Letter to the editor—Mortality rate of acute kidney injury in SARS, MERS, and COVID-19 infection: a systematic review and meta-analysis

Swai, Joel

doi:10.1186/s13054-020-03239-0

Cited by 5 publications

(5 citation statements)

References 5 publications

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“…SARS-CoV-2 belongs to the viral family Coronaviridae in which three new coronaviruses have emerged from animal reservoirs in the past two decades causing serious illness and death: SARS-CoV, Middle East respiratory syndrome coronavirus (MERS-CoV), and now SARS-CoV-2 (2). In addition to respiratory distress, patients with COVID-19 exhibit systemic symptoms that involve the kidneys, similarly to previous SARS-CoV and MERS-CoV outbreaks (3)(4)(5). Chronic kidney disease and its causes such as hypertension and diabetes are noted risk factors for developing severe COVID-19 disease, and COVID-19 patients frequently develop acute kidney injury (AKI) (3,6).…”

Section: Introductionmentioning

confidence: 74%

“…In addition to respiratory distress, patients with COVID-19 exhibit systemic symptoms that involve the kidneys, similarly to previous SARS-CoV and MERS-CoV outbreaks (3)(4)(5). Chronic kidney disease and its causes such as hypertension and diabetes are noted risk factors for developing severe COVID-19 disease, and COVID-19 patients frequently develop acute kidney injury (AKI) (3,6). Angiotensin-converting enzyme 2 (ACE2) is the primary entry receptor for SARS-CoV-2 in many experimental models and is strongly expressed in the proximal tubular epithelial cells of the kidney, implicating the kidney as a target for SARS-CoV-2 infection (7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 74%

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Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations

Helms¹,

Marchianò²,

Stanaway³

et al. 2021

JCI Insight

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Kidneys are critical target organs of COVID-19, but susceptibility and responses to infection remain poorly understood. Here, we combine SARS-CoV-2 variants with genome-edited kidney organoids and clinical data to investigate tropism, mechanism, and therapeutics. SARS-CoV-2 specifically infects organoid proximal tubules among diverse cell types. Infections produce replicating virus, apoptosis, and disrupted cell morphology, features of which are revealed in the context of polycystic kidney disease. Cross-validation of gene expression patterns in organoids reflects proteomic signatures of COVID-19 in the urine of critically ill patients indicating interferon pathway upregulation. SARS-CoV-2 viral variants alpha, beta, gamma, kappa, and delta exhibit comparable levels of infection in organoids. Infection is ameliorated in ACE2–/– organoids and blocked via treatment with de novo–designed spike binder peptides. Collectively, these studies clarify the impact of kidney infection in COVID-19 as reflected in organoids and clinical populations, enabling assessment of viral fitness and emerging therapies.

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Section: Introductionmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 74%

Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations

Helms¹,

Marchianò²,

Stanaway³

et al. 2021

JCI Insight

View full text Add to dashboard Cite

show abstract

“…Article 4 of the Pre-plan stipulates: ‘In response to possible epidemics in marine operations, formulate marine atypical pneumonia prevention and treatment measures and emergency medical treatment procedures for fishing vessels and crews’ ( MoARA-PRC, 2003 ). The COVID-19 pandemic spreads faster than the SARS and is more contagious ( Swai, 2020 ). After the outbreak of the COVID-19, it has become more challenging for fishing vessels and seamen to operate at sea, but their protective equipment and medical services have improved compared with those during the SARS epidemic.…”

Section: Analysis Of the Current Legal Safeguard Measures And Policy Recommendationsmentioning

confidence: 99%

The impact of the COVID-19 on China's fisheries sector and its countermeasures

Chang

Zhang

Khan

2022

Ocean & Coastal Management

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“…The OR for COVID-19 patients with AKI-associated mortality was reported to be as high as 23.95%. In some 710 COVID-19 patients who reported to the hospital, prevalence of elevated markers of renal function such as serum creatinine and blood urea nitrogen (BUN) was 15.5% and 14.1% respectively, with 26.9% of these patients coming in with microscopic hematuria and 44% having proteinuria although the incidence of AKI in these patients was reported as 3.2% [ 23 ]. According to this and other supporting data, AKI is likely associated with worse prognosis in COVID-19 patients and increases their mortality rates [ 24 , 25 ].…”

Section: Impact Of Covid-19 On Kidney Conditionsmentioning

confidence: 99%

Renal consequences of the novel coronavirus disease 2019 (COVID-19) and hydrogen sulfide as a potential therapy

et al. 2022

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The novel coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is a global pandemic which is primarily considered a respiratory illness. However, emerging reports show that the virus exhibits both pulmonary and extra-pulmonary manifestations in humans, with the kidney as a major extra-pulmonary target due to its abundant expression of angiotensin-converting enzyme 2 and transmembrane protease serine 2, which facilitate entry of the virus into cells. Acute kidney injury has become prevalent in COVID-19 patients without prior any history of kidney dysfunction. In addition, the virus also worsens kidney conditions and increases mortality of COVID-19 patients with pre-existing chronic kidney disease, renal cancer, diabetic nephropathy, end-stage kidney disease as well as dialysis and kidney transplant patients. In the search for antiviral agents for the treatment of COVID-19, hydrogen sulfide (H 2 S), the third established member of gasotransmitter family, is emerging as a potential candidate, possessing important therapeutic properties including antiviral, anti-inflammatory, anti-thrombotic and antioxidant properties. A recent clinical study revealed higher serum H 2 S levels in survivors of COVID-19 pneumonia with reduced interleukin-6 levels compared to fatal cases. In this review, we summarize the global impact of COVID-19 on kidney conditions and discuss the emerging role of H 2 S as a potential COVID-19 therapy.

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Letter to the editor—Mortality rate of acute kidney injury in SARS, MERS, and COVID-19 infection: a systematic review and meta-analysis

Cited by 5 publications

References 5 publications

Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations

Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations

The impact of the COVID-19 on China's fisheries sector and its countermeasures

Renal consequences of the novel coronavirus disease 2019 (COVID-19) and hydrogen sulfide as a potential therapy

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