Letter: Steatorrhoea complicating therapy with mefenamic acid.

Chadwick, R. G.; Hossenbocus, A; Colin‐Jones, D G

doi:10.1136/bmj.1.6006.397-b

Cited by 19 publications

(5 citation statements)

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“…Furthermore, some patients in our literature review could switch to taking other NSAIDs, for example, ibuprofen, without disease recurrence (Table S1). [ 10 , 14 ]…”

Section: Discussionmentioning

confidence: 99%

“…Some patients were confirmed resolution of the lesions by endoscopy or tissue biopsy. [ 10 – 12 , 14 , 15 , 18 , 20 – 22 ] Some patients had recurrence of symptoms when mefenamic acid was re-challenged. [ 14 , 15 , 20 , 21 ] These evidences suggest that mefenamic acid was the cause of diarrhea in the patients in this study.…”

Section: Discussionmentioning

confidence: 99%

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Severe enteropathy with villous atrophy in prolonged mefenamic acid users – a currently under-recognized in previously well-recognized complication

Kaosombatwattana¹,

Limsrivilai²,

Pongpaibul

et al. 2017

Medicine

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“…Furthermore, some patients in our literature review could switch to taking other NSAIDs, for example, ibuprofen, without disease recurrence (Table S1). [ 10 , 14 ]…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Severe enteropathy with villous atrophy in prolonged mefenamic acid users – a currently under-recognized in previously well-recognized complication

Kaosombatwattana¹,

Limsrivilai²,

Pongpaibul

et al. 2017

Medicine

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“…The overall incidence of inflammatory bowel disease (excluding Crohn's disease) in the general population is 8/100,000/year. The 4 cases reported are presenting from the population on NSAID medications (6,725). This represents an inci dence of 40/100,000/year in this group indi cating a roughly fivefold increase in the risk of developing inflammatory bowel disease in this population.…”

Section: Discussionmentioning

confidence: 99%

“…The association be tween NSAID medications and colonic dis ease has been well described [1][2][3][4][5]. Diar rhoea, steatorrhoea [6] and colitis have all been reported particularly with mefenamic acid (Ponstan) or indomethacin [7], Pre vious studies have essentially been case re ports and no systematic analysis of the fre quency of NSAID-related colonic inflamma tion has been published. The present study has been designed to assess the frequency of this problem in a gastroenterology clinic at a nonteaching District General Hospital.…”

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confidence: 99%

Colonic Inflammation and Nonsteroidal Anti-Inflammatory Drug Administration

Tanner

Raghunath²

1988

Digestion

101

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Over an 18-month period at a single clinic, 43 new cases of colonic inflammation have been diagnosed (19 proctitis only). Crohn’s colitis has been excluded from this analysis. In all these subjects a careful drug history has been taken in a prospective manner and in 4 of these 43 patients colonic inflammation appeared to be directly related to nonsteroidal anti-inflammatory drug (NSAID) administration (mefenamic acid, 2; piroxicam, 2). In all 4 patients there was a time interval (mean 3 months) between initiation of treatment with NSAID and presentation with diarrhoea and weight loss. Pathological findings were minor and biochemical changes insignificant, in contrast to the protracted troublesome symptoms. Resolution of symptoms was very rapid on discontinuation of NSAID medication but 2 patients experienced immediate return of symptoms following inadvertent rechallenge. Approximately 10% of newly diagnosed colitis may be related to NSAID administration. Subjects taking NSAID medications appear to be five times more likely to develop colonic inflammation than the general population.

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“…Small bowel abnormalities are well recognised as a side‐effect of treatment with non‐steroidal antiinflammatory drugs, 1 and steatorrhoea has been observed to complicate treatment with mefenamic acid. Small bowel biopsy appearances may be normal, 2 or demonstrate a spectrum of histological change from simple inflammatory cell infiltration 3 to reversible villous abnormalities of varying severity 4–6 …”

mentioning

confidence: 99%