Letter: risk factor and mortality of peptic ulcer disease

Xy, Zhang; Hy, Mo; Huang, Yao

doi:10.1111/apt.13708

Cited by 5 publications

(3 citation statements)

References 6 publications

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“…The most common causes of PUD are Helicobacter pylori infection, as well as the use of anti-inflammatory drugs, which additionally aggravate the disease leading to complications, such as gastrointestinal haemorrhage or perforation. Since the use of nonsteroidal anti-inflammatory drugs and corticosteroids is becoming more widespread, peptic ulcer complications have emerged as a substantial healthcare problem [ 1 , 2 ]. In addition, infection by H. pylori causes chronic inflammation, which has been suggested to develop to gastric cancer—the third leading cause of cancer-related deaths, according to the World Health Organization (WHO) [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Spray-Dried Potato Juice as a Potential Functional Food Component with Gastrointestinal Protective Effects

et al. 2018

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Background: Peptic ulcer disease, including its complications and functional dyspepsia, are prevalent gastrointestinal diseases, etiopathogenesis of which is associated with mucosal inflammation. Research into new therapeutics capable of preventing or curing gastrointestinal mucosal damage has been steadily developing over past decades. This study was undertaken to evaluate whether a spray-dried preparation of potato juice is applicable for treating and preventing gastrointestinal mucosal damage. Methods: We assessed potential protective effects of spray-dried potato juice (SDPJ) against gut inflammation in the co-culture Caco-2/RAW264.7 system, as well as a gastroprotective activity in a rat model of gastric ulceration. Results: The obtained results indicated that SDPJ down-regulates lipopolysaccharide (LPS)-induced mRNA expression and protein production of proinflammatory cytokines IL-6 and TNF-α in the co-culture model. Moreover, SDPJ provided dose-dependent protection against LPS-induced disruption of intestinal barrier integrity. In rats, five-day pretreatment with SDPJ in doses of 200 mg/kg and 500 mg/kg suppressed HCl/ethanol-induced TNF-α expression in gastric mucosa by 52% and 35%, respectively. In addition, the pretreatment with the lower dose of SDPJ reduced the incidence of ulcers (by 34%) expressed as ulcer index. Conclusion: The spray-dried potato juice appears to be an attractive candidate for ameliorating inflammation-related diseases of the gastrointestinal tract.

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Section: Introductionmentioning

confidence: 99%

Spray-Dried Potato Juice as a Potential Functional Food Component with Gastrointestinal Protective Effects

et al. 2018

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“…Describing the serious complications of PUD leading to death in more detail, as suggested in the letter from Zhang et al, 1 and analysing clinical decisions made in individual patients' care would have given us even more detailed data on the characteristics of PUD patients. Unfortunately, in our national death register-based study, individual patient data was not accessible.…”

mentioning

confidence: 99%

“…1 In addition, no synthesis of data was performed. All the data (r, r 2 , or P) of the results was based on one of the included studies.…”

mentioning

confidence: 99%

Letter: risk factor and mortality of peptic ulcer disease – authors′ reply

Malmi

Kautiainen

Virta

et al. 2016

Aliment Pharmacol Ther

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Diagnosis ofHelicobacter pyloriUsing Invasive and Noninvasive Approaches

Abadi

2018

Journal of Pathogens

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Helicobacter pylori (H. pylori) as gram-negative and spiral microorganism is responsible for colonization in the gastric microniche for more than 50% of world population. Recent studies have shown a critical role of H. pylori in the development of peptic ulcers, gastric mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric cancer. Over the past decade, there has been a sharp interest to use noninvasive tests in diagnosis of the H. pylori infection. During the years after discovery by Marshall and Warren, it has been frequently declared that the rapid urease test (RUT) is one of the cheapest and rapid diagnostic approaches used in detecting the infection. Although the specificity and sensitivity are durable for this test, clinical experiences had shown that the ideal results are only achieved only if we take biopsies from both corpus and antrum at the same time. Given the diagnosis of the H. pylori in clinical samples, gastroenterologists are facing a long list of various molecular and nonmolecular tests. We need more in-depth researches and investigations to correctly generalize rapid and accurate molecular tests determining both bacterial identity and antibiotic resistance profile.

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Letter: risk factor and mortality of peptic ulcer disease

Cited by 5 publications

References 6 publications

Spray-Dried Potato Juice as a Potential Functional Food Component with Gastrointestinal Protective Effects

Spray-Dried Potato Juice as a Potential Functional Food Component with Gastrointestinal Protective Effects

Letter: risk factor and mortality of peptic ulcer disease – authors′ reply

Diagnosis ofHelicobacter pyloriUsing Invasive and Noninvasive Approaches

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