Letter to the Editor

Aldè, Mirko; Ambrosetti, Umberto

doi:10.1111/jpc.16412

Cited by 1 publication

(2 citation statements)

References 4 publications

(7 reference statements)

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“…As a matter of fact, this cCMV screening method is feasible and acceptable to parents, providing the opportunity to start the treatment with oral valganciclovir within the first month of life [ 52 , 53 ]. However, performing cCMV neonatal screening only in babies who fail UNHS would not identify asymptomatic CMV-infected children who will develop late-onset HL [ 54 ]. A large study by Fowler et al has shown that 43% of infants with CMV-related SNHL in the neonatal period and cCMV infants who are at risk of late-onset SNHL were not identified by UNHS [ 55 ].…”

Section: Current Controversies In Preventive Diagnostic and Therapeut...mentioning

confidence: 99%

“…Therefore, new strategies to identify all children with cCMV who remain at risk of late-onset and progressive HL are of paramount importance. In this context, it may be beneficial to extend targeted cCMV screening to children who pass UNHS but are at increased risk of cCMV infection, such as those born SGA or with microencephaly [ 54 ]. Indeed, an expanded targeted early cCMV testing program has been shown to improve detection rates of symptomatic cCMV cases, and should be considered as a valid alternative approach to hearing-targeted CMV testing [ 56 ].…”

Section: Current Controversies In Preventive Diagnostic and Therapeut...mentioning

confidence: 99%

See 1 more Smart Citation

Congenital Cytomegalovirus and Hearing Loss: The State of the Art

Aldè

Binda

Prímache

et al. 2023

JCM

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In developed countries, congenital cytomegalovirus (cCMV) infection is the most common congenital viral infection, representing the leading non-genetic cause of sensorineural hearing loss (HL). Diagnosis of cCMV infection can be performed by detection of CMV DNA in urine or saliva within 2–3 weeks after birth, or later in dried blood samples on the Guthrie card. Currently, there are many controversies regarding the preventive, diagnostic, and therapeutic approaches to cCMV infection. HL secondary to cCMV is highly variable in onset, side, degree, audiometric configuration, and threshold changes over time. Therefore, it is of paramount importance to perform a long and thorough audiological follow-up in children with cCMV infection to ensure early identification and prompt treatment of progressive and/or late-onset HL. Early cochlear implantation appears to be a valid solution not only for children with bilateral profound HL, but also for those with single-sided deafness, improving localization ability and understanding speech in noisy environments. Moreover, the decision to apply a unilateral cochlear implant in children with cCMV is strengthened by the non-negligible possibility of hearing deterioration of the contralateral ear over time.

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