóstico y comportamiento agresivo de la enfermedad, de presentación infrecuente y casi siempre asociado a una transformación blástica y a una agudización de la leucemia [2,[5][6][7][8][9]. Presentamos tres casos de pacientes varones diagnosticados de "leucemia cutis" en el contexto de LMMC, dos de los cuales evolucionaron a leucemia aguda falleciendo en un breve periodo de tiempo tras su agudización.…”

Section: Introductionunclassified