Letter to the Editor: Influence of rTMS on smoking in patients with schizophrenia

Kamp, Daniel; Engelke, Christina; Wobrock, Thomas; Kunze, Birgit; Wölwer, Wolfgang; Winterer, Georg; Schmidt-Kraepelin, Christian; Gäebel, Wolfgang; Langguth, Berthold; Landgrebe, Michael; Eichhammer, Peter; Frank, Elmar; Hajak, Göran; Ohmann, Christian; Verde, Pablo Emilio; Rietschel, Marcella; Raees, A. G.; Honer, William G.; Malchow, Berend; Schneider‐Axmann, Thomas; Falkai, Peter; Hasan, Alkomiet; Cordes, Joachim

doi:10.1016/j.schres.2017.05.036

Cited by 10 publications

(8 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Overall, overnight abstinence produced a significant increase in tobacco craving and withdrawal, and impaired verbal memory and visuo-spatial working memory in both diagnostic groups; these effects were reversed with smoking reinstatement consistent with our previous findings (Sacco et al, 2005; Wing et al, 2012a). However, active rTMS did not modify this pattern of results, similar to a recently published report (Kamp et al, 2017). Moreover, active versus sham rTMS was not associated with significant adverse events (data not shown).…”

Section: Dear Editorsupporting

confidence: 92%

Effects of short-term, high-frequency repetitive transcranial magnetic stimulation to bilateral dorsolateral prefrontal cortex on smoking behavior and cognition in patients with schizophrenia and non-psychiatric controls

Kozak

Sharif-Razi

Morozova

et al. 2018

Schizophrenia Research

View full text Add to dashboard Cite

show abstract

Section: Dear Editorsupporting

confidence: 92%

Effects of short-term, high-frequency repetitive transcranial magnetic stimulation to bilateral dorsolateral prefrontal cortex on smoking behavior and cognition in patients with schizophrenia and non-psychiatric controls

Kozak

Sharif-Razi

Morozova

et al. 2018

Schizophrenia Research

View full text Add to dashboard Cite

show abstract

“…Finally, researchers have used heterogeneous treatment parameters that make the results difficult to pool and to overall compare the efficacy of rTMS on nicotine dependence [58,59]. Previous studies in smokers with comorbid schizophrenia showed that multiple sessions of rTMS did not affect the cue craving and cigarette consumption [60,61]. Nevertheless, most of the previous studies showed the evidence of treatment efficacy of rTMS for smoking cessation.…”

Section: Discussionmentioning

confidence: 99%

Two weeks of image-guided left dorsolateral prefrontal cortex repetitive transcranial magnetic stimulation improves smoking cessation: A double-blind, sham-controlled, randomized clinical trial

Hartwell

Henderson

et al. 2020

Brain Stimulation

View full text Add to dashboard Cite

Background: Previous studies have found that repetitive transcranial magnetic stimulation (rTMS) to the left dorsal lateral prefrontal cortex (LDLPFC) transiently reduces smoking craving, decreases cigarette consumption, and increases abstinence rates. Objective: We investigated whether 10 daily MRI-guided rTMS sessions over two weeks to the LDLPFC paired with craving cues could reduce cigarette consumption and induce smoking cessation. Methods: We enrolled 42 treatment-seeking nicotine-dependent smokers (!10 cigarettes per day) in a randomized, double-blind, sham-controlled trial. Participants received 10 daily sessions over 2 weeks of either active or sham MRI-guided rTMS (10Hz, 3000 pulses each session) to the LDLPFC concurrently with video smoking cues. The primary outcome was a reduction in biochemically confirmed cigarette consumption with a secondary outcome of abstinence on the target quit date. We also recorded cueinduced craving and withdrawal symptoms. Results: Compared to sham (n ¼ 17), participants receiving active rTMS (n ¼ 21) smoked significantly fewer cigarettes per day during the 2-week treatment (mean [SD], 13.73[9.18] vs. 11.06[9.29], P < .005) and at 1-month follow-up (12.78[9.53] vs. 7.93[7.24], P < .001). Active rTMS participants were also more likely to quit by their target quit rate (23.81%vs. 0%, OR 11.67, 90% CL, 0.96e141.32, x 2 ¼ 4.66, P ¼ .031). Furthermore, rTMS significantly reduced mean craving throughout the treatments and at follow-up (29.93[13.12] vs. 25.01[14.45], P < .001). Interestingly across the active treatment sample, more lateral coil location was associated with more success in quitting (À43.43[0.40] vs. À41.79[2.24], P < .013). Conclusions: Daily MRI-guided rTMS to the LDLPFC for 10 days reduces cigarette consumption and cued craving for up to one month and also increases the likelihood of smoking cessation. Trial registration: ClinicalTrials.gov identifier: NCT02401672.

show abstract

“…We identified 5 studies using rTMS for nicotine dependence in schizophrenia (34)(35)(36)(37)(38). Wing et al conducted a 10-week randomized, double-blind, sham-controlled trial of rTMS for smokers with schizophrenia to reduce craving during a smoking cessation attempt (34).…”

Section: Nibs For Nicotine Dependence In Schizophrenia Has Mixed Resultsmentioning

confidence: 99%

“…The studies were from multiple countries, including Canada ( n = 2) ( 34 , 38 ), China ( n = 1) ( 36 ), the Czech Republic ( n = 1) ( 35 ), Germany ( n = 1) ( 37 ), and the United States ( n = 1) ( 39 ).…”

Section: Introductionmentioning

confidence: 99%

“…In a secondary analysis of the rTMS for the Treatment of Negative Symptoms in Schizophrenia (RESIS) trial, Kamp et al analyzed the effect of high frequency rTMS on daily cigarette consumption in a sample of individuals with schizophrenia with predominantly negative symptoms ( 37 ). Participants ( n = 67) were randomized to active or sham rTMS.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Noninvasive Brain Stimulation for Nicotine Dependence in Schizophrenia: A Mini Review

et al. 2022

View full text Add to dashboard Cite

Individuals with schizophrenia are 10 times more likely to have a tobacco use disorder than the general population. Up to 80% of those with schizophrenia smoke tobacco regularly, a prevalence three-times that of the general population. Despite the striking prevalence of tobacco use in schizophrenia, current treatments are not tailored to the pathophysiology of this population. There is growing support for use of noninvasive brain stimulation (NIBS) to treat substance use disorders (SUDs), particularly for tobacco use in neurotypical smokers. NIBS interventions targeting the dorsolateral prefrontal cortex have been effective for nicotine dependence in control populations—so much so that transcranial magnetic stimulation is now FDA-approved for smoking cessation. However, this has not borne out in the studies using this approach in schizophrenia. We performed a literature search to identify articles using NIBS for the treatment of nicotine dependence in people with schizophrenia, which identified six studies. These studies yielded mixed results. Is it possible that nicotine has a unique effect in schizophrenia that is different than its effect in neurotypical smokers? Individuals with schizophrenia may receive additional benefit from nicotine's pro-cognitive effects than control populations and may use nicotine to improve brain network abnormalities from their illness. Therefore, clinical trials of NIBS interventions should test a schizophrenia-specific target for smoking cessation. We propose a generalized approach whereby schizophrenia-specific brain circuitry related to SUDs is be identified and then targeted with NIBS interventions.

show abstract

Letter to the Editor: Influence of rTMS on smoking in patients with schizophrenia

Cited by 10 publications

References 8 publications

Effects of short-term, high-frequency repetitive transcranial magnetic stimulation to bilateral dorsolateral prefrontal cortex on smoking behavior and cognition in patients with schizophrenia and non-psychiatric controls

Effects of short-term, high-frequency repetitive transcranial magnetic stimulation to bilateral dorsolateral prefrontal cortex on smoking behavior and cognition in patients with schizophrenia and non-psychiatric controls

Two weeks of image-guided left dorsolateral prefrontal cortex repetitive transcranial magnetic stimulation improves smoking cessation: A double-blind, sham-controlled, randomized clinical trial

Noninvasive Brain Stimulation for Nicotine Dependence in Schizophrenia: A Mini Review

Contact Info

Product

Resources

About