Letter to the editor

Pj, Klein; Ra, Newman; Müller, P; Uhlenbruck, G.; He, Schaefer; Kj, Lennartz; Fischer, R.

doi:10.1007/bf01487824

Search citation statements

Order By: Relevance

Paper Sections

Select...

Introduction1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1988

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They can selectively bind sugar residues of glycoproteins and have been used as probes for investigating dif ferences between normal and neoplastic cell mem branes. In recent years a lectin isolated from peanuts (Arachis hvpogaea), the peanut aglutinin (PNA), has been shown to bind to breast cancer cells [1][2][3]. The reaction of this lectin with the mammary epithelium was associated with differentiation [4] and hormone dependence [5].…”

Section: Introductionmentioning

confidence: 99%

Peanut Agglutinin Inhibits Proliferation of Cultured Breast Cancer Cells

Marth

Daxenbichler²

1988

Oncology

View full text Add to dashboard Cite

Cultured breast cancer cells express on their surface glycoproteins which are recognized by the peanut lectin (PNA). The proliferation of these cells (ZR-75.1 and 734-B) was inhibited by PNA. A mammary carcinoma cell line (BT-20) which does not react with PNA was not affected by this lectin. The combination of PNA with either retinoic acid or 4-hydroxy-tamoxifen led to an additive amplification of the antiproliferative activity. Also interferon-γ showed in combination with PNA an improved growth-inhibitory action.

show abstract

Section: Introductionmentioning

confidence: 99%