Letter: proton pump inhibitors, GERD and oesophageal adenocarcinoma

Letter: proton pump inhibitors, GERD and oesophageal adenocarcinoma – authors' reply

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SIRS, As pointed out in the letter by Dr Rosch, the effect of continuous proton pump inhibitor (PPI) therapy in patients with Barrett's oesophagus might at best be symptomatic treatment, whereasof more concernit could potentially promote dysplastic progression and adenocarcinoma rather than prevent it. 1 We initially hypothesised that patients in our Barrett's cohort who were taking their PPI medication regularly (very high adherence) were less likely to develop dysplasia and adenocarcinoma. However, we were surprised to find that the opposite seemed to be the case.

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