Letters to the editor

Lane, D. C.; McGuire, John; Depke, Gisbert; Klose, W.; Schwarz, Helmut

doi:10.1002/oms.1210181108

Cited by 15 publications

(5 citation statements)

References 8 publications

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“…Moreover, the use of ion/molecule reactions to ionize a compound of interest often results in concentration of the total ion current among a few structurally relevant product ions rather than the broad distribution of ion current among the many fragment ions typically produced by conventional electron ionization (5). An increasing number of studies have focused on the examination of alternative chemical ionization agents, including both organic (6)(7)(8)(9)(10)(11)(12)(13)(14) and metallic (15)(16)(17)(18) reagents. The growing interest in characterizing new chemical ionization agents stems not only in part from its analytical utility but also due to the increasing availability and rapidly developing capabilities of two ion-trapping instruments, Fourier transform ion cyclotron resonance (FT1CR) (19) and quadrupole ion trap mass spectrometers (20).…”

Section: Introductionmentioning

confidence: 99%

Selective adduct formation by dimethyl ether chemical ionization in a quadrupole ion trap mass spectrometer and a conventional ion source

Brodbelt¹,

Liou²,

Donovan³

1991

Anal. Chem.

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Section: Introductionmentioning

confidence: 99%

Selective adduct formation by dimethyl ether chemical ionization in a quadrupole ion trap mass spectrometer and a conventional ion source

Brodbelt¹,

Liou²,

Donovan³

1991

Anal. Chem.

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“…Moreover, reactive intermediates can occasionally be characterized. These well-known features of ion chemistry have prompted, inter alia, investigation of the gas-phase methylation and halomethylation of hydroxyaromatic compounds (45,46).…”

Section: Resultsmentioning

confidence: 99%

Chemical ionization in an ion trap mass spectrometer

Brodbelt¹,

Louris²,

Cooks³

1987

Anal. Chem.

103

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“…This kind of reaction has been observed previously mainly for aromatic compounds and cycloalkenes. [23][24][25] From the CD 3 I CI mass spectra it can be concluded that either one of the lost hydrogen atoms must be derived from the fused reagent ion. In the pentanal CH 3 I CI spectrum the base peak was at m/z 58, which is the base peak also in the low-energy, low-temperature EI mass spectra of pentanal.…”

Section: Reactions With Ketones and Aldehydesmentioning

confidence: 99%

“…[19][20][21][22] As a curiosity, the formation of [M + 13] + ion especially for aromatic compounds has attracted interest. [23][24][25] Highpressure radiolytic techniques have also been applied to study the chemistry of dimethylhalogenium ions in the gas phase. [26][27][28][29][30][31][32][33][34][35] At present methyl halides are not widely used as CI reagent gases and systematic studies of the basic reactions of these compounds towards different classes of compounds are lacking.…”

mentioning

confidence: 99%

Methyl Iodide—An Interesting Reagent for Positive Ion Chemical Ionization

Partanen

Vainiotalo

1997

Rapid Commun. Mass Spectrom.

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Methyl iodide (CH 3 I) has been used as a chemical ionization reagent gas and the ion/molecule reactions of formed reagents ions with a number of nucleophiles were studied in a chemical ionization source of a conventional mass spectrometer. Generalizing, charge exchange reactions dominate for compounds with lower ionization energy than CH 3 I, while the others preferred protonation and methylation reactions. For ketones both protonation and charge exchange reactions were thermodynamically possible and the prevailing reaction was dependent on the compound. Surprisingly, all the isomeric C 5 ketones gave rise to clearly different spectra. Alcohols, having higher ionization energies than CH 3 I and a lower proton affinity than that of CH 2 I• , also reacted interestingly. Ionization through hydroxide abstraction prevailed for C 3 -C 6 alkanols. Chemical ionization (CI) mass spectrometry is an adaptable method for examining ion/molecule reactions in the gas phase. In addition, molecular weight and structural information can be obtained by a suitable choice of reagent gas. The gas-phase reactions between alkyl halides and various nucleophiles have aroused interest for a long time. The reasons for this may be that in the condensed phase alkyl halides are known to be good substrates for nucleophilic substitution, one of the most useful class of organic reactions. The main topics in the area of gas-phase ion/ molecule chemistry of methyl and ethyl halides are the unimolecular chemistry of the pure alkyl halide, [1][2][3][4] reactions of alkyl halides with various nucleophiles [5][6][7][8] and especially the site of cation attachment in the course of electrophilic addition reactions.9-18 The regioand stereoselective reactions of alkyl halides towards geometric isomers have also been probed. [19][20][21][22] As a curiosity, the formation of [M + 13] + ion especially for aromatic compounds has attracted interest. [23][24][25] Highpressure radiolytic techniques have also been applied to study the chemistry of dimethylhalogenium ions in the gas phase.

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Letters to the editor

Cited by 15 publications

References 8 publications

Selective adduct formation by dimethyl ether chemical ionization in a quadrupole ion trap mass spectrometer and a conventional ion source

Selective adduct formation by dimethyl ether chemical ionization in a quadrupole ion trap mass spectrometer and a conventional ion source

Chemical ionization in an ion trap mass spectrometer

Methyl Iodide—An Interesting Reagent for Positive Ion Chemical Ionization

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