Letter to the Editor

Gs, Alarcón; Tm, Beasley; Jm, Roseman; McGwin, Gerald; Bj, Fessler; Hm, Bastian; Vilá, LM; Tan, Fang; Jd, Reveille

doi:10.1191/0961203305lu2184xx

Cited by 41 publications

(10 citation statements)

References 14 publications

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“…We could not demonstrate any effect of ethnicity on the outcome of renal function. Other large cohorts and registries 34 – 36 have reported disappointing results. However, whether genetic or environmental factors or a combination of the two are responsible has yet to be determined.…”

Section: Discussionmentioning

confidence: 98%

Characterization of Patients With Lupus Nephritis Included in a Large Cohort From the Spanish Society of Rheumatology Registry of Patients With Systemic Lupus Erythematosus (RELESSER)

et al. 2016

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Section: Discussionmentioning

confidence: 98%

Characterization of Patients With Lupus Nephritis Included in a Large Cohort From the Spanish Society of Rheumatology Registry of Patients With Systemic Lupus Erythematosus (RELESSER)

et al. 2016

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“…[6][7][8][9][10][11] Fewer studies have examined sociodemographic disparities among children with SLE. The Lupus in Minorities: Nature Versus Nurture cohort consists of African American, white, Texan Hispanic, and Puerto Rican Hispanic subjects.…”

mentioning

confidence: 99%

Outcomes in Hospitalized Pediatric Patients With Systemic Lupus Erythematosus

Son¹,

Johnson

Hersh

et al. 2014

Pediatrics

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OBJECTIVE: Disparities in outcomes among adults with systemic lupus erythematosus (SLE) have been documented. We investigated associations between sociodemographic factors and volume of annual inpatient hospital admissions with hospitalization characteristics and poor outcomes among patients with childhood-onset SLE. METHODS: By using the Pediatric Health Information System, we analyzed admissions for patients aged 3 to <18 years at index admission with ≥1 International Classification of Diseases, Ninth Revision code for SLE from January 2006 to September 2011. Summary statistics and univariable analyses were used to examine demographic characteristics of hospital admissions, readmissions, and lengths of stay. We used multivariable logistic regression analyses, controlling for patient gender, age, race, ethnicity, insurance type, hospital volume, US census region, and severity of illness, to examine risk factors for poor outcomes. RESULTS: A total of 10 724 admissions occurred among 2775 patients over the study period. Hispanic patients had longer lengths of stay, more readmissions, and higher in-hospital mortality. In multivariable analysis, African American race was significantly associated with ICU admission. African American race and Hispanic ethnicity were associated with end-stage renal disease and death. Volume of patients with SLE per hospital and hospital location were not significantly associated with outcomes. CONCLUSIONS: In this cohort of hospitalized children with SLE, race and ethnicity were associated with outcomes. Further studies are needed to elucidate the relationship between sociodemographic factors and poor outcomes in patients with childhood-onset SLE.

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“…16 Specifically, the African component predominates in Puerto Ricans with SLE (45%) as determined by admixture studies. 17 Although Puerto Ricans with SLE have a lower frequency of renal involvement, it is possible that renal disease is more severe in those affected, and thus, require a more aggressive immunosuppressive approach. 9 …”

Section: Discussionmentioning

confidence: 99%