Letter to the Editor Regarding “Cisternostomy in Traumatic Brain Injury: Time for the World to Listen. Cerebrospinal Fluid Release: Possibly the Missing Link in TBI”

Abdulla, Ebtesam; Ravindra, Joseph; Rahman, Sabrina; Rahman, Moshiur

doi:10.1016/j.wneu.2022.03.054

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…In addition, Kumar et al [7] reported in their study on 40 patients a higher 30-day mortality rate for the cisternostomy + DC group (66.6%) compared to the DC alone group (32.2%), with a mean GCS at discharge that was better in the cisternostomy + DC group (11.7 ± 2.9) compared to the DC alone group (10.5 ± 3.7). Abdulla et al [36] drew attention to the fact that complications linked with cisternostomy in TBI are not well documented, as cisternostomy in aneurysm surgery has caused iatrogenic vascular damage perforation, due to poor technique [37,38]. However, cisternostomy seems to decrease the number of days of ventilator support and the length of ICU stay and avoids the need for second surgery in the form of cranioplasty and its associated morbidity [33].…”

Section: Discussionmentioning

confidence: 99%

The Role of Cisternostomy in the Management of Severe Traumatic Brain Injury: A Triple-Center Study

Encarnación Ramirez,

Baez,

Marszal Mangbel’ Mikorska

et al. 2023

Surgeries

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Background: Traumatic brain injury (TBI) is a critical public health problem worldwide, constituting a major cause of mortality and morbidity for people of all ages, but especially in the younger population. Decompressive craniectomy (DC) and cisternostomy are surgical procedures commonly used in the management of severe TBI, but their effectiveness in improving outcomes remains controversial. Methods: We conducted a prospective longitudinal study on patients who underwent surgical treatment for severe TBI between 2021 and 2022. The extended Glasgow outcome scale (GOS-E) was used to assess clinical outcome at 2 weeks, 3 months, and 6 months after surgery. Results: The study included 30 patients (21 men and 9 women) who met the inclusion criteria. Among them, 24 patients (80%) underwent DC combined with cisternostomy, while 6 patients (20%) underwent cisternostomy alone. The initial Glasgow Coma Scale (GCS) score at admission ranged from 4 to 8 points, with an average score of 5.9. The overall mortality and overall morbidity was 13.3% and 20%, respectively. The mortality rate was 12.5% and 16.7% in the DC + cisternostomy group and in the cisternostomy alone group, respectively. No statistically significant difference was seen between the two groups in terms of mortality, morbidity and favorable outcome at 2 weeks, 3 months and 6 months. Conclusions: Our preliminary multi-center study shows a good clinical outcome in patients who underwent DC + cisternostomy or cisternostomy alone in both early and long-term follow-up. Larger multi-center randomized trials are needed to establish the effectiveness of cisternostomy in the management of TBI.

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Section: Discussionmentioning

confidence: 99%

The Role of Cisternostomy in the Management of Severe Traumatic Brain Injury: A Triple-Center Study

Encarnación Ramirez,

Baez,

Marszal Mangbel’ Mikorska

et al. 2023

Surgeries

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“…Moreover, exogenous MIF supplementation can cause nerve cell death in TBI rats, leading to neurological impairment, which might exacerbate the degree of neurological dysfunction. Overall, serum MBP concentration reflects the degree of blood-brain barrier damage and may thus serve as an indicator of the degree of craniocerebral injury ( Abdulla et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Retrospective study on the correlation between serum MIF level and the condition and prognosis of patients with traumatic head injury

Liu,

2023

PeerJ

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Objective This study aimed to investigate the correlation between serum levels of macrophage migration inhibitory factor (MIF) and the condition and prognosis of patients with traumatic brain injury (TBI). Methods A retrospective study design was used, and the clinical data of 131 TBI patients from February 2019 to January 2022 were analyzed. Patients were divided into mild (13–15 points), moderate (9–12 points), or severe (3–8 points) groups according to their Glasgow Coma Scale (GCS) score after admission. The serum levels of BDNF, MIF, and MBP in the three groups were compared, and their correlation with the severity of TBI was analyzed. Patients were then separated into a good prognosis group (4–5 points) and a poor prognosis group (≤3 points) based on their Glasgow Prognostic Score (GOS) after 6 months of follow-up. The predictive power of serum indexes and combined detection on prognosis was analyzed. Results Patients were classified into a mild group (n = 63), moderate group (n = 47), and severe group (n = 21) based on their GCS, with a significant difference noted in serum levels of MIF, MBP, and BDNF among patients with different degrees of severity (all P < 0.001). The MIF, MBP, and BDNF levels were lower in the mild group compared to the moderate (all P < 0.001) and severe group (all P < 0.001). Additionally, the MIF and BDNF levels in the moderate group were lower compared to the severe group (P = 0.011, P = 0.002). Patients with mild severity had lower serum MIF, MBP, and BDNF levels than those with other degrees, and these indexes were positively correlated with the severity of TBI (all P < 0.001, r = 0.62, r = 0.48, r = 0.58). Based on the GOS, patients were divided into a good prognosis group (n = 107) and a poor prognosis group (n = 24), with the levels of MIF, MBP, and BDNF in the good prognosis group being significantly lower than those in the poor prognosis group (P < 0.001, P = 0.007, P = 0.003). The area under the curve (AUC) of MIF was higher than that of MBP and BDNF in predicting the prognosis of TBI patients; however, the statistical differences were not significant (MIF vs. MBP, P = 0.239; MIF vs. BDNF, P = 0.211; BDNF vs. MBP, P = 0.899). The center line has a large displacement, CT annular cisterna compression, increased white blood cell count, MBP and BDNF were risk factors for prognosis in TBI patients (P = 0.005, P = 0.001, P = 0.005, P = 0.033, P = 0.044). Conclusion The serum levels of MIF, MBP, and BDNF in TBI patients were positively correlated with the severity of the disease, and MBP, BDNF levels had predictive value in determining patient prognosis.

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Letter to the Editor Regarding “Cisternostomy in Traumatic Brain Injury: Time for the World to Listen. Cerebrospinal Fluid Release: Possibly the Missing Link in TBI”

Cited by 2 publications

References 11 publications

The Role of Cisternostomy in the Management of Severe Traumatic Brain Injury: A Triple-Center Study

The Role of Cisternostomy in the Management of Severe Traumatic Brain Injury: A Triple-Center Study

Retrospective study on the correlation between serum MIF level and the condition and prognosis of patients with traumatic head injury

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