Letter to the editor: vaccination against upper respiratory infections is a matter of survival in alcoholic liver disease

Itzel, Timo; Falconer, Thomas; Daza, Jimmy; Roig, Ana; Park, Jimyung; Cheong, Jae Youn; Park, Rae Woong; Wiest, Isabella; Ebert, Matthias; Hripcsak, George; Teufel, Andreas

doi:10.1136/gutjnl-2022-327086

Cited by 2 publications

(2 citation statements)

References 8 publications

(13 reference statements)

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“…Broad screening approaches and the detailed analysis of the resulting Big Data in healthcare could further improve prevention in hepatology. As an example, we recently demonstrated that influenza vaccination in patients with alcoholic liver cirrhosis may lead to a significant improvement in survival using the large public electronic health record collection of the international OHDSI (Observational Health Data Sciences and Informatics) consortium [95]. However, we found surprisingly few data available on vaccinations other than hepatitis A and B.…”

Section: Further Improving Prevention In Hepatology-awareness Risk St...mentioning

confidence: 99%

Prevention in Hepatology

Muñoz-Restrepo,

Navas,

Daza

et al. 2024

JPM

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The prevention of liver disease has improved significantly in the last few decades, to the point that it can now be considered a true success story. The wide variety of interventions, including comprehensive vaccination strategies, novel medications, lifestyle changes, and even preventive surgeries, have reduced the morbidity and mortality of chronic liver diseases. However, the prevalence of chronic liver diseases is increasing worldwide. Currently, fatty liver disease alone is estimated to be present in as much as 30% of the adult population. Furthermore, there is a trend towards increasing incidences of chronic hepatitis B, and a global lack of success in efforts to eliminate chronic hepatitis C. Thus, improving and efficiently rolling out existing and successful prevention strategies for chronic liver diseases will play an essential role in healthcare throughout the upcoming decades. In this review, we summarize the current options and concepts for preventing chronic liver diseases, highlight their limitations, and provide an outlook on probable future developments to improve awareness, integrated care, and the analysis of big data.

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Section: Further Improving Prevention In Hepatology-awareness Risk St...mentioning

confidence: 99%

Prevention in Hepatology

Muñoz-Restrepo,

Navas,

Daza

et al. 2024

JPM

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“…Combinational therapies [ 1,2 ] are increasingly becoming a trend in clinic due to the improvement of the therapeutic effect and reduction of patient medication costs. Salt formation between two ionizable drugs, as one of the common strategies for combination medication, could enhance the therapeutic effect of the drugs, allow for combination of two drugs in a single preparation with lowering the frequency of drug administration, [ 3,4 ] and modulate their physicochemical properties such as stability, solubility and bioavailability etc.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Improvements of Physicochemical Properties and Anti‐Microbial Activity of Berberine via Forming Salt with Gallic Acid

Chen,

Yang,

Ren

et al. 2024

Cryst. Res. Technol.

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Implementing combination medication through crystal engineering technology receives increasing attention from researchers due to improvements in the clinical treatment effects as well as the physicochemical properties of the drug. Berberine (BER) is commonly used to treat gastroenteritis and bacterial diarrhea, with the problems of poor solubility and low oral bioavailability. Recently, it is found that gallic acid (GA) also has anti‐inflammatory and anti‐bacterial activities. Therefore, if the above‐mentioned two ingredients can be combined, it is possible to enhance the therapeutic effects and physicochemical properties of BER. Inspired by this, 8‐hydroxy‐7,8‐dihydroberberine (8H‐HBER) in this study is employed to react with gallic acid to yield BER gallate dihydrate (2BER‐2GA‐2 W). Furthermore, dissolution experiments demonstrate that the maximum apparent solubility (MAS) of 2BER‐2GA‐2 W in dilute hydrochloric acid solution medium (pH 1.2) has increased by 7 times compared to the commercial form of BER, because of avoiding the common‐ion effect. Moreover, 2BER‐2GA‐2 W has also obviously enhanced stability relative to the commercial form of BER. In addition, 2BER‐2GA‐2 W has a better inhibitory effect on Staphylococcus aureus (S. aureus) relative to the commercial form of BER. Hence, 2BER‐2GA‐2 W will be a promising solid‐state form of BER for its further development.

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Letter to the editor: vaccination against upper respiratory infections is a matter of survival in alcoholic liver disease

Cited by 2 publications

References 8 publications

Prevention in Hepatology

Prevention in Hepatology

Simultaneous Improvements of Physicochemical Properties and Anti‐Microbial Activity of Berberine via Forming Salt with Gallic Acid

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