Letter regarding “Interference of doxycycline pretreatment in a model of abdominal aortic aneurysms”

Bi, Yonghua; Zhong, Hongshan; Xu, Ke; Wu, Gang; Han, Xinwei

doi:10.1016/j.carpath.2015.01.003

Cardiovascular Pathology

2015

DOI: 10.1016/j.carpath.2015.01.003

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Letter regarding “Interference of doxycycline pretreatment in a model of abdominal aortic aneurysms”

Yonghua Bi¹,

Hongshan Zhong

Ke Xu

et al.

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Cited by 2 publications

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“…

We would like to thank you and your group for your interest in our work and for the opportunity to clarify some aspects of this novel experimental model of abdominal aortic aneurysms (AAAs) [1]. It is a relatively recent research area for our group, and several different aspects are under investigation in our laboratory.

Some years ago, we developed this experimental model of AAA in Wistar rats almost spontaneously.

…”

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confidence: 99%

Response to the “Letter regarding Interference of doxycycline pretreatment in a model of abdominal aortic aneurysms”

Mata

Fernandes

Tefé‐Silva

et al. 2015

Cardiovascular Pathology

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“…

Some years ago, we developed this experimental model of AAA in Wistar rats almost spontaneously.

…”

mentioning

confidence: 99%

Response to the “Letter regarding Interference of doxycycline pretreatment in a model of abdominal aortic aneurysms”

Mata

Fernandes

Tefé‐Silva

et al. 2015

Cardiovascular Pathology

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A new mixed model of periodontitis‐induced preeclampsia: A pilot study

Mata

Nobre

Silva

et al. 2021

J of Periodontal Research

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Objectives/Background: Recent studies have shown that periodontal disease is strongly related to gestational complications such as preeclampsia (PE). PE is responsible for 42% of maternal deaths worldwide and kills approximately 76 000 women a year. In addition, children born under PE conditions are at increased risk of hospitalization due to metabolic disorders, epilepsy, and other complications. Numerous reviews and clinical studies on PE have been published, but the mechanisms underlying the relationship between periodontal disease and PE and the way periodontopathogens alter vascular response in pregnant women remain unclear.Methods: This study aims to verify whether periodontal disease induces PE by using the association of two periodontitis (PD) models: ligature and oral Porphyromonas gingivalis (P. gingivalis) W83 inoculation in Wistar rats. At gestational day 5, the ligature was placed on each mandibular first molar, which was followed by daily oral P. gingivalis inoculation for 15 days. At gestational day 19, urine was collected, and invasive arterial pressure was measured. The animals were euthanized, and plasma and tissues were collected.Results: After 15 days of the association of ligature and P. gingivalis inoculation, the animals presented the characteristic symptoms of PE: altered blood pressure, proteinuria, and change in litter size (number of pups) and pup weight when compared to the control group (p < .005). The PE animals also presented greater bone porosity, trabecular separation, and reduced bone volume in the hemimandibles, as well as altered inflammatory response. The level of cytokine IL-6 was higher in the PE group than in the control group (p < .005). Conclusion:The association of two PD models effectively induced PE. To our knowledge, this is the first study on the oral use of P. gingivalis for PE induction. Our results support the importance of PD as a possible cause for PE development, opening an | 727 MATA eT Al.

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Letter regarding “Interference of doxycycline pretreatment in a model of abdominal aortic aneurysms”

Cited by 2 publications

References 4 publications

Response to the “Letter regarding Interference of doxycycline pretreatment in a model of abdominal aortic aneurysms”

Response to the “Letter regarding Interference of doxycycline pretreatment in a model of abdominal aortic aneurysms”

A new mixed model of periodontitis‐induced preeclampsia: A pilot study

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