Letters for J R Army Med Corps 2008; vol 154

doi:10.1136/jramc-154-01-21

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…Detailed three-dimensional structural information is provided by CT scanning with the vessels perfused with contrast resin at killing [2, 34], or in vivo [20, 26, 30, 31], but these are often limited snapshots at particular time points and provide no information of the time course of neovascularisation. For example, Tomlinson and associates [40] used silicone contrast perfusion of vessels and micro-computer tomography (micro-CT) scanning of forelimb stress fractures at 3 and 7 days after loading-induced stress fractures.…”

Section: Introductionmentioning

confidence: 99%

Characterising neovascularisation in fracture healing with laser Doppler and micro-CT scanning

Macdonald

Shefelbine

2013

Med Biol Eng Comput

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Vascularity of the soft tissues around a bone fracture is critical for successful healing, particularly when the vessels in the medullary canal are ruptured. The objective of this work was to use laser Doppler and micro-computer tomography (micro-CT) scanning to characterise neovascularisation of the soft tissues surrounding the fracture during healing. Thirty-two Sprague–Dawley rats underwent mid-shaft osteotomy of the left femur, stabilised with a custom-designed external fixator. Five animals were killed at each of 2, 4 days, 1, 2, 4 and 6 weeks post-operatively. Femoral blood perfusion in the fractured and intact contralateral limbs was measured using laser Doppler scanning pre- and post-operatively and throughout the healing period. At sacrifice, the common iliac artery was cannulated and infused with silicone contrast agent. Micro-CT scans of the femur and adjacent soft tissues revealed vessel characteristics and distribution in relation to the fracture zone. Blood perfusion dropped immediately after surgery and then recovered to greater than the pre-operative level by proliferation of small vessels around the fracture zone. Multi-modal imaging allowed both longitudinal functional and detailed structural analysis of the neovascularisation process.

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Section: Introductionmentioning

confidence: 99%

Characterising neovascularisation in fracture healing with laser Doppler and micro-CT scanning

Macdonald

Shefelbine

2013

Med Biol Eng Comput

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Caspases in retinal ganglion cell death and axon regeneration

et al. 2017

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Retinal ganglion cells (RGC) are terminally differentiated CNS neurons that possess limited endogenous regenerative capacity after injury and thus RGC death causes permanent visual loss. RGC die by caspase-dependent mechanisms, including apoptosis, during development, after ocular injury and in progressive degenerative diseases of the eye and optic nerve, such as glaucoma, anterior ischemic optic neuropathy, diabetic retinopathy and multiple sclerosis. Inhibition of caspases through genetic or pharmacological approaches can arrest the apoptotic cascade and protect a proportion of RGC. Novel findings have also highlighted a pyroptotic role of inflammatory caspases in RGC death. In this review, we discuss the molecular signalling mechanisms of apoptotic and inflammatory caspase responses in RGC specifically, their involvement in RGC degeneration and explore their potential as therapeutic targets.

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Aspects of ocular war injuries

Scott

Morgan-Warren

2014

Trauma

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Eye injuries are common in warfare with an incidence of approximately 10%. They carry a high morbidity, as they can determine an injured person’s future independence and employability. The majority are a combination of primary and secondary blast mechanisms, though tertiary and quaternary types are common. There is some evidence of quinary types from toxic elements from the explosion. Eye protection significantly reduces the incidence and severity of ballistic eye injury but does not eliminate it. Thermal ocular burns are relatively common in warfare. The treatment goal is to minimise limbal stem cell damage. Human amniotic membrane can be used to promote this. Retinal and optic nerve injury following closed eye trauma are currently untreatable, but neuroprotective and neuroregenerative agents are being developed to improve outcomes. Sensory substitution of the sense of touch for sight can help orientate blinded individual in their surroundings. Ophthalmology has a major impact on the lives of the war wounded.

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Letters for J R Army Med Corps 2008; vol 154

Cited by 3 publications

References 11 publications

Characterising neovascularisation in fracture healing with laser Doppler and micro-CT scanning

Characterising neovascularisation in fracture healing with laser Doppler and micro-CT scanning

Caspases in retinal ganglion cell death and axon regeneration

Aspects of ocular war injuries

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