Letter: vitamin D supplementation and the irritable bowel syndrome

Karaahmet, Fatih; Başar, Ömer; Yksel, I.; Yüksel, Osman

doi:10.1111/apt.12188

Cited by 9 publications

(7 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is no doubt a questionable fact whether vitamin D deficiency could be taken into account as a causative factor relating to the pathogenic aetiology in the development of IBS as in the case of vitamin deficiency induced fibromyalgia cases. 14 The present study has shown significant difference in the mean level of vitamin D in the IBS group compared to control. It is worth mentioning that the authors see no published clinical study that looks into the pathological explanation of such an association.…”

Section: Discussionsupporting

confidence: 47%

Vitamin D Deficiency in Patients with Irritable Bowel Syndrome: Does it Exist?

Khayyat¹,

Attar²

2015

Oman Med J

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 47%

Vitamin D Deficiency in Patients with Irritable Bowel Syndrome: Does it Exist?

Khayyat¹,

Attar²

2015

Oman Med J

View full text Add to dashboard Cite

show abstract

“…In vitro studies have shown that both soy phytoestrogens and vitamin D can strengthen each other to bind ERs in smooth muscle cells and modulate the expression of ER proteins[ 24 ]. Besides the impact of these nutrients on the specific receptors in colonic tissue, they may affect the psychological items of IBS and soothe the chronic visceral pain [ 25 ]. Moreover, vitamin D is an essential nutrient in optimal homeostasis of intestinal mucosal barrier and vitamin D deficiency is related to more severe clinical features of IBS [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Co-Administration of Soy Isoflavones and Vitamin D in Management of Irritable Bowel Disease

Jalili

Hekmatdoost

Vahedi³

et al. 2016

PLoS ONE

View full text Add to dashboard Cite

Background and AimsThe substantial characteristics of Irritable Bowel Syndrome (IBS) are associated with estrogens in women. Both soy isoflavones and vitamin D can modulate estrogen receptors in the colonic smooth muscles. The aim of this study was to investigate the effects of soy isoflavones, vitamin D and their probable interactions in women with IBS.MethodsIn a factorial blinded randomized clinical trial, 100 women with IBS (age:18-75yr, were randomly assigned in 4 arms to receive either placebo of vitamin D and placebo of soy isoflavones (P+P), or placebo of vitamin D and soy isoflavones (P+S), or vitamin D and placebo of soy isoflavones (D+P), or vitamin D and soy isoflavones (D+S) for 6 weeks. Dosage of soy isoflavone was 2 capsules of 20 mg soy isoflavones per day, and dosage of vitamin D was one pearl of 50’000 IU biweekly. The clinical outcomes were IBS symptoms severity scores (IBS-SSS), disease- specific quality of life (IBS-QOL) and total score (IBS-TS) that evaluated at weeks 0, 6, and 10, and compared to each other.ResultsIBS-TS improved significantly in both S+P and D+P groups (p- value = 0.004, 0.015). The interaction effect of soy isoflavones and vitamin D on IBS-TS was significant (p<0.05). The interaction effect of soy isoflavones with vitamin D and the main effect of vitamin D on IBS-SSS were not statistically significant, whereas IBS-SSS decreased significantly in S+P and D+P groups (p-value = 0.001, 0.047 respectively).ConclusionOur results indicate that co-administration of soy isoflavones with vitamin D did not improve the IBS- SSS and IBS- QOL; however, it improved the IBS-TS.Trial RegistrationClinical Trials.gov NCT02026518

show abstract

“…Vitamin D deficiency was significantly associated with depression, a condition not uncommon in patients with IBS [Fond et al 2014; Hoang et al 2011]. Although the role of vitamin D in the pathogenesis of IBS remains to be elucidated, vitamin D supplementation may improve symptoms of IBS, as well as anxiety and depression [Karaahmet et al 2013; Sprake et al 2012]. However, data to support this intriguing hypothesis are sparse and limited to case reports [Sprake et al 2012].…”

Section: Pathophysiology Of Ibsmentioning

confidence: 99%