2011
DOI: 10.1038/modpathol.2011.94
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Letter to the editor regarding ‘Roh MH, Lassin Y, Miron A et al. High-grade fimbrial-ovarian carcinomas are unified by p53, PTEN and PAX2 expression‘

Abstract: Letter to the editor regarding 'Roh MH, Lassin Y, Miron A et al. High-grade fimbrial-ovarian carcinomas are unified by p53, PTEN and PAX2 expression'

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Cited by 6 publications
(4 citation statements)
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“…Reclassification of EC to HGSC is an expected result, which has been shown previously in a morphological review of a large population-based series in Canada (21). The differential diagnosis of HGSC and EC, particularly in higher grade cases, is still a matter of controversy among pathologists (22). But many now advocate that the vast majority of cases that show high-grade nuclear atypia regardless of architectural features should be diagnosed as HGSC (2, 3639).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Reclassification of EC to HGSC is an expected result, which has been shown previously in a morphological review of a large population-based series in Canada (21). The differential diagnosis of HGSC and EC, particularly in higher grade cases, is still a matter of controversy among pathologists (22). But many now advocate that the vast majority of cases that show high-grade nuclear atypia regardless of architectural features should be diagnosed as HGSC (2, 3639).…”
Section: Discussionmentioning
confidence: 99%
“…However, without specific training, which better reflects current pathology practice, the inter-observer agreement is only moderate with Cohen’s κ varying between 0.54 and 0.67 (20). A major diagnostic shift has occurred in recent years affecting the classification of carcinomas with glandular architecture and high-grade nuclear features that were formerly classified as high-grade EC to now be diagnosed as HGSC (Figure S1) (21, 22). This shift is justified by the fact that those carcinomas are molecularly indistinguishable from the morphologically typical HGSC (23).…”
Section: Introductionmentioning
confidence: 99%
“…Using a cutoff of greater than 70% expression and 0% expression (representing a nonsense mutation of p53), an abnormal pattern of p53 expression will be seen in approximately 80% to 90% cases of serous carcinoma. 12,[16][17][18] An important caveat to overreliance on this single antibody is that an abnormal pattern of p53 expression can be seen in a few endometrioid adenocarcinomas (~10%), predominantly in FIGO 3 cases. 19,20 Of note, in cases with ambiguous morphology, where a definitive histologic subtype cannot be established, aberrant p53 expression has been correlated with adverse clinical outcomes.…”
Section: A Useful Panel Of Markers In Ambiguous Casesmentioning
confidence: 99%
“…29 The concept of splitting vs lumping high-grade Müllerian carcinomas has been contentious in the past, with the argument that the clinical outcome and treatment was the same regardless of the subclassification. 30 Since that time, Soslow et al 23 validated the significance of different histologic patterns by describing variant morphologies (SET) in tumors with BRCA germline mutations that are associated with a better prognosis and a better response to chemotherapy. 3,4,[12][13][14][15][16][17][18][19] We previously reported on a separate cohort of high-grade serous carcinomas, showing an association between BRCA-positivity and variant histology (SET-like), younger age, a lower frequency of serous tubal intraepithelial carcinoma, and trends toward improved survival.…”
Section: Discussionmentioning
confidence: 99%