Leu-enkephalin provokes naloxone-insensitive pulmonary vasoconstriction

Endogenous Opioids as Mediators of Asthma

“…[65][66][67] kephalin may have direct vasoconstrictory effects on In human tissues, it was shown that OP 3 ( ) opioid the pulmonary circulation of isolated perfused rat ligands reduce cholinergic responses to electric field lungs that may not be mediated by conventional stimulation (EFS), presumably by inhibiting the reopiate receptors. 76 Another study reported that Leu5-lease of acetylcholine from the postganglionic paraenkephalin is a weak pulmonary vasoconstrictor in sympathetic nerve fibres that innervate airway smooth the lamb and that this effect does not seem to be due muscles. 68 to a direct effect on pulmonary vessels by Leu5-Recently it has been reported that the novel opioid enkephalin, but may be effected through neural or nociceptin inhibits EFS stimulated cholinergic parahormonal mediators.…”