Lettuce allergy: sensitizing potency of allergens

Andersen, Knud Erik; Helander, I; Gensch, K. H.

doi:10.1111/j.1600-0536.1986.tb01350.x

Cited by 21 publications

(26 citation statements)

References 11 publications

(7 reference statements)

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“…Altogether, the results support the suggestion by Hausen et al. in 1986 that lactucin is a stronger sensitizer than lactucopicrin in humans . In addition to the two Danish studies, in which lettuce contact allergy was also diagnosed by patch testing with plant material ‘as is’, oleoresins, and an ether extract, Kanerva et al.…”

Section: Diagnosissupporting

confidence: 84%

“…As mentioned above, Hausen et al. could not explain the discrepancy between the positive reactions to lactucin in the 2 patients and the fact that lactucopicrin seemed to be a stronger sensitizer in an experimental animal study . Mitchell et al.…”

Section: Diagnosismentioning

confidence: 88%

“…Among this array of SLs occurring in lettuce, only two have been proved to be allergenic: lactucin and lactucopicrin . Both a short ether extract of lettuce and the pure SLs were found to be relatively weak sensitizers in both animal and clinical studies .…”

Section: Allergensmentioning

confidence: 99%

“…Concerning testing with leaves, the results were not consistent: 2 patients reacted positively to leaf wetted with water and 1 to leaf wetted with ethanol (Table ). Strongly positive patch test reactions to lettuce leaves have been reported, but the reactions probably reflect the fact that the patients were highly sensitive after occupational exposure (,,,,,,). Furthermore, Krook reported on a lettuce gardener who only had skin problems after exposure to full‐grown plants; this is in accordance with the fact that the concentration of SLs increases on bolting (,).…”

Section: Diagnosismentioning

confidence: 99%

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Lettuce contact allergy

Paulsen

Andersen

2015

Contact Dermatitis

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SummaryLettuce (Lactuca sativa L.) and its varieties are important vegetable crops worldwide. They are also well-known, rarely reported, causes of contact allergy. As lettuce allergens and extracts are not commercially available, the allergy may be underdiagnosed. The aims of this article are to present new data on lettuce contact allergy and review the literature. Lettuce is weakly allergenic, and occupational cases are mainly reported. Using aimed patch testing in Compositae-allergic patients, two recent Danish studies showed prevalence rates of positive lettuce reactions of 11% and 22%. The majority of cases are non-occupational, and may partly be caused by cross-reactivity. The sesquiterpene lactone mix seems to be a poor screening agent for lettuce contact allergy, as the prevalence of positive reactions is significantly higher in non-occupationally sensitized patients. Because of the easy degradability of lettuce allergens, it is recommended to patch test with freshly cut lettuce stem and supplement this with Compositae mix.

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Section: Diagnosissupporting

confidence: 84%

Section: Diagnosismentioning

confidence: 88%

Section: Allergensmentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

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Lettuce contact allergy

Paulsen

Andersen

2015

Contact Dermatitis

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“…If one chooses to test the patient with fresh plants, then there is, depending upon the species, a risk of severe, possibly bullous reactions due to high content of allergens, false positive reactions owing to local irritant properties or false negative reactions because of a low content of allergens (degradation products) (21). In a recent Swedish investigation (13), however, close agreement was found between the results of testing with plants as is (fresh and frozen) and with extracts.…”

Section: Allergens and Diagnosismentioning

confidence: 99%

Compositae dermatitis: a survey

Paulsen

1992

Contact Dermatitis

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Compositae dermatitis in an allergic contact dermatitis, frequently chronic, triggered by plants of the Compositae family. The condition, which is seen, in particular, in middle-aged and elderly persons, typically starts in the summer months with an acute eczema either corresponding to areas exposed to light and air, or corresponding to areas of plant contact; it disappears spontaneously during the fall of the year. Repeated exposure over a number of years may cause severe intractable dermatitis affecting the patient throughout the year. The responsible allergens are sesquiterpene lactones, and investigations to date indicate that the frequency of the allergy is similar to that seen with some of the contact allergens of the standard patch test series. The diagnosis, however, is difficult, partly due to the fact that the clinical picture may be mistaken for a photodermatosis, and partly owing to the difficulty in obtaining commercially available allergens for patch testing. The diagnosis is therefore based on testing with plant extracts, which can cause pronounced local reactions and possibly active sensitization. A survey is given of the possible modes of sensitization, sex and age distribution, the relationship to photosensitivity and atopy, as well as the possible treatment. It is conclude~, on the basis of the chronic nature of the disease, and the diagnostic and treatment problems, that continued intensive research into the condition is urgently needed.

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Sesquiterpenlactone [MAK Value Documentation in German language, 2006]

2012

The MAK‐Collection for Occupational Health and Safety

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Lettuce allergy: sensitizing potency of allergens

Cited by 21 publications

References 11 publications

Lettuce contact allergy

Lettuce contact allergy

Compositae dermatitis: a survey

Sesquiterpenlactone [MAK Value Documentation in German language, 2006]

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