Letter Regarding Article by Luo et al, “Adenovirus-Mediated Expression of β-Adrenergic Receptor Kinase C-Terminus Reduces Intimal Hyperplasia and Luminal Stenosis of Arteriovenous Polytetrafluoroethylene Grafts in Pigs”

Rotmans, Joris I.; Stroes, Erik S.G.; Pasterkamp, Gérard

doi:10.1161/circulationaha.105.559930

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Endovascular Approaches1

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2013

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“…Significant inhibition of neointimal hyperplasia at the veingraft anastomosis at 4 weeks occurred compared with mocktransfected AVG. However, a 100% stenosis rate was observed in the mock-transfected AVG that is much higher than stenosis rates reported by others in that swine model (63,64).…”

Section: Endovascular Approachescontrasting

confidence: 63%

Novel Therapies for Hemodialysis Vascular Access Dysfunction

Terry

Dember

2013

Clinical Journal of the American Society of Nephrology

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SummaryHemodialysis vascular access dysfunction is a major source of morbidity for patients with ESRD. Development of effective approaches to prevent and treat vascular access failure requires an understanding of the underlying mechanisms, suitable models for preclinical testing, systems for targeted delivery of interventions to maximize efficacy and minimize toxicity, and rigorous clinical trials that use appropriate outcome measures. This article reviews the substantial progress and ongoing challenges in developing novel treatments for arteriovenous vascular access failure and focuses on localized rather than systemic interventions.

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Section: Endovascular Approachescontrasting

confidence: 63%