Letter to the Editor

BACKGROUND AND AIMS: Considerable difficulties persist amongst pathologists in agreeing on the presence and severity of gastric atrophy. An international group of pathologists pursued the following aims: (i) to generate an acceptable definition and a simple reproducible classification of gastric atrophy; and (ii) to develop guidelines for the recognition of atrophy useful for increasing agreement among observers.\ud \ud METHODS: After redefining atrophy as the 'loss of appropriate glands' and examining histological samples from different gastric compartments, three categories were identified: (i) negative; (ii) indefinite; (iii) atrophy, with and without intestinalization. Atrophy was graded on a three-level scale. Interobserver reproducibility of the classification was tested by kappa statistics (general and weighted) in a series of 48 cases.\ud \ud RESULTS: The medians of the general agreement and weighted kappa values were 0.78 and 0.73, respectively. The weighted kappa coefficients, obtained by cross-tabulating the evaluation of each pathologist against all others, were, with only one exception, > 0.4 (moderate to excellent agreement).\ud \ud CONCLUSIONS: By using the definition of atrophy as the loss of appropriate glands and distinguishing the two main morphological entities of metaplastic and non-metaplastic types, a high level of agreement was achieved by a group of gastrointestinal pathologists trained in different cultural contexts

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Urease-Based Mucosal Immunization againstHelicobacter heilmanniiInfection Induces Corpus Atrophy in Mice

Dieterich

Bouzourène

Corthésy–Theulaz

1999

Infect Immun

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Letter to the Editor

Cited by 4 publications

References 3 publications

Precancerous Lesions: Atrophic Gastritis, Intestinal Metaplasia, Natural Course of Chronic Gastritis and Associated Risk Factors

Precancerous Lesions: Atrophic Gastritis, Intestinal Metaplasia, Natural Course of Chronic Gastritis and Associated Risk Factors

Gastric mucosal atrophy: interobserver consistency using new criteria for classification and grading

Urease-Based Mucosal Immunization againstHelicobacter heilmanniiInfection Induces Corpus Atrophy in Mice

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