Letter to the Editor

Falk, Gregory L.; Gibson, Simon C.; Page, PA Le

doi:10.1007/s11605-012-2091-3

Cited by 2 publications

(4 citation statements)

References 3 publications

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“…The most pronounced differences in administration of adjuvant chemotherapy between laparoscopy and open surgery were found in the extended MVR subgroup (71% vs 44%) and in the emergency setting (60% vs 39%), suggesting that minimizing surgical trauma is only becoming clinically relevant in such high-risk patients. Two series including substantial numbers of T4b cases also reported higher rates of adjuvant chemotherapy after laparoscopic as compared to open surgery (63% vs 37%, p =0.047 and 71% vs 57%, p =0.513) 13,16…”

Section: Discussionmentioning

confidence: 98%

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<p>Laparoscopic surgery facilitates administration of adjuvant chemotherapy in locally advanced colon cancer: propensity score analyses</p>

Wasmann¹,

Klaver²,

Bilt³

et al. 2019

CMAR

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Purpose The aim of this study was to evaluate the impact of a laparoscopic approach on long-term oncological outcomes in curative intent surgery for pT4 colon cancer, in both overall and stratified subgroups with distinct clinical entities. Patients and methods Patients with a pT4N0-2M0 colon cancer from four centers between 2000 and 2014 were included. Laparoscopic and open approaches were compared according to the intention-to-treat principle. Propensity scores were used to adjust for baseline differences between the groups in three manners: i) as a linear predictor in a Cox regression model, ii) to create a 1:1 matched cohort, and iii) to stratify patients into four groups with an increasing chance of receiving laparoscopy. Results In total, 424 patients were included. After 1:1 matching, a laparoscopic approach correlated with higher rates of radical resection, lower morbidity, and a higher percentage of patients receiving adjuvant chemotherapy. This translated into better 5-year disease-free survival (52% vs 40%, HR 0.70; 95% CI 0.50–0.96) and 5-year overall survival (68% vs 57%, HR 0.66; 95% CI 0.43–0.99). These results were confirmed in the other two propensity score analyses. In the multivariable models, adjuvant chemotherapy remained independently associated with better survival, whereas surgical approach lost significance. Conclusions In locally advanced colon cancer, an intentional laparoscopic approach in experienced hands seems to decrease morbidity and to increase the proportion of patients receiving adjuvant chemotherapy. Receiving adjuvant chemotherapy was independently associated with improved survival.

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Section: Discussionmentioning

confidence: 98%

“…In this multicenter series, a 100% R0 resection rate in 40 patients requiring MVR was found. Four studies assessed outcomes after laparoscopic resection of pT4b colon cancer in relatively small cohorts of 15–23 patients 9,11,13,20,29. R0 resection rates were 83%, 93%, 96%, and 100%, respectively.…”

Section: Discussionmentioning

confidence: 99%

<p>Laparoscopic surgery facilitates administration of adjuvant chemotherapy in locally advanced colon cancer: propensity score analyses</p>

Wasmann¹,

Klaver²,

Bilt³

et al. 2019

CMAR

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“…As shown in Table 2, the quality of the three studies varied considerably, the data on the risk of bias are presented in the supplementary material. 20,21 Serum anti-rotavirus IgA seroconversion rates Seroconversion was defined as a serum concentration of anti-rotavirus IgA antibodies < 20U/mL in 6-week subjects who were seropositive (≥ 20U/mL) after vaccination. Because the study heterogeneity analysis showed p = 0.441 and I 2 = 0.0%, the fixed-effects model was applied.…”

Section: Resultsmentioning

confidence: 99%

“…The guidelines from the Cochrane Handbook and Jadad quality scores were used to assess the quality of each of the included studies. 20,21 Data was analyzed using STATA version 12.0. To evaluate the standard error (SE) a calculation was performed using the formula: SE = (95% CI, upper limit-lower limit)/ 3.92.…”

Section: Risk Of Bias and Data Analysismentioning

confidence: 99%

Immunogenicity of different dosing schedules of the human live attenuate rotavirus vaccine (RV1) in infants and children: a meta-analysis

Dai

Bai

Jian

et al. 2018

Human Vaccines & Immunotherapeutics

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Rotavirus immunization strategies have become part of a comprehensive global public health program to control rotavirus-associated gastroenteritis, particularly in infants and children in developing countries. Several studies have reported the efficacy of different rotavirus vaccine dosing schedules, but with mixed findings. Therefore a systematic review of the published literature on rotavirus vaccination dosing schedules using the live attenuated RV1 rotavirus vaccine in infants and children, including randomized controlled clinical trials (RCTs), published between January 1998 to January 2018 was conducted, with meta-analysis of the published data. The literature search was performed using six databases. The initial review identified 495 publications, of which three satisfied the selection eligibility criteria. The three studies that assessed RV1 rotavirus vaccine immunogenicity compared a two-dose vaccination schedule with a three-dose vaccination schedule. The use of a three-dose vaccination schedule did not show a statistically significant seroconversion rate when compared with a two-dose vaccination schedule (OR = 0.87; 95% CI,: 0.65-1.17;, p-= 0.298). Analysis of included studies with one-month follow-up time showed that the three-dose vaccination schedule did not result in have significantly increased geometric mean concentrations (GMCs) compared with the two-dose vaccination schedule (p = 0.311). Rotavirus immunogenicity did not increase significantly with the three-dose schedule at 6, 10 and 14 weeks with the two-dose schedule at 10 and 14 weeks. These findings indicate that further controlled studies should be undertaken to support the optimum immunization schedules for rotavirus in terms of clinical effectiveness and cost-effectiveness, particularly for infants and children in developing countries.

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Letter to the Editor

Cited by 2 publications

References 3 publications

<p>Laparoscopic surgery facilitates administration of adjuvant chemotherapy in locally advanced colon cancer: propensity score analyses</p>

<p>Laparoscopic surgery facilitates administration of adjuvant chemotherapy in locally advanced colon cancer: propensity score analyses</p>

Immunogenicity of different dosing schedules of the human live attenuate rotavirus vaccine (RV1) in infants and children: a meta-analysis

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